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Giant malignant phyllodes tumour of breast.

Krishnamoorthy R, Savasere T, Prabhuswamy VK, Babu R, Shivaswamy S - Case Rep Oncol Med (2014)

Bottom Line: Examination revealed mass in the right breast measuring 36×32 cms with lobulated firm surface and weighing 10 kgs.Postoperatively the patient received chemotherapy and radiotherapy.The patient is on follow-up for a year and has not shown any evidence of metastasis or recurrence.

View Article: PubMed Central - PubMed

Affiliation: Department of General Surgery, Victoria Hospital, Bangalore Medical College and Research Institute, Bangalore, India.

ABSTRACT
The term phyllodes tumour includes lesions ranging from completely benign tumours to malignant sarcomas. Clinically phyllodes tumours are smooth, rounded, and usually painless multinodular lesions indistinguishable from fibroadenomas. Percentage of phyllodes tumour classified as malignant ranges from 23% to 50%. We report a case of second largest phyllodes tumour in a 35-year-old lady who presented with swelling of right breast since 6 months, initially small in size, that progressed gradually to present size. Examination revealed mass in the right breast measuring 36×32 cms with lobulated firm surface and weighing 10 kgs. Fine needle aspiration cytology was reported as borderline phyllodes; however core biopsy examination showed biphasic neoplasm with malignant stromal component. Simple mastectomy was done and specimen was sent for histopathological examination which confirmed the core biopsy report. Postoperatively the patient received chemotherapy and radiotherapy. The patient is on follow-up for a year and has not shown any evidence of metastasis or recurrence.

No MeSH data available.


Related in: MedlinePlus

Cut surface of the specimen.
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fig7: Cut surface of the specimen.

Mentions: Under cervical epidural anaesthesia, right simple mastectomy (Figures 3 and 4) was performed and incision closed primarily (Figure 5). Macroscopy revealed a lobulated tumour of size 33(L) × 32(B) × 22(D) cms, weighing 10 kgs (Figure 6). Cut section revealed multiple grey white lobulated fleshy areas with focal hemorrhagic and necrotic areas (Figure 7). Microscopic examination demonstrated high stromal cellularity and high mitotic rate > 10/10 hpf with moderate pleomorphism and extensive areas of tumour necrosis, confirming the diagnosis of malignant phyllodes tumour (Figure 8). All the resected margins were free of tumour. Based on histopathological examination a diagnosis of malignant phyllodes was made. Proliferation markers like Ki-67 and P53 were in the range of 12-13% and 5–7%, respectively.


Giant malignant phyllodes tumour of breast.

Krishnamoorthy R, Savasere T, Prabhuswamy VK, Babu R, Shivaswamy S - Case Rep Oncol Med (2014)

Cut surface of the specimen.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4273467&req=5

fig7: Cut surface of the specimen.
Mentions: Under cervical epidural anaesthesia, right simple mastectomy (Figures 3 and 4) was performed and incision closed primarily (Figure 5). Macroscopy revealed a lobulated tumour of size 33(L) × 32(B) × 22(D) cms, weighing 10 kgs (Figure 6). Cut section revealed multiple grey white lobulated fleshy areas with focal hemorrhagic and necrotic areas (Figure 7). Microscopic examination demonstrated high stromal cellularity and high mitotic rate > 10/10 hpf with moderate pleomorphism and extensive areas of tumour necrosis, confirming the diagnosis of malignant phyllodes tumour (Figure 8). All the resected margins were free of tumour. Based on histopathological examination a diagnosis of malignant phyllodes was made. Proliferation markers like Ki-67 and P53 were in the range of 12-13% and 5–7%, respectively.

Bottom Line: Examination revealed mass in the right breast measuring 36×32 cms with lobulated firm surface and weighing 10 kgs.Postoperatively the patient received chemotherapy and radiotherapy.The patient is on follow-up for a year and has not shown any evidence of metastasis or recurrence.

View Article: PubMed Central - PubMed

Affiliation: Department of General Surgery, Victoria Hospital, Bangalore Medical College and Research Institute, Bangalore, India.

ABSTRACT
The term phyllodes tumour includes lesions ranging from completely benign tumours to malignant sarcomas. Clinically phyllodes tumours are smooth, rounded, and usually painless multinodular lesions indistinguishable from fibroadenomas. Percentage of phyllodes tumour classified as malignant ranges from 23% to 50%. We report a case of second largest phyllodes tumour in a 35-year-old lady who presented with swelling of right breast since 6 months, initially small in size, that progressed gradually to present size. Examination revealed mass in the right breast measuring 36×32 cms with lobulated firm surface and weighing 10 kgs. Fine needle aspiration cytology was reported as borderline phyllodes; however core biopsy examination showed biphasic neoplasm with malignant stromal component. Simple mastectomy was done and specimen was sent for histopathological examination which confirmed the core biopsy report. Postoperatively the patient received chemotherapy and radiotherapy. The patient is on follow-up for a year and has not shown any evidence of metastasis or recurrence.

No MeSH data available.


Related in: MedlinePlus