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Non-alcoholic fatty liver disease associated with gallstones in females rather than males: a longitudinal cohort study in Chinese urban population.

Liu J, Lin H, Zhang C, Wang L, Wu S, Zhang D, Tang F, Xue F, Liu Y - BMC Gastroenterol (2014)

Bottom Line: The GEE analyses confirmed and clarified the association between NAFLD and gallstones (relative risk (RR) = 1.2381, 95% confidence interval (CI) = 1.003-1.528, P = 0.047) after adjusting for other potential confounding factors, especially in females (RR = 1.707, 95% CI = 1.245-2.341, P = 0.001).Moreover, this association is more strongly apparent in females than in males.Further cohort studies must be conducted to confirm this association in the general population.

View Article: PubMed Central - PubMed

Affiliation: Department of Epidemiology and Biostatistics, School of Public Health, Shandong University, PO Box 100, Jinan, 250012, China. liujia250189@163.com.

ABSTRACT

Background: Whether non-alcoholic fatty liver disease (NAFLD) is a risk factor for gallstones remains uncertain. Few longitudinal or cohort studies have been used to identify this relationship. The aim of this study was to confirm the association between NAFLD and gallstones in a longitudinal cohort of urban dwellers in China.

Methods: To elucidate the association between NAFLD and gallstones, we fitted a generalized estimating equation (GEE) model in a large-scale longitudinal cohort over 6 years, which included 11,200 participants with at least three regular health check-ups.

Results: A total of 498 cases of gallstones occurred during the 6-year follow-up, which resulted in a total incidence density of 12.73 per 1000 person-years (498/39, 135.5 person-years). The GEE analyses confirmed and clarified the association between NAFLD and gallstones (relative risk (RR) = 1.2381, 95% confidence interval (CI) = 1.003-1.528, P = 0.047) after adjusting for other potential confounding factors, especially in females (RR = 1.707, 95% CI = 1.245-2.341, P = 0.001).

Conclusions: NAFLD is associated with gallstones in an urban Chinese population from the middle to upper socioeconomic strata. Moreover, this association is more strongly apparent in females than in males. Further cohort studies must be conducted to confirm this association in the general population.

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The longitudinal cohort study sample for analysis of association between non-alcoholic fatty liver disease and gallstones.
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Fig1: The longitudinal cohort study sample for analysis of association between non-alcoholic fatty liver disease and gallstones.

Mentions: A large-scale longitudinal cohort study was set up in 2005, comprising urban Han Chinese from middle to upper socioeconomic strata who attended a routine health check-up at Centers for Health Management of Shandong Provincial Qianfoshan Hospital and Shandong Provincial Hospital. The geographic area served by the two hospitals covered the city of Jinan, the capital of Shandong province with a population of approximately 7 million. The health check-up database contained relatively rich and educated persons in Jinan, representing the middle to upper class population of Shandong province. Based on the large-scale longitudinal cohort, a sub-cohort was selected from those free of gallstones at baseline. A total of 11,200 participants with at least three health checks in the 6-year follow-up were included in the sub-cohort between 2005 and 2010 (Figure 1).Figure 1


Non-alcoholic fatty liver disease associated with gallstones in females rather than males: a longitudinal cohort study in Chinese urban population.

Liu J, Lin H, Zhang C, Wang L, Wu S, Zhang D, Tang F, Xue F, Liu Y - BMC Gastroenterol (2014)

The longitudinal cohort study sample for analysis of association between non-alcoholic fatty liver disease and gallstones.
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4273434&req=5

Fig1: The longitudinal cohort study sample for analysis of association between non-alcoholic fatty liver disease and gallstones.
Mentions: A large-scale longitudinal cohort study was set up in 2005, comprising urban Han Chinese from middle to upper socioeconomic strata who attended a routine health check-up at Centers for Health Management of Shandong Provincial Qianfoshan Hospital and Shandong Provincial Hospital. The geographic area served by the two hospitals covered the city of Jinan, the capital of Shandong province with a population of approximately 7 million. The health check-up database contained relatively rich and educated persons in Jinan, representing the middle to upper class population of Shandong province. Based on the large-scale longitudinal cohort, a sub-cohort was selected from those free of gallstones at baseline. A total of 11,200 participants with at least three health checks in the 6-year follow-up were included in the sub-cohort between 2005 and 2010 (Figure 1).Figure 1

Bottom Line: The GEE analyses confirmed and clarified the association between NAFLD and gallstones (relative risk (RR) = 1.2381, 95% confidence interval (CI) = 1.003-1.528, P = 0.047) after adjusting for other potential confounding factors, especially in females (RR = 1.707, 95% CI = 1.245-2.341, P = 0.001).Moreover, this association is more strongly apparent in females than in males.Further cohort studies must be conducted to confirm this association in the general population.

View Article: PubMed Central - PubMed

Affiliation: Department of Epidemiology and Biostatistics, School of Public Health, Shandong University, PO Box 100, Jinan, 250012, China. liujia250189@163.com.

ABSTRACT

Background: Whether non-alcoholic fatty liver disease (NAFLD) is a risk factor for gallstones remains uncertain. Few longitudinal or cohort studies have been used to identify this relationship. The aim of this study was to confirm the association between NAFLD and gallstones in a longitudinal cohort of urban dwellers in China.

Methods: To elucidate the association between NAFLD and gallstones, we fitted a generalized estimating equation (GEE) model in a large-scale longitudinal cohort over 6 years, which included 11,200 participants with at least three regular health check-ups.

Results: A total of 498 cases of gallstones occurred during the 6-year follow-up, which resulted in a total incidence density of 12.73 per 1000 person-years (498/39, 135.5 person-years). The GEE analyses confirmed and clarified the association between NAFLD and gallstones (relative risk (RR) = 1.2381, 95% confidence interval (CI) = 1.003-1.528, P = 0.047) after adjusting for other potential confounding factors, especially in females (RR = 1.707, 95% CI = 1.245-2.341, P = 0.001).

Conclusions: NAFLD is associated with gallstones in an urban Chinese population from the middle to upper socioeconomic strata. Moreover, this association is more strongly apparent in females than in males. Further cohort studies must be conducted to confirm this association in the general population.

Show MeSH
Related in: MedlinePlus