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A hereditary disposition for bovine peripheral nerve sheath tumors in Danish Holstein cattle.

Grossi AB, Agerholm JS, Christensen K, Jensen HE, Leifsson PS, Bendixen C, Karlskov-Mortensen P, Fredholm M - Acta Vet. Scand. (2014)

Bottom Line: PNSTs were significantly more common in the Danish Holstein breed than in other breeds with 0.49% of Danish Holsteins slaughtered during an eight-year-period having PNSTs.PNSTs also occurred significantly more frequently in the offspring of some specific Holstein sires.Danish Holsteins are genetically disposed to develop PNSTs but the examined materials are insufficient to allow determination of the mode of inheritance.

View Article: PubMed Central - PubMed

Affiliation: Department of Veterinary Disease Biology, Faculty of Health and Medical Sciences, University of Copenhagen, Ridebanevej 3, 1870, Frederiksberg C, Denmark. abg@minipigs.dk.

ABSTRACT

Background: Peripheral nerve sheath tumors (PNSTs) are frequently found in Danish cattle at slaughter. Bovine PNSTs share several gross and histopathological characteristics with the PNSTs in humans with heritable neurofibromatosis syndromes. The aim of the present study was to investigate a possible hereditary disposition to PNSTs in dairy cattle by statistical analysis performed on data from 567 cattle with PNSTs. Furthermore, a preliminary genome-wide association study (GWAS) was performed on DNA isolated from 28 affected and 28 non-affected Holstein cows to identify loci in the bovine genome involved in the development of PNSTs.

Results: PNSTs were significantly more common in the Danish Holstein breed than in other breeds with 0.49% of Danish Holsteins slaughtered during an eight-year-period having PNSTs. PNSTs also occurred significantly more frequently in the offspring of some specific Holstein sires. Examination of three generation pedigrees showed that these sires were genetically related through a widely used US Holstein sire. The PNSTs included in GWAS were histologically classified as neurofibroma-schwannoma (43%), schwannoma (36%) and neurofibroma (21%) and derived from Holstein cows with multiple PNSTs. A single SNP on chromosome 27 reached genome-wide significance.

Conclusions: Gross and histological characteristics of bovine PNSTs are comparable to PNSTs in humans (schwannomatosis). Danish Holsteins are genetically disposed to develop PNSTs but the examined materials are insufficient to allow determination of the mode of inheritance.

No MeSH data available.


Related in: MedlinePlus

Bovine peripheral nerve sheath tumors. Two tumors (arrows) located in relation to intercostal nerves (not visible). Specimen displaying the internal surface of the thorax. R: rib.
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Fig1: Bovine peripheral nerve sheath tumors. Two tumors (arrows) located in relation to intercostal nerves (not visible). Specimen displaying the internal surface of the thorax. R: rib.

Mentions: The 28 Holstein cows included in the genetic analysis all presented with multiple PNSTs that were confined to the brachial nerve plexus (21), intercostal nerves (21) (FigureĀ 1), mediastinal nerves (16), the heart (9), spinal nerve roots (2), and in lymph nodes (1).Figure 1


A hereditary disposition for bovine peripheral nerve sheath tumors in Danish Holstein cattle.

Grossi AB, Agerholm JS, Christensen K, Jensen HE, Leifsson PS, Bendixen C, Karlskov-Mortensen P, Fredholm M - Acta Vet. Scand. (2014)

Bovine peripheral nerve sheath tumors. Two tumors (arrows) located in relation to intercostal nerves (not visible). Specimen displaying the internal surface of the thorax. R: rib.
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4269924&req=5

Fig1: Bovine peripheral nerve sheath tumors. Two tumors (arrows) located in relation to intercostal nerves (not visible). Specimen displaying the internal surface of the thorax. R: rib.
Mentions: The 28 Holstein cows included in the genetic analysis all presented with multiple PNSTs that were confined to the brachial nerve plexus (21), intercostal nerves (21) (FigureĀ 1), mediastinal nerves (16), the heart (9), spinal nerve roots (2), and in lymph nodes (1).Figure 1

Bottom Line: PNSTs were significantly more common in the Danish Holstein breed than in other breeds with 0.49% of Danish Holsteins slaughtered during an eight-year-period having PNSTs.PNSTs also occurred significantly more frequently in the offspring of some specific Holstein sires.Danish Holsteins are genetically disposed to develop PNSTs but the examined materials are insufficient to allow determination of the mode of inheritance.

View Article: PubMed Central - PubMed

Affiliation: Department of Veterinary Disease Biology, Faculty of Health and Medical Sciences, University of Copenhagen, Ridebanevej 3, 1870, Frederiksberg C, Denmark. abg@minipigs.dk.

ABSTRACT

Background: Peripheral nerve sheath tumors (PNSTs) are frequently found in Danish cattle at slaughter. Bovine PNSTs share several gross and histopathological characteristics with the PNSTs in humans with heritable neurofibromatosis syndromes. The aim of the present study was to investigate a possible hereditary disposition to PNSTs in dairy cattle by statistical analysis performed on data from 567 cattle with PNSTs. Furthermore, a preliminary genome-wide association study (GWAS) was performed on DNA isolated from 28 affected and 28 non-affected Holstein cows to identify loci in the bovine genome involved in the development of PNSTs.

Results: PNSTs were significantly more common in the Danish Holstein breed than in other breeds with 0.49% of Danish Holsteins slaughtered during an eight-year-period having PNSTs. PNSTs also occurred significantly more frequently in the offspring of some specific Holstein sires. Examination of three generation pedigrees showed that these sires were genetically related through a widely used US Holstein sire. The PNSTs included in GWAS were histologically classified as neurofibroma-schwannoma (43%), schwannoma (36%) and neurofibroma (21%) and derived from Holstein cows with multiple PNSTs. A single SNP on chromosome 27 reached genome-wide significance.

Conclusions: Gross and histological characteristics of bovine PNSTs are comparable to PNSTs in humans (schwannomatosis). Danish Holsteins are genetically disposed to develop PNSTs but the examined materials are insufficient to allow determination of the mode of inheritance.

No MeSH data available.


Related in: MedlinePlus