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Effects of acupuncture knife on inflammatory factors and pain in third lumbar vertebrae transverse process syndrome model rats.

Yu JN, Guo CQ, Hu B, Liu NG, Sun HM, Xu H, Wu HX, Guo Y, Liang CX, Chen ZX, Li XH - Evid Based Complement Alternat Med (2014)

Bottom Line: The aim of this paper was to explore the long-term effects and pain relief mechanism of acupuncture knife on third lumbar vertebrae (L3) transverse process syndrome.The tail flick test was used to observe pain threshold.AK pretreatment could alleviate pain through modulating inflammatory response.

View Article: PubMed Central - PubMed

Affiliation: School of Acupuncture and Moxibustion, Beijing University of Chinese Medicine, No. 11 North 3rd Ring East Road, Chaoyang District, Beijing 100029, China.

ABSTRACT
The aim of this paper was to explore the long-term effects and pain relief mechanism of acupuncture knife on third lumbar vertebrae (L3) transverse process syndrome. Forty SD rats were randomized into control, model, electroacupuncture (EA), and acupuncture knife (AK) group. Except control rats, other rats were subjected to an operation to emulate L3 transverse process syndrome. Fourteen days after the operation, EA and AK rats were given electroacupuncture and acupuncture knife treatments, respectively. Fifty-six days after the operation, enzyme-linked immunosorbent assay was used to measure substance P (SP), 5-hydroxytryptamine (5-HT), interleukin-1β (IL-1β), interleukin-10 (IL-10), tumor necrosis factor-α (TNF-α), and transforming growth factor-β (TGF-β) in peripheral blood. The tail flick test was used to observe pain threshold. We found that rats with the simulation operation had significantly higher levels of SP, 5-HT, IL-1, IL-10, TNF-α, and TGF-β, while the AK rats had lower levels. In addition, the pain threshold of AK rats was similar to that of control rats. AK pretreatment could alleviate pain through modulating inflammatory response.

No MeSH data available.


Related in: MedlinePlus

Effects of AK on SP and 5-HT in peripheral blood in the following groups (n = 10 per group): control, model, EA, and AK. Compared with the control group, *P < 0.01, **P < 0.05; compared with the model group, #P < 0.01; compared with the EA group, ▲P < 0.05.
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fig5: Effects of AK on SP and 5-HT in peripheral blood in the following groups (n = 10 per group): control, model, EA, and AK. Compared with the control group, *P < 0.01, **P < 0.05; compared with the model group, #P < 0.01; compared with the EA group, ▲P < 0.05.

Mentions: Fifty-six days after operation, compared with the control group, the model, EA, and AK groups had significantly higher SP levels in the peripheral blood (P < 0.05 or P < 0.01). Compared with the model group, the EA and AK groups had significantly lower SP levels in the peripheral blood (P < 0.01). There was no significant difference in SP among the EA and AK groups (P > 0.05). Compared with the control group, the model, EA, and AK groups had significantly higher 5-HT levels in the peripheral blood (P < 0.01). Compared with the model group, the EA and AK groups had significantly lower 5-HT levels in the peripheral blood (P < 0.01). The 5-HT of the AK group was higher than that of the EA group (P < 0.05; Figure 5).


Effects of acupuncture knife on inflammatory factors and pain in third lumbar vertebrae transverse process syndrome model rats.

Yu JN, Guo CQ, Hu B, Liu NG, Sun HM, Xu H, Wu HX, Guo Y, Liang CX, Chen ZX, Li XH - Evid Based Complement Alternat Med (2014)

Effects of AK on SP and 5-HT in peripheral blood in the following groups (n = 10 per group): control, model, EA, and AK. Compared with the control group, *P < 0.01, **P < 0.05; compared with the model group, #P < 0.01; compared with the EA group, ▲P < 0.05.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4269310&req=5

fig5: Effects of AK on SP and 5-HT in peripheral blood in the following groups (n = 10 per group): control, model, EA, and AK. Compared with the control group, *P < 0.01, **P < 0.05; compared with the model group, #P < 0.01; compared with the EA group, ▲P < 0.05.
Mentions: Fifty-six days after operation, compared with the control group, the model, EA, and AK groups had significantly higher SP levels in the peripheral blood (P < 0.05 or P < 0.01). Compared with the model group, the EA and AK groups had significantly lower SP levels in the peripheral blood (P < 0.01). There was no significant difference in SP among the EA and AK groups (P > 0.05). Compared with the control group, the model, EA, and AK groups had significantly higher 5-HT levels in the peripheral blood (P < 0.01). Compared with the model group, the EA and AK groups had significantly lower 5-HT levels in the peripheral blood (P < 0.01). The 5-HT of the AK group was higher than that of the EA group (P < 0.05; Figure 5).

Bottom Line: The aim of this paper was to explore the long-term effects and pain relief mechanism of acupuncture knife on third lumbar vertebrae (L3) transverse process syndrome.The tail flick test was used to observe pain threshold.AK pretreatment could alleviate pain through modulating inflammatory response.

View Article: PubMed Central - PubMed

Affiliation: School of Acupuncture and Moxibustion, Beijing University of Chinese Medicine, No. 11 North 3rd Ring East Road, Chaoyang District, Beijing 100029, China.

ABSTRACT
The aim of this paper was to explore the long-term effects and pain relief mechanism of acupuncture knife on third lumbar vertebrae (L3) transverse process syndrome. Forty SD rats were randomized into control, model, electroacupuncture (EA), and acupuncture knife (AK) group. Except control rats, other rats were subjected to an operation to emulate L3 transverse process syndrome. Fourteen days after the operation, EA and AK rats were given electroacupuncture and acupuncture knife treatments, respectively. Fifty-six days after the operation, enzyme-linked immunosorbent assay was used to measure substance P (SP), 5-hydroxytryptamine (5-HT), interleukin-1β (IL-1β), interleukin-10 (IL-10), tumor necrosis factor-α (TNF-α), and transforming growth factor-β (TGF-β) in peripheral blood. The tail flick test was used to observe pain threshold. We found that rats with the simulation operation had significantly higher levels of SP, 5-HT, IL-1, IL-10, TNF-α, and TGF-β, while the AK rats had lower levels. In addition, the pain threshold of AK rats was similar to that of control rats. AK pretreatment could alleviate pain through modulating inflammatory response.

No MeSH data available.


Related in: MedlinePlus