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Effects of acupuncture knife on inflammatory factors and pain in third lumbar vertebrae transverse process syndrome model rats.

Yu JN, Guo CQ, Hu B, Liu NG, Sun HM, Xu H, Wu HX, Guo Y, Liang CX, Chen ZX, Li XH - Evid Based Complement Alternat Med (2014)

Bottom Line: The aim of this paper was to explore the long-term effects and pain relief mechanism of acupuncture knife on third lumbar vertebrae (L3) transverse process syndrome.The tail flick test was used to observe pain threshold.AK pretreatment could alleviate pain through modulating inflammatory response.

View Article: PubMed Central - PubMed

Affiliation: School of Acupuncture and Moxibustion, Beijing University of Chinese Medicine, No. 11 North 3rd Ring East Road, Chaoyang District, Beijing 100029, China.

ABSTRACT
The aim of this paper was to explore the long-term effects and pain relief mechanism of acupuncture knife on third lumbar vertebrae (L3) transverse process syndrome. Forty SD rats were randomized into control, model, electroacupuncture (EA), and acupuncture knife (AK) group. Except control rats, other rats were subjected to an operation to emulate L3 transverse process syndrome. Fourteen days after the operation, EA and AK rats were given electroacupuncture and acupuncture knife treatments, respectively. Fifty-six days after the operation, enzyme-linked immunosorbent assay was used to measure substance P (SP), 5-hydroxytryptamine (5-HT), interleukin-1β (IL-1β), interleukin-10 (IL-10), tumor necrosis factor-α (TNF-α), and transforming growth factor-β (TGF-β) in peripheral blood. The tail flick test was used to observe pain threshold. We found that rats with the simulation operation had significantly higher levels of SP, 5-HT, IL-1, IL-10, TNF-α, and TGF-β, while the AK rats had lower levels. In addition, the pain threshold of AK rats was similar to that of control rats. AK pretreatment could alleviate pain through modulating inflammatory response.

No MeSH data available.


Related in: MedlinePlus

Effects of AK on IL-1β and TNF-α in peripheral blood in the following groups (n = 10 per group): control, model, EA, and AK. Compared with the control group, *P < 0.01; compared with the model group, #P < 0.01, ##P < 0.05.
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fig3: Effects of AK on IL-1β and TNF-α in peripheral blood in the following groups (n = 10 per group): control, model, EA, and AK. Compared with the control group, *P < 0.01; compared with the model group, #P < 0.01, ##P < 0.05.

Mentions: Fifty-six days after operation, IL-1β and TNF-α levels in the model group were significantly higher than that in the other three groups (P < 0.05 or P < 0.01). Compared with the control group, there was no significant difference in IL-1β and TNF-α in the EA and AK groups (P > 0.05). There was no significant difference in IL-1β and TNF-α between the EA and AK groups (P > 0.05) (Figure 3). The IL-10 level in the model group was significantly higher than that in the other three groups (P < 0.01). Compared with the control group, there was no significant difference in IL-10 in the EA and AK groups (P > 0.05). There were no significant differences in IL-10 among the EA and AK groups (P > 0.05). Compared with the control group, TGF-β in the model, EA, and AK groups were significantly higher (P < 0.01 or P < 0.05). Compared with the model group, TGF-β in the EA and AK groups were significantly lower (P < 0.01). There was no difference between the EA and AK groups (P > 0.05; Figure 4).


Effects of acupuncture knife on inflammatory factors and pain in third lumbar vertebrae transverse process syndrome model rats.

Yu JN, Guo CQ, Hu B, Liu NG, Sun HM, Xu H, Wu HX, Guo Y, Liang CX, Chen ZX, Li XH - Evid Based Complement Alternat Med (2014)

Effects of AK on IL-1β and TNF-α in peripheral blood in the following groups (n = 10 per group): control, model, EA, and AK. Compared with the control group, *P < 0.01; compared with the model group, #P < 0.01, ##P < 0.05.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4269310&req=5

fig3: Effects of AK on IL-1β and TNF-α in peripheral blood in the following groups (n = 10 per group): control, model, EA, and AK. Compared with the control group, *P < 0.01; compared with the model group, #P < 0.01, ##P < 0.05.
Mentions: Fifty-six days after operation, IL-1β and TNF-α levels in the model group were significantly higher than that in the other three groups (P < 0.05 or P < 0.01). Compared with the control group, there was no significant difference in IL-1β and TNF-α in the EA and AK groups (P > 0.05). There was no significant difference in IL-1β and TNF-α between the EA and AK groups (P > 0.05) (Figure 3). The IL-10 level in the model group was significantly higher than that in the other three groups (P < 0.01). Compared with the control group, there was no significant difference in IL-10 in the EA and AK groups (P > 0.05). There were no significant differences in IL-10 among the EA and AK groups (P > 0.05). Compared with the control group, TGF-β in the model, EA, and AK groups were significantly higher (P < 0.01 or P < 0.05). Compared with the model group, TGF-β in the EA and AK groups were significantly lower (P < 0.01). There was no difference between the EA and AK groups (P > 0.05; Figure 4).

Bottom Line: The aim of this paper was to explore the long-term effects and pain relief mechanism of acupuncture knife on third lumbar vertebrae (L3) transverse process syndrome.The tail flick test was used to observe pain threshold.AK pretreatment could alleviate pain through modulating inflammatory response.

View Article: PubMed Central - PubMed

Affiliation: School of Acupuncture and Moxibustion, Beijing University of Chinese Medicine, No. 11 North 3rd Ring East Road, Chaoyang District, Beijing 100029, China.

ABSTRACT
The aim of this paper was to explore the long-term effects and pain relief mechanism of acupuncture knife on third lumbar vertebrae (L3) transverse process syndrome. Forty SD rats were randomized into control, model, electroacupuncture (EA), and acupuncture knife (AK) group. Except control rats, other rats were subjected to an operation to emulate L3 transverse process syndrome. Fourteen days after the operation, EA and AK rats were given electroacupuncture and acupuncture knife treatments, respectively. Fifty-six days after the operation, enzyme-linked immunosorbent assay was used to measure substance P (SP), 5-hydroxytryptamine (5-HT), interleukin-1β (IL-1β), interleukin-10 (IL-10), tumor necrosis factor-α (TNF-α), and transforming growth factor-β (TGF-β) in peripheral blood. The tail flick test was used to observe pain threshold. We found that rats with the simulation operation had significantly higher levels of SP, 5-HT, IL-1, IL-10, TNF-α, and TGF-β, while the AK rats had lower levels. In addition, the pain threshold of AK rats was similar to that of control rats. AK pretreatment could alleviate pain through modulating inflammatory response.

No MeSH data available.


Related in: MedlinePlus