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Effects of acupuncture knife on inflammatory factors and pain in third lumbar vertebrae transverse process syndrome model rats.

Yu JN, Guo CQ, Hu B, Liu NG, Sun HM, Xu H, Wu HX, Guo Y, Liang CX, Chen ZX, Li XH - Evid Based Complement Alternat Med (2014)

Bottom Line: The aim of this paper was to explore the long-term effects and pain relief mechanism of acupuncture knife on third lumbar vertebrae (L3) transverse process syndrome.The tail flick test was used to observe pain threshold.AK pretreatment could alleviate pain through modulating inflammatory response.

View Article: PubMed Central - PubMed

Affiliation: School of Acupuncture and Moxibustion, Beijing University of Chinese Medicine, No. 11 North 3rd Ring East Road, Chaoyang District, Beijing 100029, China.

ABSTRACT
The aim of this paper was to explore the long-term effects and pain relief mechanism of acupuncture knife on third lumbar vertebrae (L3) transverse process syndrome. Forty SD rats were randomized into control, model, electroacupuncture (EA), and acupuncture knife (AK) group. Except control rats, other rats were subjected to an operation to emulate L3 transverse process syndrome. Fourteen days after the operation, EA and AK rats were given electroacupuncture and acupuncture knife treatments, respectively. Fifty-six days after the operation, enzyme-linked immunosorbent assay was used to measure substance P (SP), 5-hydroxytryptamine (5-HT), interleukin-1β (IL-1β), interleukin-10 (IL-10), tumor necrosis factor-α (TNF-α), and transforming growth factor-β (TGF-β) in peripheral blood. The tail flick test was used to observe pain threshold. We found that rats with the simulation operation had significantly higher levels of SP, 5-HT, IL-1, IL-10, TNF-α, and TGF-β, while the AK rats had lower levels. In addition, the pain threshold of AK rats was similar to that of control rats. AK pretreatment could alleviate pain through modulating inflammatory response.

No MeSH data available.


Related in: MedlinePlus

Effects of pain threshold on tail flick test in each group (n = 10 per group): control, model, EA, and AK. Compared with the control group, *P < 0.01, **P < 0.05. Compared with the model group, #P < 0.05.
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fig2: Effects of pain threshold on tail flick test in each group (n = 10 per group): control, model, EA, and AK. Compared with the control group, *P < 0.01, **P < 0.05. Compared with the model group, #P < 0.05.

Mentions: The results of the pain threshold of tail flick test are shown in Figure 2. The pain threshold of the control group at different time points did not show obvious changes. The other three groups showed lower pain threshold from the second day after the operation. At 14 days, the day before performing treatment, compared with the control group, the model, EA, and AK group had a lower pain threshold (P < 0.01 or P < 0.05) and there were no statistical differences between the model, EA, and AK groups. After treatments, the pain threshold of the EA and AK group rose. From days 17 to 28, compared with the control group, the pain thresholds of the EA and AK groups were not statistically different. However, the pain threshold of the model group was significantly lower than the control group. On days 21 and 28, compared with the model group, the pain threshold of the AK group rose significantly (P < 0.05). From days 35 to 56, there was no significant difference between all four groups. However, Figure 1 shows a similar pain threshold between the control, EA, and AK group, which is higher than that of the model group.


Effects of acupuncture knife on inflammatory factors and pain in third lumbar vertebrae transverse process syndrome model rats.

Yu JN, Guo CQ, Hu B, Liu NG, Sun HM, Xu H, Wu HX, Guo Y, Liang CX, Chen ZX, Li XH - Evid Based Complement Alternat Med (2014)

Effects of pain threshold on tail flick test in each group (n = 10 per group): control, model, EA, and AK. Compared with the control group, *P < 0.01, **P < 0.05. Compared with the model group, #P < 0.05.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4269310&req=5

fig2: Effects of pain threshold on tail flick test in each group (n = 10 per group): control, model, EA, and AK. Compared with the control group, *P < 0.01, **P < 0.05. Compared with the model group, #P < 0.05.
Mentions: The results of the pain threshold of tail flick test are shown in Figure 2. The pain threshold of the control group at different time points did not show obvious changes. The other three groups showed lower pain threshold from the second day after the operation. At 14 days, the day before performing treatment, compared with the control group, the model, EA, and AK group had a lower pain threshold (P < 0.01 or P < 0.05) and there were no statistical differences between the model, EA, and AK groups. After treatments, the pain threshold of the EA and AK group rose. From days 17 to 28, compared with the control group, the pain thresholds of the EA and AK groups were not statistically different. However, the pain threshold of the model group was significantly lower than the control group. On days 21 and 28, compared with the model group, the pain threshold of the AK group rose significantly (P < 0.05). From days 35 to 56, there was no significant difference between all four groups. However, Figure 1 shows a similar pain threshold between the control, EA, and AK group, which is higher than that of the model group.

Bottom Line: The aim of this paper was to explore the long-term effects and pain relief mechanism of acupuncture knife on third lumbar vertebrae (L3) transverse process syndrome.The tail flick test was used to observe pain threshold.AK pretreatment could alleviate pain through modulating inflammatory response.

View Article: PubMed Central - PubMed

Affiliation: School of Acupuncture and Moxibustion, Beijing University of Chinese Medicine, No. 11 North 3rd Ring East Road, Chaoyang District, Beijing 100029, China.

ABSTRACT
The aim of this paper was to explore the long-term effects and pain relief mechanism of acupuncture knife on third lumbar vertebrae (L3) transverse process syndrome. Forty SD rats were randomized into control, model, electroacupuncture (EA), and acupuncture knife (AK) group. Except control rats, other rats were subjected to an operation to emulate L3 transverse process syndrome. Fourteen days after the operation, EA and AK rats were given electroacupuncture and acupuncture knife treatments, respectively. Fifty-six days after the operation, enzyme-linked immunosorbent assay was used to measure substance P (SP), 5-hydroxytryptamine (5-HT), interleukin-1β (IL-1β), interleukin-10 (IL-10), tumor necrosis factor-α (TNF-α), and transforming growth factor-β (TGF-β) in peripheral blood. The tail flick test was used to observe pain threshold. We found that rats with the simulation operation had significantly higher levels of SP, 5-HT, IL-1, IL-10, TNF-α, and TGF-β, while the AK rats had lower levels. In addition, the pain threshold of AK rats was similar to that of control rats. AK pretreatment could alleviate pain through modulating inflammatory response.

No MeSH data available.


Related in: MedlinePlus