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Follicular lymphoma presenting with leptomeningeal disease.

Costa R, Costa R, Costa R - Case Rep Hematol (2014)

Bottom Line: Follicular lymphoma is generally an indolent B cell lymphoproliferative disorder of transformed follicular center B cells.Central nervous system metastasis is a very rare complication portending a very poor prognosis.We report a rare case of follicular lymphoma presenting with leptomeningeal involvement achieving a complete remission after initial therapy.

View Article: PubMed Central - PubMed

Affiliation: Cedar Valley Cancer Center, 3530 West 4th Street, Waterloo, IA 50701, USA.

ABSTRACT
Follicular lymphoma is generally an indolent B cell lymphoproliferative disorder of transformed follicular center B cells. Central nervous system metastasis is a very rare complication portending a very poor prognosis. We report a rare case of follicular lymphoma presenting with leptomeningeal involvement achieving a complete remission after initial therapy.

No MeSH data available.


Related in: MedlinePlus

Lymphoid cells strongly expressing CD23.
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Related In: Results  -  Collection


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fig4: Lymphoid cells strongly expressing CD23.

Mentions: A right inguinal lymph node biopsy showed variable degree of nodular proliferation of atypical lymphoid cell proliferation composed predominantly of centrocytes with admixed scattered centroblasts (approximately ten per high power field). The neoplastic nodules were positive for CD20, CD10, bcl-6, and bcl-2. Ki-67 highlighted approximately 10–20% of neoplastic lymphoid cells. The cells stained positive for CD23 confirming a follicular origin (Figure 3). Flow cytometry analysis revealed a CD10 positive, CD19, CD20 positive, kappa immunoglobulin light chain restricted B cell population. The results were consistent with follicular lymphoma grade 2 (Figure 4). A bone marrow biopsy was not performed.


Follicular lymphoma presenting with leptomeningeal disease.

Costa R, Costa R, Costa R - Case Rep Hematol (2014)

Lymphoid cells strongly expressing CD23.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4269308&req=5

fig4: Lymphoid cells strongly expressing CD23.
Mentions: A right inguinal lymph node biopsy showed variable degree of nodular proliferation of atypical lymphoid cell proliferation composed predominantly of centrocytes with admixed scattered centroblasts (approximately ten per high power field). The neoplastic nodules were positive for CD20, CD10, bcl-6, and bcl-2. Ki-67 highlighted approximately 10–20% of neoplastic lymphoid cells. The cells stained positive for CD23 confirming a follicular origin (Figure 3). Flow cytometry analysis revealed a CD10 positive, CD19, CD20 positive, kappa immunoglobulin light chain restricted B cell population. The results were consistent with follicular lymphoma grade 2 (Figure 4). A bone marrow biopsy was not performed.

Bottom Line: Follicular lymphoma is generally an indolent B cell lymphoproliferative disorder of transformed follicular center B cells.Central nervous system metastasis is a very rare complication portending a very poor prognosis.We report a rare case of follicular lymphoma presenting with leptomeningeal involvement achieving a complete remission after initial therapy.

View Article: PubMed Central - PubMed

Affiliation: Cedar Valley Cancer Center, 3530 West 4th Street, Waterloo, IA 50701, USA.

ABSTRACT
Follicular lymphoma is generally an indolent B cell lymphoproliferative disorder of transformed follicular center B cells. Central nervous system metastasis is a very rare complication portending a very poor prognosis. We report a rare case of follicular lymphoma presenting with leptomeningeal involvement achieving a complete remission after initial therapy.

No MeSH data available.


Related in: MedlinePlus