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A rare case of splenic marginal zone B-cell lymphoma mimicking relapsing polychondritis of the ear.

Huang GJ, Mendes B, Sheykholeslami K - Case Rep Otolaryngol (2014)

Bottom Line: However, RPC has also been linked to more insidious conditions such as malignancies, autoimmune disorders, vasculitis, or underlying infections.Given the spectrum of associated disorders, patients with RPC may need to be monitored for more insidious underlying conditions.In this case, we report a unique case of bilateral auricular inflammation and nasal inflammation mimicking RPC as the only presenting symptom of splenic marginal zone B-cell lymphoma and we survey related cases in the literature.

View Article: PubMed Central - PubMed

Affiliation: OSF Saint Anthony Health System, Department of Surgery, University of Illinois College of Medicine at Rockford, Rockford, IL 61103, USA.

ABSTRACT
Relapsing polychondritis (RPC) is a poorly understood phenomenon associated with cartilaginous inflammation of the ear, nose, tracheobronchial tree, and peripheral joints. Many cases of RPC respond to anti-inflammatories and resolve with no further complications. However, RPC has also been linked to more insidious conditions such as malignancies, autoimmune disorders, vasculitis, or underlying infections. Given the spectrum of associated disorders, patients with RPC may need to be monitored for more insidious underlying conditions. In this case, we report a unique case of bilateral auricular inflammation and nasal inflammation mimicking RPC as the only presenting symptom of splenic marginal zone B-cell lymphoma and we survey related cases in the literature.

No MeSH data available.


Related in: MedlinePlus

Hematoxylin and Eosin stain, light microscopy 10 × 40 (a), 10 × 40 (b).
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Related In: Results  -  Collection


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fig4: Hematoxylin and Eosin stain, light microscopy 10 × 40 (a), 10 × 40 (b).

Mentions: Surgical pathology (Figures 3, 4, 5, and 6) showed atypical diffuse lymphoid infiltrate of the superficial and deep dermis favoring low grade B-cell lymphoma, marginal zone subtype. Ki-67 proliferation index showed 10% of tumor cells with positive nuclear stain. Immunohistochemistry staining was equivocal for CD20, BCL-2, and CD45. Staining was negative for CD3, CD5, CD10, CD23, CD30, and cyclin D1. Outside consultation agreed with the diagnosis. Clinical correlation by hematology and oncology indicated a diagnosis of likely primary cutaneous marginal zone lymphoma (PCMZL) with plasmacytic differentiation. Oncology ordered a colonoscopy, esophagogastroduodenoscopy, staging CT scan of the chest and pelvis, and a trial of Rituxin (Rituximab).


A rare case of splenic marginal zone B-cell lymphoma mimicking relapsing polychondritis of the ear.

Huang GJ, Mendes B, Sheykholeslami K - Case Rep Otolaryngol (2014)

Hematoxylin and Eosin stain, light microscopy 10 × 40 (a), 10 × 40 (b).
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4269282&req=5

fig4: Hematoxylin and Eosin stain, light microscopy 10 × 40 (a), 10 × 40 (b).
Mentions: Surgical pathology (Figures 3, 4, 5, and 6) showed atypical diffuse lymphoid infiltrate of the superficial and deep dermis favoring low grade B-cell lymphoma, marginal zone subtype. Ki-67 proliferation index showed 10% of tumor cells with positive nuclear stain. Immunohistochemistry staining was equivocal for CD20, BCL-2, and CD45. Staining was negative for CD3, CD5, CD10, CD23, CD30, and cyclin D1. Outside consultation agreed with the diagnosis. Clinical correlation by hematology and oncology indicated a diagnosis of likely primary cutaneous marginal zone lymphoma (PCMZL) with plasmacytic differentiation. Oncology ordered a colonoscopy, esophagogastroduodenoscopy, staging CT scan of the chest and pelvis, and a trial of Rituxin (Rituximab).

Bottom Line: However, RPC has also been linked to more insidious conditions such as malignancies, autoimmune disorders, vasculitis, or underlying infections.Given the spectrum of associated disorders, patients with RPC may need to be monitored for more insidious underlying conditions.In this case, we report a unique case of bilateral auricular inflammation and nasal inflammation mimicking RPC as the only presenting symptom of splenic marginal zone B-cell lymphoma and we survey related cases in the literature.

View Article: PubMed Central - PubMed

Affiliation: OSF Saint Anthony Health System, Department of Surgery, University of Illinois College of Medicine at Rockford, Rockford, IL 61103, USA.

ABSTRACT
Relapsing polychondritis (RPC) is a poorly understood phenomenon associated with cartilaginous inflammation of the ear, nose, tracheobronchial tree, and peripheral joints. Many cases of RPC respond to anti-inflammatories and resolve with no further complications. However, RPC has also been linked to more insidious conditions such as malignancies, autoimmune disorders, vasculitis, or underlying infections. Given the spectrum of associated disorders, patients with RPC may need to be monitored for more insidious underlying conditions. In this case, we report a unique case of bilateral auricular inflammation and nasal inflammation mimicking RPC as the only presenting symptom of splenic marginal zone B-cell lymphoma and we survey related cases in the literature.

No MeSH data available.


Related in: MedlinePlus