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ZEB1 expression in endometrial biopsy predicts lymph node metastases in patient with endometrial cancer.

Feng G, Wang X, Cao X, Shen L, Zhu J - Dis. Markers (2014)

Bottom Line: The relationship between ZEB1 expression and preoperative characteristics was analyzed.ZEB1 expressions were significantly associated with subtype, grade, myometrial invasion, and lymph node metastases.Based on combination of preoperative characteristics and ZEB1 expression, lymph node metastases could be identified with a sensitivity of 62.1% at specificity of 96.2% prior to hysterectomy.

View Article: PubMed Central - PubMed

Affiliation: Clinical Genetics Laboratory, The First Affiliated Hospital of Wannan Medical College, Wuhu, Anhui 241001, China.

ABSTRACT

Purpose: The purpose of this study was to analyze the expression of zinc-finger E-box-binding homeobox 1 (ZEB1) in endometrial biopsy and its correlation with preoperative characteristics, including lymph node metastases in patient with endometrial cancer.

Methods: Using quantitative RT-PCR, ZEB1 expressions in endometrial biopsy from 452 patients were measured. The relationship between ZEB1 expression and preoperative characteristics was analyzed.

Results: ZEB1 expressions were significantly associated with subtype, grade, myometrial invasion, and lymph node metastases. Lymph node metastases could be identified with a sensitivity of 57.8% at specificity of 74.1% by ZEB1 expression in endometrial biopsy. Based on combination of preoperative characteristics and ZEB1 expression, lymph node metastases could be identified with a sensitivity of 62.1% at specificity of 96.2% prior to hysterectomy.

Conclusion: ZEB1 expression in endometrial biopsy could help physicians to better predict the lymph node metastasis in patients with endometrial cancer prior to hysterectomy.

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Related in: MedlinePlus

Receiver operating characteristic (ROC) curve of ZEB1 expression in endometrial biopsy for predicting lymph node metastasis in patient with endometrial cancer. The area under the curve (AUC) was 0.657 (95% CI: 0.541–0.774). The best cut-off value was 4.92 (sensitivity: 57.8%; specificity: 74.1%).
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fig1: Receiver operating characteristic (ROC) curve of ZEB1 expression in endometrial biopsy for predicting lymph node metastasis in patient with endometrial cancer. The area under the curve (AUC) was 0.657 (95% CI: 0.541–0.774). The best cut-off value was 4.92 (sensitivity: 57.8%; specificity: 74.1%).

Mentions: Between ZEB1 expression in patients with lymph node metastasis (5.31 ± 3.15) and without lymph node metastasis (3.37 ± 3.02), a significant difference has been found (P < 0.001). ROC analyses of ZEB1 expression in patients with and without lymph node metastasis are shown in Figure 1. In this study population, the best cut-off point for ZEB1 expression was 4.92. ZEB1 expression greater than 4.92 demonstrated a sensitivity and specificity of 57.8% and 74.1%, respectively, for lymph node metastasis (ROC AUC = 0.657; 95% CI, 0.541–0.774). Based on the combination of preoperative characteristics and ZEB1 expression, lymph node metastases could be identified with a sensitivity of 62.1% at specificity of 96.2% (Table 4).


ZEB1 expression in endometrial biopsy predicts lymph node metastases in patient with endometrial cancer.

Feng G, Wang X, Cao X, Shen L, Zhu J - Dis. Markers (2014)

Receiver operating characteristic (ROC) curve of ZEB1 expression in endometrial biopsy for predicting lymph node metastasis in patient with endometrial cancer. The area under the curve (AUC) was 0.657 (95% CI: 0.541–0.774). The best cut-off value was 4.92 (sensitivity: 57.8%; specificity: 74.1%).
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4269209&req=5

fig1: Receiver operating characteristic (ROC) curve of ZEB1 expression in endometrial biopsy for predicting lymph node metastasis in patient with endometrial cancer. The area under the curve (AUC) was 0.657 (95% CI: 0.541–0.774). The best cut-off value was 4.92 (sensitivity: 57.8%; specificity: 74.1%).
Mentions: Between ZEB1 expression in patients with lymph node metastasis (5.31 ± 3.15) and without lymph node metastasis (3.37 ± 3.02), a significant difference has been found (P < 0.001). ROC analyses of ZEB1 expression in patients with and without lymph node metastasis are shown in Figure 1. In this study population, the best cut-off point for ZEB1 expression was 4.92. ZEB1 expression greater than 4.92 demonstrated a sensitivity and specificity of 57.8% and 74.1%, respectively, for lymph node metastasis (ROC AUC = 0.657; 95% CI, 0.541–0.774). Based on the combination of preoperative characteristics and ZEB1 expression, lymph node metastases could be identified with a sensitivity of 62.1% at specificity of 96.2% (Table 4).

Bottom Line: The relationship between ZEB1 expression and preoperative characteristics was analyzed.ZEB1 expressions were significantly associated with subtype, grade, myometrial invasion, and lymph node metastases.Based on combination of preoperative characteristics and ZEB1 expression, lymph node metastases could be identified with a sensitivity of 62.1% at specificity of 96.2% prior to hysterectomy.

View Article: PubMed Central - PubMed

Affiliation: Clinical Genetics Laboratory, The First Affiliated Hospital of Wannan Medical College, Wuhu, Anhui 241001, China.

ABSTRACT

Purpose: The purpose of this study was to analyze the expression of zinc-finger E-box-binding homeobox 1 (ZEB1) in endometrial biopsy and its correlation with preoperative characteristics, including lymph node metastases in patient with endometrial cancer.

Methods: Using quantitative RT-PCR, ZEB1 expressions in endometrial biopsy from 452 patients were measured. The relationship between ZEB1 expression and preoperative characteristics was analyzed.

Results: ZEB1 expressions were significantly associated with subtype, grade, myometrial invasion, and lymph node metastases. Lymph node metastases could be identified with a sensitivity of 57.8% at specificity of 74.1% by ZEB1 expression in endometrial biopsy. Based on combination of preoperative characteristics and ZEB1 expression, lymph node metastases could be identified with a sensitivity of 62.1% at specificity of 96.2% prior to hysterectomy.

Conclusion: ZEB1 expression in endometrial biopsy could help physicians to better predict the lymph node metastasis in patients with endometrial cancer prior to hysterectomy.

Show MeSH
Related in: MedlinePlus