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Exercise Hemodynamics and Quality of Life after Aortic Valve Replacement for Aortic Stenosis in the Elderly Using the Hancock II Bioprosthesis.

Long T, Lopez BM, Berberian C, Cunningham MJ, Starnes VA, Cohen RG - Cardiol Res Pract (2014)

Bottom Line: Results.Patients were found to have significant improvements (P ≤ 0.01) in six of the nine SF-36 health parameters.Conclusions.

View Article: PubMed Central - PubMed

Affiliation: Robert Wood Johnson Clinical Scholars Program, Department of Internal Medicine, Yale School of Medicine, New Haven, CT 06520, USA.

ABSTRACT
Background and Aim. While aortic valve replacement for aortic stenosis can be performed safely in elderly patients, there is a need for hemodynamic and quality of life evaluation to determine the value of aortic valve replacement in older patients who may have age-related activity limitation. Materials and Methods. We conducted a prospective evaluation of patients who underwent aortic valve replacement for aortic stenosis with the Hancock II porcine bioprosthesis. All patients underwent transthoracic echocardiography (TTE) and completed the RAND 36-Item Health Survey (SF-36) preoperatively and six months postoperatively. Results. From 2004 to 2007, 33 patients were enrolled with an average age of 75.3 ± 5.3 years (24 men and 9 women). Preoperatively, 27/33 (82%) were New York Heart Association (NYHA) Functional Classification 3, and postoperatively 27/33 (82%) were NYHA Functional Classification 1. Patients had a mean predicted maximum V O2 (mL/kg/min) of 19.5 ± 4.3 and an actual max V O2 of 15.5 ± 3.9, which was 80% of the predicted V O2 . Patients were found to have significant improvements (P ≤ 0.01) in six of the nine SF-36 health parameters. Conclusions. In our sample of elderly patients with aortic stenosis, replacing the aortic valve with a Hancock II bioprosthesis resulted in improved hemodynamics and quality of life.

No MeSH data available.


Related in: MedlinePlus

Max VO2 and anaerobic threshold.
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fig2: Max VO2 and anaerobic threshold.

Mentions: Patients had a mean predicted maximum VO2 (mL/kg/min) of 19.5 ± 4.3 and an actual max VO2 of 15.5 ± 3.9, which was 80% of the predicted VO2. The expected maximum VO2 used for a healthy 75-year-old person was 19 mL/kg/min predicted and 15 mL/kg/min actual, resulting in 80% of the predicted VO2 for a healthy subject [6, 9]. The max VO2 values for our patients are displayed in Figure 2. AT greater than 55% of the max VO2 is thought to be a normal response [10, 11].


Exercise Hemodynamics and Quality of Life after Aortic Valve Replacement for Aortic Stenosis in the Elderly Using the Hancock II Bioprosthesis.

Long T, Lopez BM, Berberian C, Cunningham MJ, Starnes VA, Cohen RG - Cardiol Res Pract (2014)

Max VO2 and anaerobic threshold.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4269201&req=5

fig2: Max VO2 and anaerobic threshold.
Mentions: Patients had a mean predicted maximum VO2 (mL/kg/min) of 19.5 ± 4.3 and an actual max VO2 of 15.5 ± 3.9, which was 80% of the predicted VO2. The expected maximum VO2 used for a healthy 75-year-old person was 19 mL/kg/min predicted and 15 mL/kg/min actual, resulting in 80% of the predicted VO2 for a healthy subject [6, 9]. The max VO2 values for our patients are displayed in Figure 2. AT greater than 55% of the max VO2 is thought to be a normal response [10, 11].

Bottom Line: Results.Patients were found to have significant improvements (P ≤ 0.01) in six of the nine SF-36 health parameters.Conclusions.

View Article: PubMed Central - PubMed

Affiliation: Robert Wood Johnson Clinical Scholars Program, Department of Internal Medicine, Yale School of Medicine, New Haven, CT 06520, USA.

ABSTRACT
Background and Aim. While aortic valve replacement for aortic stenosis can be performed safely in elderly patients, there is a need for hemodynamic and quality of life evaluation to determine the value of aortic valve replacement in older patients who may have age-related activity limitation. Materials and Methods. We conducted a prospective evaluation of patients who underwent aortic valve replacement for aortic stenosis with the Hancock II porcine bioprosthesis. All patients underwent transthoracic echocardiography (TTE) and completed the RAND 36-Item Health Survey (SF-36) preoperatively and six months postoperatively. Results. From 2004 to 2007, 33 patients were enrolled with an average age of 75.3 ± 5.3 years (24 men and 9 women). Preoperatively, 27/33 (82%) were New York Heart Association (NYHA) Functional Classification 3, and postoperatively 27/33 (82%) were NYHA Functional Classification 1. Patients had a mean predicted maximum V O2 (mL/kg/min) of 19.5 ± 4.3 and an actual max V O2 of 15.5 ± 3.9, which was 80% of the predicted V O2 . Patients were found to have significant improvements (P ≤ 0.01) in six of the nine SF-36 health parameters. Conclusions. In our sample of elderly patients with aortic stenosis, replacing the aortic valve with a Hancock II bioprosthesis resulted in improved hemodynamics and quality of life.

No MeSH data available.


Related in: MedlinePlus