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Predicting intracerebral hemorrhage by baseline magnetic resonance imaging in stroke patients undergoing systemic thrombolysis.

Hobohm C, Fritzsch D, Budig S, Classen J, Hoffmann KT, Michalski D - Acta Neurol. Scand. (2014)

Bottom Line: FLAIR-positive lesions were associated with a bleeding rate of 80.0% compared with 16.7% in FLAIR-negative patients (P < 0.001; odds ratio 20.0, positive predictive value 0.8).DWI lesion size was significantly correlated with the rate of ICH (P = 0.001).In contrast, FLAIR/DWI proportion was not associated with ICH (P = 0.788).

View Article: PubMed Central - PubMed

Affiliation: Department of Neurology, University of Leipzig, Leipzig, Germany.

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Rate of any intracerebral hemorrhage detected on computed tomography within 24 after systemic thrombolysis depending on initial lesion size as assessed by diffusion-weighted imaging (DWI) in relation to the vascular territory. For practical reasons, patients were allocated to the three groups ‘DWI < 1/3’, ‘DWI 1/3–2/3’ and ‘DWI > 2/3’. For illustration, a representative DWI sequence taken from the magnetic resonance imaging prior to treatment was added under each category. P indicates level of statistical significance.
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fig03: Rate of any intracerebral hemorrhage detected on computed tomography within 24 after systemic thrombolysis depending on initial lesion size as assessed by diffusion-weighted imaging (DWI) in relation to the vascular territory. For practical reasons, patients were allocated to the three groups ‘DWI < 1/3’, ‘DWI 1/3–2/3’ and ‘DWI > 2/3’. For illustration, a representative DWI sequence taken from the magnetic resonance imaging prior to treatment was added under each category. P indicates level of statistical significance.

Mentions: To explore the impact of DWI lesion size on treatment-associated hemorrhage, patients were stratified to the following groups depending on the proportion of DWI-restricted area with reference to the whole supplying territory of the affected cerebral artery: <1/3 (n = 62), 1/3–2/3 (n = 18) and >2/3 (n = 17). As shown in Fig.3, the occurrence of ICH was found to be clearly associated with the size of DWI lesion while patients exhibiting of at least 1/3 of the respective territory are characterized with an increased bleeding rate (P = 0.001, Pearson's chi-squared test). Overall, the provided categories for DWI lesion size significantly predicted ICH with an odds ratio of 5.6 (95% CI: 2.2–13.9).


Predicting intracerebral hemorrhage by baseline magnetic resonance imaging in stroke patients undergoing systemic thrombolysis.

Hobohm C, Fritzsch D, Budig S, Classen J, Hoffmann KT, Michalski D - Acta Neurol. Scand. (2014)

Rate of any intracerebral hemorrhage detected on computed tomography within 24 after systemic thrombolysis depending on initial lesion size as assessed by diffusion-weighted imaging (DWI) in relation to the vascular territory. For practical reasons, patients were allocated to the three groups ‘DWI < 1/3’, ‘DWI 1/3–2/3’ and ‘DWI > 2/3’. For illustration, a representative DWI sequence taken from the magnetic resonance imaging prior to treatment was added under each category. P indicates level of statistical significance.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4269181&req=5

fig03: Rate of any intracerebral hemorrhage detected on computed tomography within 24 after systemic thrombolysis depending on initial lesion size as assessed by diffusion-weighted imaging (DWI) in relation to the vascular territory. For practical reasons, patients were allocated to the three groups ‘DWI < 1/3’, ‘DWI 1/3–2/3’ and ‘DWI > 2/3’. For illustration, a representative DWI sequence taken from the magnetic resonance imaging prior to treatment was added under each category. P indicates level of statistical significance.
Mentions: To explore the impact of DWI lesion size on treatment-associated hemorrhage, patients were stratified to the following groups depending on the proportion of DWI-restricted area with reference to the whole supplying territory of the affected cerebral artery: <1/3 (n = 62), 1/3–2/3 (n = 18) and >2/3 (n = 17). As shown in Fig.3, the occurrence of ICH was found to be clearly associated with the size of DWI lesion while patients exhibiting of at least 1/3 of the respective territory are characterized with an increased bleeding rate (P = 0.001, Pearson's chi-squared test). Overall, the provided categories for DWI lesion size significantly predicted ICH with an odds ratio of 5.6 (95% CI: 2.2–13.9).

Bottom Line: FLAIR-positive lesions were associated with a bleeding rate of 80.0% compared with 16.7% in FLAIR-negative patients (P < 0.001; odds ratio 20.0, positive predictive value 0.8).DWI lesion size was significantly correlated with the rate of ICH (P = 0.001).In contrast, FLAIR/DWI proportion was not associated with ICH (P = 0.788).

View Article: PubMed Central - PubMed

Affiliation: Department of Neurology, University of Leipzig, Leipzig, Germany.

Show MeSH
Related in: MedlinePlus