Predicting intracerebral hemorrhage by baseline magnetic resonance imaging in stroke patients undergoing systemic thrombolysis.
Bottom Line: FLAIR-positive lesions were associated with a bleeding rate of 80.0% compared with 16.7% in FLAIR-negative patients (P < 0.001; odds ratio 20.0, positive predictive value 0.8).DWI lesion size was significantly correlated with the rate of ICH (P = 0.001).In contrast, FLAIR/DWI proportion was not associated with ICH (P = 0.788).
Affiliation: Department of Neurology, University of Leipzig, Leipzig, Germany.Show MeSH
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Mentions: To explore the impact of DWI lesion size on treatment-associated hemorrhage, patients were stratified to the following groups depending on the proportion of DWI-restricted area with reference to the whole supplying territory of the affected cerebral artery: <1/3 (n = 62), 1/3–2/3 (n = 18) and >2/3 (n = 17). As shown in Fig.3, the occurrence of ICH was found to be clearly associated with the size of DWI lesion while patients exhibiting of at least 1/3 of the respective territory are characterized with an increased bleeding rate (P = 0.001, Pearson's chi-squared test). Overall, the provided categories for DWI lesion size significantly predicted ICH with an odds ratio of 5.6 (95% CI: 2.2–13.9).
Affiliation: Department of Neurology, University of Leipzig, Leipzig, Germany.