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Malouf syndrome with hypergonadotropic hypogonadism and cardiomyopathy: two-case report and literature review.

Şilfeler DB, Karateke A, Keskin Kurt R, Aldemir Ö, Buğra Nacar A, Baloğlu A - Case Rep Obstet Gynecol (2014)

Bottom Line: Malouf syndrome is a very rarely encountered syndrome which was first diagnosed in 1985 upon the examination of two sisters, with findings of hypergonadotropic hypogonadism, dilated cardiomyopathy, blepharoptosis, and broad nasal base.Later on, Narahara diagnosed another sporadic case with the same findings.A survey of relevant literature leads us to three women cases in total.

View Article: PubMed Central - PubMed

Affiliation: Department of Obstetrics and Gynecology, Mustafa Kemal University Medical School, Hatay, Turkey.

ABSTRACT
Malouf syndrome is a very rarely encountered syndrome which was first diagnosed in 1985 upon the examination of two sisters, with findings of hypergonadotropic hypogonadism, dilated cardiomyopathy, blepharoptosis, and broad nasal base. Later on, Narahara diagnosed another sporadic case with the same findings. A survey of relevant literature leads us to three women cases in total. Here we present two cases of Malouf syndrome and literature review.

No MeSH data available.


Related in: MedlinePlus

Pedigree.
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fig3: Pedigree.

Mentions: Malouf and his colleagues diagnosed two sisters and stated that the parents of these sisters were first-degree cousins. In their family story, there is also a mention of the death of two brothers, approximately at the age of eighteen, due to cardiac insufficiency [1]. As remarked in Pedigree, our cases also consist of siblings and cousins (Figure 3). There were also relationships between the parents of the cases. In addition, it was learnt from the detailed medical record that the second case had another sister, who was born in 1998 and died in 2005 due to sudden cardiac arrest. It was reported that the patient complained of dyspnea and fatigue and that she had swellings on her legs which were typical sign and symptoms of dilated cardiomyopathy. From the gynecological medical record, it was ascertained that the case had similar findings to her sister.


Malouf syndrome with hypergonadotropic hypogonadism and cardiomyopathy: two-case report and literature review.

Şilfeler DB, Karateke A, Keskin Kurt R, Aldemir Ö, Buğra Nacar A, Baloğlu A - Case Rep Obstet Gynecol (2014)

Pedigree.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4269178&req=5

fig3: Pedigree.
Mentions: Malouf and his colleagues diagnosed two sisters and stated that the parents of these sisters were first-degree cousins. In their family story, there is also a mention of the death of two brothers, approximately at the age of eighteen, due to cardiac insufficiency [1]. As remarked in Pedigree, our cases also consist of siblings and cousins (Figure 3). There were also relationships between the parents of the cases. In addition, it was learnt from the detailed medical record that the second case had another sister, who was born in 1998 and died in 2005 due to sudden cardiac arrest. It was reported that the patient complained of dyspnea and fatigue and that she had swellings on her legs which were typical sign and symptoms of dilated cardiomyopathy. From the gynecological medical record, it was ascertained that the case had similar findings to her sister.

Bottom Line: Malouf syndrome is a very rarely encountered syndrome which was first diagnosed in 1985 upon the examination of two sisters, with findings of hypergonadotropic hypogonadism, dilated cardiomyopathy, blepharoptosis, and broad nasal base.Later on, Narahara diagnosed another sporadic case with the same findings.A survey of relevant literature leads us to three women cases in total.

View Article: PubMed Central - PubMed

Affiliation: Department of Obstetrics and Gynecology, Mustafa Kemal University Medical School, Hatay, Turkey.

ABSTRACT
Malouf syndrome is a very rarely encountered syndrome which was first diagnosed in 1985 upon the examination of two sisters, with findings of hypergonadotropic hypogonadism, dilated cardiomyopathy, blepharoptosis, and broad nasal base. Later on, Narahara diagnosed another sporadic case with the same findings. A survey of relevant literature leads us to three women cases in total. Here we present two cases of Malouf syndrome and literature review.

No MeSH data available.


Related in: MedlinePlus