Limits...
Social stress increases expression of hemoglobin genes in mouse prefrontal cortex.

Stankiewicz AM, Goscik J, Swiergiel AH, Majewska A, Wieczorek M, Juszczak GR, Lisowski P - BMC Neurosci (2014)

Bottom Line: Chronic stress increased also expression of Timp1 and Ppbp that are involved in reaction to vascular injury.Acute stress did not affect expression of hemoglobin genes but it altered expression of Fam107a (Drr1) and Agxt2l1 (Etnppl) that have been implicated in psychiatric diseases.The observed up-regulation of genes associated with vascular system and brain injury suggests that stressful social encounters may affect brain function through the stress-induced dysfunction of the vascular system.

View Article: PubMed Central - PubMed

Affiliation: Department of Animal Behavior, Institute of Genetics and Animal Breeding, Jastrzebiec, ul. Postepu 36A, 05-552, Magdalenka, Poland. adrianstankiewicz85@gmail.com.

ABSTRACT

Background: In order to better understand the effects of social stress on the prefrontal cortex, we investigated gene expression in mice subjected to acute and repeated social encounters of different duration using microarrays.

Results: The most important finding was identification of hemoglobin genes (Hbb-b1, Hbb-b2, Hba-a1, Hba-a2, Beta-S) as potential markers of chronic social stress in mice. Expression of these genes was progressively increased in animals subjected to 8 and 13 days of repeated stress and was correlated with altered expression of Mgp (Mglap), Fbln1, 1500015O10Rik (Ecrg4), SLC16A10, and Mndal. Chronic stress increased also expression of Timp1 and Ppbp that are involved in reaction to vascular injury. Acute stress did not affect expression of hemoglobin genes but it altered expression of Fam107a (Drr1) and Agxt2l1 (Etnppl) that have been implicated in psychiatric diseases.

Conclusions: The observed up-regulation of genes associated with vascular system and brain injury suggests that stressful social encounters may affect brain function through the stress-induced dysfunction of the vascular system.

Show MeSH

Related in: MedlinePlus

Quantitative PCR validation of microarray data. Values are presented as Mean ± SEM. N = 11–12, * - p < 0.05, ** - p < 0.01; compared with corresponding control group.
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
getmorefigures.php?uid=PMC4269175&req=5

Fig9: Quantitative PCR validation of microarray data. Values are presented as Mean ± SEM. N = 11–12, * - p < 0.05, ** - p < 0.01; compared with corresponding control group.

Mentions: qPCR confirmed that Agxt2l1 and Fam107a were significantly up-regulated by acute stress, whereas Hbb-b1, Mgp and 1500015O10Rik were significantly up-regulated by chronic stress (Figure 9).Figure 9


Social stress increases expression of hemoglobin genes in mouse prefrontal cortex.

Stankiewicz AM, Goscik J, Swiergiel AH, Majewska A, Wieczorek M, Juszczak GR, Lisowski P - BMC Neurosci (2014)

Quantitative PCR validation of microarray data. Values are presented as Mean ± SEM. N = 11–12, * - p < 0.05, ** - p < 0.01; compared with corresponding control group.
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4269175&req=5

Fig9: Quantitative PCR validation of microarray data. Values are presented as Mean ± SEM. N = 11–12, * - p < 0.05, ** - p < 0.01; compared with corresponding control group.
Mentions: qPCR confirmed that Agxt2l1 and Fam107a were significantly up-regulated by acute stress, whereas Hbb-b1, Mgp and 1500015O10Rik were significantly up-regulated by chronic stress (Figure 9).Figure 9

Bottom Line: Chronic stress increased also expression of Timp1 and Ppbp that are involved in reaction to vascular injury.Acute stress did not affect expression of hemoglobin genes but it altered expression of Fam107a (Drr1) and Agxt2l1 (Etnppl) that have been implicated in psychiatric diseases.The observed up-regulation of genes associated with vascular system and brain injury suggests that stressful social encounters may affect brain function through the stress-induced dysfunction of the vascular system.

View Article: PubMed Central - PubMed

Affiliation: Department of Animal Behavior, Institute of Genetics and Animal Breeding, Jastrzebiec, ul. Postepu 36A, 05-552, Magdalenka, Poland. adrianstankiewicz85@gmail.com.

ABSTRACT

Background: In order to better understand the effects of social stress on the prefrontal cortex, we investigated gene expression in mice subjected to acute and repeated social encounters of different duration using microarrays.

Results: The most important finding was identification of hemoglobin genes (Hbb-b1, Hbb-b2, Hba-a1, Hba-a2, Beta-S) as potential markers of chronic social stress in mice. Expression of these genes was progressively increased in animals subjected to 8 and 13 days of repeated stress and was correlated with altered expression of Mgp (Mglap), Fbln1, 1500015O10Rik (Ecrg4), SLC16A10, and Mndal. Chronic stress increased also expression of Timp1 and Ppbp that are involved in reaction to vascular injury. Acute stress did not affect expression of hemoglobin genes but it altered expression of Fam107a (Drr1) and Agxt2l1 (Etnppl) that have been implicated in psychiatric diseases.

Conclusions: The observed up-regulation of genes associated with vascular system and brain injury suggests that stressful social encounters may affect brain function through the stress-induced dysfunction of the vascular system.

Show MeSH
Related in: MedlinePlus