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Social stress increases expression of hemoglobin genes in mouse prefrontal cortex.

Stankiewicz AM, Goscik J, Swiergiel AH, Majewska A, Wieczorek M, Juszczak GR, Lisowski P - BMC Neurosci (2014)

Bottom Line: Chronic stress increased also expression of Timp1 and Ppbp that are involved in reaction to vascular injury.Acute stress did not affect expression of hemoglobin genes but it altered expression of Fam107a (Drr1) and Agxt2l1 (Etnppl) that have been implicated in psychiatric diseases.The observed up-regulation of genes associated with vascular system and brain injury suggests that stressful social encounters may affect brain function through the stress-induced dysfunction of the vascular system.

View Article: PubMed Central - PubMed

Affiliation: Department of Animal Behavior, Institute of Genetics and Animal Breeding, Jastrzebiec, ul. Postepu 36A, 05-552, Magdalenka, Poland. adrianstankiewicz85@gmail.com.

ABSTRACT

Background: In order to better understand the effects of social stress on the prefrontal cortex, we investigated gene expression in mice subjected to acute and repeated social encounters of different duration using microarrays.

Results: The most important finding was identification of hemoglobin genes (Hbb-b1, Hbb-b2, Hba-a1, Hba-a2, Beta-S) as potential markers of chronic social stress in mice. Expression of these genes was progressively increased in animals subjected to 8 and 13 days of repeated stress and was correlated with altered expression of Mgp (Mglap), Fbln1, 1500015O10Rik (Ecrg4), SLC16A10, and Mndal. Chronic stress increased also expression of Timp1 and Ppbp that are involved in reaction to vascular injury. Acute stress did not affect expression of hemoglobin genes but it altered expression of Fam107a (Drr1) and Agxt2l1 (Etnppl) that have been implicated in psychiatric diseases.

Conclusions: The observed up-regulation of genes associated with vascular system and brain injury suggests that stressful social encounters may affect brain function through the stress-induced dysfunction of the vascular system.

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Related in: MedlinePlus

Correlation between expression of genes affected by chronic stress (13 days) and weight of thymus (A, C, D), spleen (B) and adrenal glands (E) calculated per 1 g of body weight. Correlation between Mgp, 1500015O10Rik and Hbb-b1 is presented in panel F, G and H. C + S denotes that presented are data from both contron and stressed animals, S denotes correlation only within stress group.
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Fig11: Correlation between expression of genes affected by chronic stress (13 days) and weight of thymus (A, C, D), spleen (B) and adrenal glands (E) calculated per 1 g of body weight. Correlation between Mgp, 1500015O10Rik and Hbb-b1 is presented in panel F, G and H. C + S denotes that presented are data from both contron and stressed animals, S denotes correlation only within stress group.

Mentions: Thymic weight was negatively correlated with expression of Hbb-b1 and Mgp (Figure 11A and D) while weight spleen was positively correlated with expression of Hbb-b1 (Figure 11B). Weight of adrenal glands correlated positively with expression of Mgp but this effect was significant only within the stress group (Figure 11E). There was also a significant correlation between expression of Hbb-b1, Mgp and 1500015O10Rik (Figure 11F,G and H). Other correlations were not significant (Additional file 2).Figure 11


Social stress increases expression of hemoglobin genes in mouse prefrontal cortex.

Stankiewicz AM, Goscik J, Swiergiel AH, Majewska A, Wieczorek M, Juszczak GR, Lisowski P - BMC Neurosci (2014)

Correlation between expression of genes affected by chronic stress (13 days) and weight of thymus (A, C, D), spleen (B) and adrenal glands (E) calculated per 1 g of body weight. Correlation between Mgp, 1500015O10Rik and Hbb-b1 is presented in panel F, G and H. C + S denotes that presented are data from both contron and stressed animals, S denotes correlation only within stress group.
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4269175&req=5

Fig11: Correlation between expression of genes affected by chronic stress (13 days) and weight of thymus (A, C, D), spleen (B) and adrenal glands (E) calculated per 1 g of body weight. Correlation between Mgp, 1500015O10Rik and Hbb-b1 is presented in panel F, G and H. C + S denotes that presented are data from both contron and stressed animals, S denotes correlation only within stress group.
Mentions: Thymic weight was negatively correlated with expression of Hbb-b1 and Mgp (Figure 11A and D) while weight spleen was positively correlated with expression of Hbb-b1 (Figure 11B). Weight of adrenal glands correlated positively with expression of Mgp but this effect was significant only within the stress group (Figure 11E). There was also a significant correlation between expression of Hbb-b1, Mgp and 1500015O10Rik (Figure 11F,G and H). Other correlations were not significant (Additional file 2).Figure 11

Bottom Line: Chronic stress increased also expression of Timp1 and Ppbp that are involved in reaction to vascular injury.Acute stress did not affect expression of hemoglobin genes but it altered expression of Fam107a (Drr1) and Agxt2l1 (Etnppl) that have been implicated in psychiatric diseases.The observed up-regulation of genes associated with vascular system and brain injury suggests that stressful social encounters may affect brain function through the stress-induced dysfunction of the vascular system.

View Article: PubMed Central - PubMed

Affiliation: Department of Animal Behavior, Institute of Genetics and Animal Breeding, Jastrzebiec, ul. Postepu 36A, 05-552, Magdalenka, Poland. adrianstankiewicz85@gmail.com.

ABSTRACT

Background: In order to better understand the effects of social stress on the prefrontal cortex, we investigated gene expression in mice subjected to acute and repeated social encounters of different duration using microarrays.

Results: The most important finding was identification of hemoglobin genes (Hbb-b1, Hbb-b2, Hba-a1, Hba-a2, Beta-S) as potential markers of chronic social stress in mice. Expression of these genes was progressively increased in animals subjected to 8 and 13 days of repeated stress and was correlated with altered expression of Mgp (Mglap), Fbln1, 1500015O10Rik (Ecrg4), SLC16A10, and Mndal. Chronic stress increased also expression of Timp1 and Ppbp that are involved in reaction to vascular injury. Acute stress did not affect expression of hemoglobin genes but it altered expression of Fam107a (Drr1) and Agxt2l1 (Etnppl) that have been implicated in psychiatric diseases.

Conclusions: The observed up-regulation of genes associated with vascular system and brain injury suggests that stressful social encounters may affect brain function through the stress-induced dysfunction of the vascular system.

Show MeSH
Related in: MedlinePlus