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Social stress increases expression of hemoglobin genes in mouse prefrontal cortex.

Stankiewicz AM, Goscik J, Swiergiel AH, Majewska A, Wieczorek M, Juszczak GR, Lisowski P - BMC Neurosci (2014)

Bottom Line: Chronic stress increased also expression of Timp1 and Ppbp that are involved in reaction to vascular injury.Acute stress did not affect expression of hemoglobin genes but it altered expression of Fam107a (Drr1) and Agxt2l1 (Etnppl) that have been implicated in psychiatric diseases.The observed up-regulation of genes associated with vascular system and brain injury suggests that stressful social encounters may affect brain function through the stress-induced dysfunction of the vascular system.

View Article: PubMed Central - PubMed

Affiliation: Department of Animal Behavior, Institute of Genetics and Animal Breeding, Jastrzebiec, ul. Postepu 36A, 05-552, Magdalenka, Poland. adrianstankiewicz85@gmail.com.

ABSTRACT

Background: In order to better understand the effects of social stress on the prefrontal cortex, we investigated gene expression in mice subjected to acute and repeated social encounters of different duration using microarrays.

Results: The most important finding was identification of hemoglobin genes (Hbb-b1, Hbb-b2, Hba-a1, Hba-a2, Beta-S) as potential markers of chronic social stress in mice. Expression of these genes was progressively increased in animals subjected to 8 and 13 days of repeated stress and was correlated with altered expression of Mgp (Mglap), Fbln1, 1500015O10Rik (Ecrg4), SLC16A10, and Mndal. Chronic stress increased also expression of Timp1 and Ppbp that are involved in reaction to vascular injury. Acute stress did not affect expression of hemoglobin genes but it altered expression of Fam107a (Drr1) and Agxt2l1 (Etnppl) that have been implicated in psychiatric diseases.

Conclusions: The observed up-regulation of genes associated with vascular system and brain injury suggests that stressful social encounters may affect brain function through the stress-induced dysfunction of the vascular system.

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Related in: MedlinePlus

Correlation between expression of genes affected by acute stress and weight of thymus (A) and spleen (B) calculated per 1 g of body weight. C + S denotes that presented are data from both control and stressed animals.
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Fig10: Correlation between expression of genes affected by acute stress and weight of thymus (A) and spleen (B) calculated per 1 g of body weight. C + S denotes that presented are data from both control and stressed animals.

Mentions: Thymic weight was negatively correlated with expression of Agxt2l1 and this relationship was significant for the pooled data containing results from the control and stressed mice (Figure 10A). Expression of Fam107a was positively correlated with weight of spleen and this relationship was significant both in case of pooled data (p < 0.001; Figure 10B) and within control (p < 0.05) and stress group (p < 0.01). Finally, there was also a correlation between weight of thymus and spleen in control group (p < 0.05). Other correlations were not significant (Additional file 2).Figure 10


Social stress increases expression of hemoglobin genes in mouse prefrontal cortex.

Stankiewicz AM, Goscik J, Swiergiel AH, Majewska A, Wieczorek M, Juszczak GR, Lisowski P - BMC Neurosci (2014)

Correlation between expression of genes affected by acute stress and weight of thymus (A) and spleen (B) calculated per 1 g of body weight. C + S denotes that presented are data from both control and stressed animals.
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4269175&req=5

Fig10: Correlation between expression of genes affected by acute stress and weight of thymus (A) and spleen (B) calculated per 1 g of body weight. C + S denotes that presented are data from both control and stressed animals.
Mentions: Thymic weight was negatively correlated with expression of Agxt2l1 and this relationship was significant for the pooled data containing results from the control and stressed mice (Figure 10A). Expression of Fam107a was positively correlated with weight of spleen and this relationship was significant both in case of pooled data (p < 0.001; Figure 10B) and within control (p < 0.05) and stress group (p < 0.01). Finally, there was also a correlation between weight of thymus and spleen in control group (p < 0.05). Other correlations were not significant (Additional file 2).Figure 10

Bottom Line: Chronic stress increased also expression of Timp1 and Ppbp that are involved in reaction to vascular injury.Acute stress did not affect expression of hemoglobin genes but it altered expression of Fam107a (Drr1) and Agxt2l1 (Etnppl) that have been implicated in psychiatric diseases.The observed up-regulation of genes associated with vascular system and brain injury suggests that stressful social encounters may affect brain function through the stress-induced dysfunction of the vascular system.

View Article: PubMed Central - PubMed

Affiliation: Department of Animal Behavior, Institute of Genetics and Animal Breeding, Jastrzebiec, ul. Postepu 36A, 05-552, Magdalenka, Poland. adrianstankiewicz85@gmail.com.

ABSTRACT

Background: In order to better understand the effects of social stress on the prefrontal cortex, we investigated gene expression in mice subjected to acute and repeated social encounters of different duration using microarrays.

Results: The most important finding was identification of hemoglobin genes (Hbb-b1, Hbb-b2, Hba-a1, Hba-a2, Beta-S) as potential markers of chronic social stress in mice. Expression of these genes was progressively increased in animals subjected to 8 and 13 days of repeated stress and was correlated with altered expression of Mgp (Mglap), Fbln1, 1500015O10Rik (Ecrg4), SLC16A10, and Mndal. Chronic stress increased also expression of Timp1 and Ppbp that are involved in reaction to vascular injury. Acute stress did not affect expression of hemoglobin genes but it altered expression of Fam107a (Drr1) and Agxt2l1 (Etnppl) that have been implicated in psychiatric diseases.

Conclusions: The observed up-regulation of genes associated with vascular system and brain injury suggests that stressful social encounters may affect brain function through the stress-induced dysfunction of the vascular system.

Show MeSH
Related in: MedlinePlus