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Impact of excess gestational and post-weaning energy intake on vascular function of swine offspring.

Taheripour P, DeFord MA, Arentson-Lantz EJ, Donkin SS, Ajuwon KM, Newcomer SC - BMC Pregnancy Childbirth (2014)

Bottom Line: Endothelial-dependent and -independent vasorelaxation was measured utilizing wire-myography and increasing concentrations of bradykinin (BK) and sodium nitroprusside (SNP), respectively.BK and SNP induced vasorelaxation were significantly reduced in the femoral arteries of gestational HE offspring.This dysfunction may lead to atherosclerotic disease development later in life.

View Article: PubMed Central - PubMed

Affiliation: Department of Health and Kinesiology, Purdue University, 3705 Chancellor Way, West Lafayette 47906, IN, USA. pardisd2@gmail.com.

ABSTRACT

Background: The development of long-term vascular disease can be linked to the intrauterine environment, and maternal nutrition during gestation plays a critical role in the future vascular health of offspring. The purpose of this investigation was to test the hypothesis that a high-energy (HE) gestational diet, HE post-weaning diet, or their combination will lead to endothelial dysfunction in offspring.

Methods: Duroc × Landrace gilts (n = 16) were assigned to either a HE (10,144 Kcal/day, n = 8) or normal energy (NE: 6721 Kcal/day, n = 8) diet throughout pregnancy. Piglets were placed on either a NE or HE diet during the growth phase. At 3 months of age femoral arteries were harvested from offspring (n = 47). Endothelial-dependent and -independent vasorelaxation was measured utilizing wire-myography and increasing concentrations of bradykinin (BK) and sodium nitroprusside (SNP), respectively.

Results: BK and SNP induced vasorelaxation were significantly reduced in the femoral arteries of gestational HE offspring. However, no effect for the post-weaning diet on BK and SNP induced vasorelaxation was seen. This investigation demonstrates that a HE diet prenatally diminishes both BK and SNP induced vasorelaxation in swine.

Conclusions: These findings suggest that a HE gestational diet can play a critical role in the development of offspring's vascular function, predisposing them to endothelial dysfunction. This dysfunction may lead to atherosclerotic disease development later in life.

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Related in: MedlinePlus

Endothelium-dependent (A) and endothelium-independent (B) relaxation responses to increasing doses of BK and SNP in the femoral artery of offspring exposed to gestational NE or HE diets and post-weaning NE or HE diets, at three months of age. (†) Significantly different (p < 0.05) from HE/NE group (‡) significantly different (p < 0.05) from HE/HE group (*) Main effect (p < 0.05).
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Fig1: Endothelium-dependent (A) and endothelium-independent (B) relaxation responses to increasing doses of BK and SNP in the femoral artery of offspring exposed to gestational NE or HE diets and post-weaning NE or HE diets, at three months of age. (†) Significantly different (p < 0.05) from HE/NE group (‡) significantly different (p < 0.05) from HE/HE group (*) Main effect (p < 0.05).

Mentions: There was a significant interaction between gestational and post-weaning diets for both BK and SNP induced vasorelaxation in the offspring (Figure 1A and B). Specifically, post hoc analysis revealed that the BK and SNP induced relaxation was significantly less in the HE/NE group compared to the NE/NE and the NE/HE groups. The SNP relaxation response for the HE/NE group was also significantly reduced compared to HE/HE, NE/NE, and NE/HE groups.Figure 1


Impact of excess gestational and post-weaning energy intake on vascular function of swine offspring.

Taheripour P, DeFord MA, Arentson-Lantz EJ, Donkin SS, Ajuwon KM, Newcomer SC - BMC Pregnancy Childbirth (2014)

Endothelium-dependent (A) and endothelium-independent (B) relaxation responses to increasing doses of BK and SNP in the femoral artery of offspring exposed to gestational NE or HE diets and post-weaning NE or HE diets, at three months of age. (†) Significantly different (p < 0.05) from HE/NE group (‡) significantly different (p < 0.05) from HE/HE group (*) Main effect (p < 0.05).
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4269172&req=5

Fig1: Endothelium-dependent (A) and endothelium-independent (B) relaxation responses to increasing doses of BK and SNP in the femoral artery of offspring exposed to gestational NE or HE diets and post-weaning NE or HE diets, at three months of age. (†) Significantly different (p < 0.05) from HE/NE group (‡) significantly different (p < 0.05) from HE/HE group (*) Main effect (p < 0.05).
Mentions: There was a significant interaction between gestational and post-weaning diets for both BK and SNP induced vasorelaxation in the offspring (Figure 1A and B). Specifically, post hoc analysis revealed that the BK and SNP induced relaxation was significantly less in the HE/NE group compared to the NE/NE and the NE/HE groups. The SNP relaxation response for the HE/NE group was also significantly reduced compared to HE/HE, NE/NE, and NE/HE groups.Figure 1

Bottom Line: Endothelial-dependent and -independent vasorelaxation was measured utilizing wire-myography and increasing concentrations of bradykinin (BK) and sodium nitroprusside (SNP), respectively.BK and SNP induced vasorelaxation were significantly reduced in the femoral arteries of gestational HE offspring.This dysfunction may lead to atherosclerotic disease development later in life.

View Article: PubMed Central - PubMed

Affiliation: Department of Health and Kinesiology, Purdue University, 3705 Chancellor Way, West Lafayette 47906, IN, USA. pardisd2@gmail.com.

ABSTRACT

Background: The development of long-term vascular disease can be linked to the intrauterine environment, and maternal nutrition during gestation plays a critical role in the future vascular health of offspring. The purpose of this investigation was to test the hypothesis that a high-energy (HE) gestational diet, HE post-weaning diet, or their combination will lead to endothelial dysfunction in offspring.

Methods: Duroc × Landrace gilts (n = 16) were assigned to either a HE (10,144 Kcal/day, n = 8) or normal energy (NE: 6721 Kcal/day, n = 8) diet throughout pregnancy. Piglets were placed on either a NE or HE diet during the growth phase. At 3 months of age femoral arteries were harvested from offspring (n = 47). Endothelial-dependent and -independent vasorelaxation was measured utilizing wire-myography and increasing concentrations of bradykinin (BK) and sodium nitroprusside (SNP), respectively.

Results: BK and SNP induced vasorelaxation were significantly reduced in the femoral arteries of gestational HE offspring. However, no effect for the post-weaning diet on BK and SNP induced vasorelaxation was seen. This investigation demonstrates that a HE diet prenatally diminishes both BK and SNP induced vasorelaxation in swine.

Conclusions: These findings suggest that a HE gestational diet can play a critical role in the development of offspring's vascular function, predisposing them to endothelial dysfunction. This dysfunction may lead to atherosclerotic disease development later in life.

Show MeSH
Related in: MedlinePlus