Limits...
Risk factors associated with serum levels of the inflammatory biomarker soluble urokinase plasminogen activator receptor in a general population.

Haupt TH, Kallemose T, Ladelund S, Rasmussen LJ, Thorball CW, Andersen O, Pisinger C, Eugen-Olsen J - Biomark Insights (2014)

Bottom Line: An unhealthy diet and alcohol abstinence in men were also associated with higher suPAR levels.In conclusion, smoking and morbid obesity were strongly associated with higher serum suPAR levels in this general population.Lifestyle changes are likely to affect suPAR since ex-smokers had suPAR levels comparable to those of never-smokers.

View Article: PubMed Central - PubMed

Affiliation: Clinical Research Centre, Department 056, Hvidovre Hospital, Hvidovre, Denmark.

ABSTRACT
The soluble urokinase plasminogen activator receptor (suPAR) is a biomarker of mortality risk in various patient populations. However, little is known about the implications of lifestyle for suPAR levels in the general population. Lifestyle, demographic, and cardiovascular disease (CVD) risk factor data were collected from 5,538 participants in the Danish population-based Inter99 study. Their suPAR levels were measured using a sandwich enzyme-linked immunosorbent assay. In the final adjusted model, smoking and morbid obesity were strongly associated with higher suPAR levels (P < 0.001). An unhealthy diet and alcohol abstinence in men were also associated with higher suPAR levels. Physical activity in leisure time had a modest impact on suPAR levels in univariate analysis, but not in the final adjusted model. In conclusion, smoking and morbid obesity were strongly associated with higher serum suPAR levels in this general population. Diet and alcohol consumption also seemed to impact suPAR levels. Lifestyle changes are likely to affect suPAR since ex-smokers had suPAR levels comparable to those of never-smokers.

No MeSH data available.


Related in: MedlinePlus

The average suPAR levels in the six illustration persons according to the Combined model. The two healthy persons are equivalent to the reference point in the model (30 years old and healthy). The pair with high CVD risk instead had a total cholesterol level of 8 mmol/L, HDL cholesterol of 0.8 mmol/L, a triglyceride level of 6 mmol/L, a BMI of 40 kg/m2, incident diabetes, as well as both a personal and family history of MI. The CVD risk + heavy smoking pair also had a daily tobacco use of ≥25 g/day.
© Copyright Policy - open-access
Related In: Results  -  Collection


getmorefigures.php?uid=PMC4269129&req=5

f3-bmi-9-2014-091: The average suPAR levels in the six illustration persons according to the Combined model. The two healthy persons are equivalent to the reference point in the model (30 years old and healthy). The pair with high CVD risk instead had a total cholesterol level of 8 mmol/L, HDL cholesterol of 0.8 mmol/L, a triglyceride level of 6 mmol/L, a BMI of 40 kg/m2, incident diabetes, as well as both a personal and family history of MI. The CVD risk + heavy smoking pair also had a daily tobacco use of ≥25 g/day.

Mentions: To illustrate the combined effect of several risk factors on suPAR, we calculated the suPAR level for six illustration persons based on the Combined model (Fig. 3): two healthy, two with high risk of CVD (but no smoking), and two with high CVD risk including heavy daily smoking. A man with high CVD risk had 1.27 ng/mL higher suPAR, and a woman with high CVD risk had 1.74 ng/mL higher suPAR compared to their healthy counterparts. If heavy smoking was also present, this difference was 2.90 ng/mL and 3.31 ng/mL for men and women, respectively.


Risk factors associated with serum levels of the inflammatory biomarker soluble urokinase plasminogen activator receptor in a general population.

Haupt TH, Kallemose T, Ladelund S, Rasmussen LJ, Thorball CW, Andersen O, Pisinger C, Eugen-Olsen J - Biomark Insights (2014)

The average suPAR levels in the six illustration persons according to the Combined model. The two healthy persons are equivalent to the reference point in the model (30 years old and healthy). The pair with high CVD risk instead had a total cholesterol level of 8 mmol/L, HDL cholesterol of 0.8 mmol/L, a triglyceride level of 6 mmol/L, a BMI of 40 kg/m2, incident diabetes, as well as both a personal and family history of MI. The CVD risk + heavy smoking pair also had a daily tobacco use of ≥25 g/day.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4269129&req=5

f3-bmi-9-2014-091: The average suPAR levels in the six illustration persons according to the Combined model. The two healthy persons are equivalent to the reference point in the model (30 years old and healthy). The pair with high CVD risk instead had a total cholesterol level of 8 mmol/L, HDL cholesterol of 0.8 mmol/L, a triglyceride level of 6 mmol/L, a BMI of 40 kg/m2, incident diabetes, as well as both a personal and family history of MI. The CVD risk + heavy smoking pair also had a daily tobacco use of ≥25 g/day.
Mentions: To illustrate the combined effect of several risk factors on suPAR, we calculated the suPAR level for six illustration persons based on the Combined model (Fig. 3): two healthy, two with high risk of CVD (but no smoking), and two with high CVD risk including heavy daily smoking. A man with high CVD risk had 1.27 ng/mL higher suPAR, and a woman with high CVD risk had 1.74 ng/mL higher suPAR compared to their healthy counterparts. If heavy smoking was also present, this difference was 2.90 ng/mL and 3.31 ng/mL for men and women, respectively.

Bottom Line: An unhealthy diet and alcohol abstinence in men were also associated with higher suPAR levels.In conclusion, smoking and morbid obesity were strongly associated with higher serum suPAR levels in this general population.Lifestyle changes are likely to affect suPAR since ex-smokers had suPAR levels comparable to those of never-smokers.

View Article: PubMed Central - PubMed

Affiliation: Clinical Research Centre, Department 056, Hvidovre Hospital, Hvidovre, Denmark.

ABSTRACT
The soluble urokinase plasminogen activator receptor (suPAR) is a biomarker of mortality risk in various patient populations. However, little is known about the implications of lifestyle for suPAR levels in the general population. Lifestyle, demographic, and cardiovascular disease (CVD) risk factor data were collected from 5,538 participants in the Danish population-based Inter99 study. Their suPAR levels were measured using a sandwich enzyme-linked immunosorbent assay. In the final adjusted model, smoking and morbid obesity were strongly associated with higher suPAR levels (P < 0.001). An unhealthy diet and alcohol abstinence in men were also associated with higher suPAR levels. Physical activity in leisure time had a modest impact on suPAR levels in univariate analysis, but not in the final adjusted model. In conclusion, smoking and morbid obesity were strongly associated with higher serum suPAR levels in this general population. Diet and alcohol consumption also seemed to impact suPAR levels. Lifestyle changes are likely to affect suPAR since ex-smokers had suPAR levels comparable to those of never-smokers.

No MeSH data available.


Related in: MedlinePlus