Limits...
Risk factors associated with serum levels of the inflammatory biomarker soluble urokinase plasminogen activator receptor in a general population.

Haupt TH, Kallemose T, Ladelund S, Rasmussen LJ, Thorball CW, Andersen O, Pisinger C, Eugen-Olsen J - Biomark Insights (2014)

Bottom Line: An unhealthy diet and alcohol abstinence in men were also associated with higher suPAR levels.In conclusion, smoking and morbid obesity were strongly associated with higher serum suPAR levels in this general population.Lifestyle changes are likely to affect suPAR since ex-smokers had suPAR levels comparable to those of never-smokers.

View Article: PubMed Central - PubMed

Affiliation: Clinical Research Centre, Department 056, Hvidovre Hospital, Hvidovre, Denmark.

ABSTRACT
The soluble urokinase plasminogen activator receptor (suPAR) is a biomarker of mortality risk in various patient populations. However, little is known about the implications of lifestyle for suPAR levels in the general population. Lifestyle, demographic, and cardiovascular disease (CVD) risk factor data were collected from 5,538 participants in the Danish population-based Inter99 study. Their suPAR levels were measured using a sandwich enzyme-linked immunosorbent assay. In the final adjusted model, smoking and morbid obesity were strongly associated with higher suPAR levels (P < 0.001). An unhealthy diet and alcohol abstinence in men were also associated with higher suPAR levels. Physical activity in leisure time had a modest impact on suPAR levels in univariate analysis, but not in the final adjusted model. In conclusion, smoking and morbid obesity were strongly associated with higher serum suPAR levels in this general population. Diet and alcohol consumption also seemed to impact suPAR levels. Lifestyle changes are likely to affect suPAR since ex-smokers had suPAR levels comparable to those of never-smokers.

No MeSH data available.


Related in: MedlinePlus

The association between BMI and serum suPAR levels for men (A) and women (B) in the Combined model with 95% CIs (dotted lines).
© Copyright Policy - open-access
Related In: Results  -  Collection


getmorefigures.php?uid=PMC4269129&req=5

f1-bmi-9-2014-091: The association between BMI and serum suPAR levels for men (A) and women (B) in the Combined model with 95% CIs (dotted lines).

Mentions: Triglycerides, SBP, and a family history of MI had no effect on suPAR level in the CVD model. Total cholesterol was associated with lower suPAR levels in men and higher suPAR levels in women. However, the associations were weak (P < 0.05). In contrast, HDL cholesterol was strongly associated with lower suPAR levels (P < 0.001) in both the CVD and Combined models. A personal history of MI was associated with higher suPAR levels in both the CVD (P < 0.001) and Combined models, although the association was not as strong in the Combined model (P < 0.05). BMI was strongly associated with higher suPAR levels (P < 0.001 for both sexes, Fig. 1). Incident diabetes was moderately associated with higher suPAR levels in the CVD model (P < 0.01), but this was not statistically significant in the Combined model.


Risk factors associated with serum levels of the inflammatory biomarker soluble urokinase plasminogen activator receptor in a general population.

Haupt TH, Kallemose T, Ladelund S, Rasmussen LJ, Thorball CW, Andersen O, Pisinger C, Eugen-Olsen J - Biomark Insights (2014)

The association between BMI and serum suPAR levels for men (A) and women (B) in the Combined model with 95% CIs (dotted lines).
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4269129&req=5

f1-bmi-9-2014-091: The association between BMI and serum suPAR levels for men (A) and women (B) in the Combined model with 95% CIs (dotted lines).
Mentions: Triglycerides, SBP, and a family history of MI had no effect on suPAR level in the CVD model. Total cholesterol was associated with lower suPAR levels in men and higher suPAR levels in women. However, the associations were weak (P < 0.05). In contrast, HDL cholesterol was strongly associated with lower suPAR levels (P < 0.001) in both the CVD and Combined models. A personal history of MI was associated with higher suPAR levels in both the CVD (P < 0.001) and Combined models, although the association was not as strong in the Combined model (P < 0.05). BMI was strongly associated with higher suPAR levels (P < 0.001 for both sexes, Fig. 1). Incident diabetes was moderately associated with higher suPAR levels in the CVD model (P < 0.01), but this was not statistically significant in the Combined model.

Bottom Line: An unhealthy diet and alcohol abstinence in men were also associated with higher suPAR levels.In conclusion, smoking and morbid obesity were strongly associated with higher serum suPAR levels in this general population.Lifestyle changes are likely to affect suPAR since ex-smokers had suPAR levels comparable to those of never-smokers.

View Article: PubMed Central - PubMed

Affiliation: Clinical Research Centre, Department 056, Hvidovre Hospital, Hvidovre, Denmark.

ABSTRACT
The soluble urokinase plasminogen activator receptor (suPAR) is a biomarker of mortality risk in various patient populations. However, little is known about the implications of lifestyle for suPAR levels in the general population. Lifestyle, demographic, and cardiovascular disease (CVD) risk factor data were collected from 5,538 participants in the Danish population-based Inter99 study. Their suPAR levels were measured using a sandwich enzyme-linked immunosorbent assay. In the final adjusted model, smoking and morbid obesity were strongly associated with higher suPAR levels (P < 0.001). An unhealthy diet and alcohol abstinence in men were also associated with higher suPAR levels. Physical activity in leisure time had a modest impact on suPAR levels in univariate analysis, but not in the final adjusted model. In conclusion, smoking and morbid obesity were strongly associated with higher serum suPAR levels in this general population. Diet and alcohol consumption also seemed to impact suPAR levels. Lifestyle changes are likely to affect suPAR since ex-smokers had suPAR levels comparable to those of never-smokers.

No MeSH data available.


Related in: MedlinePlus