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Macular findings obtained by spectral domain optical coherence tomography in retinopathy of prematurity.

Erol MK, Ozdemir O, Turgut Coban D, Bilgin AB, Dogan B, Sogutlu Sari E, Toslak D - J Ophthalmol (2014)

Bottom Line: Data regarding central foveal thickness (CFT), cystoid macular edema (CME), and cyst grading were compared.A significantly greater percentage of eyes with ROP were found to have CME (54%) compared to eyes without ROP (31%; P = 0.001).Conclusions.

View Article: PubMed Central - PubMed

Affiliation: Department of Ophthalmology, Antalya Training and Research Hospital, 07030 Antalya, Turkey.

ABSTRACT
Purpose. To examine the macular findings obtained with spectral domain optical coherence tomography (SD OCT) in infants with retinopathy of prematurity (ROP). Materials and Methods. The macular SD OCT images of 190 premature infants were analyzed. Data regarding central foveal thickness (CFT), cystoid macular edema (CME), and cyst grading were compared. The relationships of CFT with gestational age and birth weight were investigated. Results. The results were obtained from 358 eyes of 179 infants (81 females and 98 males) of a mean gestational age of 30.9 ± 2.7 weeks and a mean birth weight of 1609 ± 477 g. ROP was diagnosed in 126 eyes and CME in 139 eyes. A significantly greater percentage of eyes with ROP were found to have CME (54%) compared to eyes without ROP (31%; P = 0.001). The incidence of CME was 46.3% for stage 1 ROP, 57.1% for stage 2, and 87.5% for stage 3. There was a weakly inverse correlation between CFT, gestational age, and birth weight (P = 0.025, r = -0.227; P = 0.002, r = -0.182, resp., Spearman correlation test). Conclusions. High-quality SD OCT images can be obtained from premature infants using the iVue system. Severity and frequency of CME in premature infants increase as stage of ROP increases.

No MeSH data available.


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(a) OCT image of a patient with cystoid macular edema at 39-week postmenstrual age and (b) after resolution of cystoid macular edema six weeks later.
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fig4: (a) OCT image of a patient with cystoid macular edema at 39-week postmenstrual age and (b) after resolution of cystoid macular edema six weeks later.

Mentions: At a mean postmenstrual age of 44.2 ± 3.5 weeks, regression of cystoid macular edema was observed in 71 eyes (Figure 4). Intravitreal ranibizumab injection was administered to five infants for treatment of Type 1 ROP at a mean postmenstrual age of 36.2 ± 1.9 weeks. CFT increased in three infants and did not increase in two infants within one week after intravitreal ranibizumab treatment (Figure 5). Of the two infants in whom CFT did not increase, cystoid macular edema resolved in one infant two months after intravitreal ranibizumab injection (Figure 6). At the mean 38.2 ± 3.9 weeks of postmenstrual age, there was a weakly inverse correlation between CFT and gestational age (P = 0.025, r = −0.227) (Figure 7) and between CFT and birth weight (P = 0.002, r = −0.182) (Figure 8).


Macular findings obtained by spectral domain optical coherence tomography in retinopathy of prematurity.

Erol MK, Ozdemir O, Turgut Coban D, Bilgin AB, Dogan B, Sogutlu Sari E, Toslak D - J Ophthalmol (2014)

(a) OCT image of a patient with cystoid macular edema at 39-week postmenstrual age and (b) after resolution of cystoid macular edema six weeks later.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4269090&req=5

fig4: (a) OCT image of a patient with cystoid macular edema at 39-week postmenstrual age and (b) after resolution of cystoid macular edema six weeks later.
Mentions: At a mean postmenstrual age of 44.2 ± 3.5 weeks, regression of cystoid macular edema was observed in 71 eyes (Figure 4). Intravitreal ranibizumab injection was administered to five infants for treatment of Type 1 ROP at a mean postmenstrual age of 36.2 ± 1.9 weeks. CFT increased in three infants and did not increase in two infants within one week after intravitreal ranibizumab treatment (Figure 5). Of the two infants in whom CFT did not increase, cystoid macular edema resolved in one infant two months after intravitreal ranibizumab injection (Figure 6). At the mean 38.2 ± 3.9 weeks of postmenstrual age, there was a weakly inverse correlation between CFT and gestational age (P = 0.025, r = −0.227) (Figure 7) and between CFT and birth weight (P = 0.002, r = −0.182) (Figure 8).

Bottom Line: Data regarding central foveal thickness (CFT), cystoid macular edema (CME), and cyst grading were compared.A significantly greater percentage of eyes with ROP were found to have CME (54%) compared to eyes without ROP (31%; P = 0.001).Conclusions.

View Article: PubMed Central - PubMed

Affiliation: Department of Ophthalmology, Antalya Training and Research Hospital, 07030 Antalya, Turkey.

ABSTRACT
Purpose. To examine the macular findings obtained with spectral domain optical coherence tomography (SD OCT) in infants with retinopathy of prematurity (ROP). Materials and Methods. The macular SD OCT images of 190 premature infants were analyzed. Data regarding central foveal thickness (CFT), cystoid macular edema (CME), and cyst grading were compared. The relationships of CFT with gestational age and birth weight were investigated. Results. The results were obtained from 358 eyes of 179 infants (81 females and 98 males) of a mean gestational age of 30.9 ± 2.7 weeks and a mean birth weight of 1609 ± 477 g. ROP was diagnosed in 126 eyes and CME in 139 eyes. A significantly greater percentage of eyes with ROP were found to have CME (54%) compared to eyes without ROP (31%; P = 0.001). The incidence of CME was 46.3% for stage 1 ROP, 57.1% for stage 2, and 87.5% for stage 3. There was a weakly inverse correlation between CFT, gestational age, and birth weight (P = 0.025, r = -0.227; P = 0.002, r = -0.182, resp., Spearman correlation test). Conclusions. High-quality SD OCT images can be obtained from premature infants using the iVue system. Severity and frequency of CME in premature infants increase as stage of ROP increases.

No MeSH data available.


Related in: MedlinePlus