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Macular findings obtained by spectral domain optical coherence tomography in retinopathy of prematurity.

Erol MK, Ozdemir O, Turgut Coban D, Bilgin AB, Dogan B, Sogutlu Sari E, Toslak D - J Ophthalmol (2014)

Bottom Line: Data regarding central foveal thickness (CFT), cystoid macular edema (CME), and cyst grading were compared.A significantly greater percentage of eyes with ROP were found to have CME (54%) compared to eyes without ROP (31%; P = 0.001).Conclusions.

View Article: PubMed Central - PubMed

Affiliation: Department of Ophthalmology, Antalya Training and Research Hospital, 07030 Antalya, Turkey.

ABSTRACT
Purpose. To examine the macular findings obtained with spectral domain optical coherence tomography (SD OCT) in infants with retinopathy of prematurity (ROP). Materials and Methods. The macular SD OCT images of 190 premature infants were analyzed. Data regarding central foveal thickness (CFT), cystoid macular edema (CME), and cyst grading were compared. The relationships of CFT with gestational age and birth weight were investigated. Results. The results were obtained from 358 eyes of 179 infants (81 females and 98 males) of a mean gestational age of 30.9 ± 2.7 weeks and a mean birth weight of 1609 ± 477 g. ROP was diagnosed in 126 eyes and CME in 139 eyes. A significantly greater percentage of eyes with ROP were found to have CME (54%) compared to eyes without ROP (31%; P = 0.001). The incidence of CME was 46.3% for stage 1 ROP, 57.1% for stage 2, and 87.5% for stage 3. There was a weakly inverse correlation between CFT, gestational age, and birth weight (P = 0.025, r = -0.227; P = 0.002, r = -0.182, resp., Spearman correlation test). Conclusions. High-quality SD OCT images can be obtained from premature infants using the iVue system. Severity and frequency of CME in premature infants increase as stage of ROP increases.

No MeSH data available.


Related in: MedlinePlus

Comparisons of mean central foveal thickness (CFT) between the eyes with and without ROP. (ROP: retinopathy of prematurity, SD: standard deviation, and P: 0.001, Mann-Whitney U test).
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fig2: Comparisons of mean central foveal thickness (CFT) between the eyes with and without ROP. (ROP: retinopathy of prematurity, SD: standard deviation, and P: 0.001, Mann-Whitney U test).

Mentions: Figure 2 shows the results of comparison of mean CFT between the eyes with and without ROP. The mean CFT of all eyes was 175.2 ± 106.5 μm, while that of eyes without ROP was 163.3 ± 105.3 and that of eyes with ROP was 199.8 ± 97.3 μm (stage 1: 192.2 ± 102.5 μm, stage 2: 192.4 ± 70.7 μm, and stage 3: 239.3 ± 69.7 μm). The mean CFT was found to be significantly larger in eyes with ROP than eyes without ROP (P = 0.001, Mann-Whitney U test). Analysis of cyst grading based on OCT scanning revealed a significant difference between classifications of ROP stage, with cyst grade found to increase with increasing ROP stage (Figure 3).


Macular findings obtained by spectral domain optical coherence tomography in retinopathy of prematurity.

Erol MK, Ozdemir O, Turgut Coban D, Bilgin AB, Dogan B, Sogutlu Sari E, Toslak D - J Ophthalmol (2014)

Comparisons of mean central foveal thickness (CFT) between the eyes with and without ROP. (ROP: retinopathy of prematurity, SD: standard deviation, and P: 0.001, Mann-Whitney U test).
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4269090&req=5

fig2: Comparisons of mean central foveal thickness (CFT) between the eyes with and without ROP. (ROP: retinopathy of prematurity, SD: standard deviation, and P: 0.001, Mann-Whitney U test).
Mentions: Figure 2 shows the results of comparison of mean CFT between the eyes with and without ROP. The mean CFT of all eyes was 175.2 ± 106.5 μm, while that of eyes without ROP was 163.3 ± 105.3 and that of eyes with ROP was 199.8 ± 97.3 μm (stage 1: 192.2 ± 102.5 μm, stage 2: 192.4 ± 70.7 μm, and stage 3: 239.3 ± 69.7 μm). The mean CFT was found to be significantly larger in eyes with ROP than eyes without ROP (P = 0.001, Mann-Whitney U test). Analysis of cyst grading based on OCT scanning revealed a significant difference between classifications of ROP stage, with cyst grade found to increase with increasing ROP stage (Figure 3).

Bottom Line: Data regarding central foveal thickness (CFT), cystoid macular edema (CME), and cyst grading were compared.A significantly greater percentage of eyes with ROP were found to have CME (54%) compared to eyes without ROP (31%; P = 0.001).Conclusions.

View Article: PubMed Central - PubMed

Affiliation: Department of Ophthalmology, Antalya Training and Research Hospital, 07030 Antalya, Turkey.

ABSTRACT
Purpose. To examine the macular findings obtained with spectral domain optical coherence tomography (SD OCT) in infants with retinopathy of prematurity (ROP). Materials and Methods. The macular SD OCT images of 190 premature infants were analyzed. Data regarding central foveal thickness (CFT), cystoid macular edema (CME), and cyst grading were compared. The relationships of CFT with gestational age and birth weight were investigated. Results. The results were obtained from 358 eyes of 179 infants (81 females and 98 males) of a mean gestational age of 30.9 ± 2.7 weeks and a mean birth weight of 1609 ± 477 g. ROP was diagnosed in 126 eyes and CME in 139 eyes. A significantly greater percentage of eyes with ROP were found to have CME (54%) compared to eyes without ROP (31%; P = 0.001). The incidence of CME was 46.3% for stage 1 ROP, 57.1% for stage 2, and 87.5% for stage 3. There was a weakly inverse correlation between CFT, gestational age, and birth weight (P = 0.025, r = -0.227; P = 0.002, r = -0.182, resp., Spearman correlation test). Conclusions. High-quality SD OCT images can be obtained from premature infants using the iVue system. Severity and frequency of CME in premature infants increase as stage of ROP increases.

No MeSH data available.


Related in: MedlinePlus