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Effects of varying duty cycle and pulse width on high-intensity focused ultrasound (HIFU)-induced transcranial thrombolysis.

Hölscher T, Raman R, Fisher DJ, Ahadi G, Zadicario E, Voie A - J Ther Ultrasound (2013)

Bottom Line: Four different duty cycles were tested against four different pulse widths.For all study groups, an increase in thrombolysis efficacy could be seen in association with increasing DC and/or PW (p < 0.0001).Using transcranial HIFU, significant thrombolysis can be achieved within seconds and without the use of lytic drugs in vitro.

View Article: PubMed Central - HTML - PubMed

Affiliation: Brain Ultrasound Research Laboratory (BURL), Department of Radiology, University of California San Diego, San Diego, CA, 92103, USA ; Department of Neurosciences, University of California San Diego, 200 West Arbor Drive, San Diego, CA, 92103-8756, USA.

ABSTRACT
The goal was to test the effects of various combinations of pulse widths (PW) and duty cycles (DC) on high-intensity focused ultrasound (HIFU)-induced sonothrombolysis efficacy using an in vitro flow model. An ExAblate™ 4000 HIFU headsystem (InSightec, Inc., Israel) was used. Artificial blood clots were placed into test tubes inside a human calvarium and exposed to pulsatile flow. Four different duty cycles were tested against four different pulse widths. For all study groups, an increase in thrombolysis efficacy could be seen in association with increasing DC and/or PW (p < 0.0001). Using transcranial HIFU, significant thrombolysis can be achieved within seconds and without the use of lytic drugs in vitro. Longer duty cycles in combination with longer pulse widths seem to have the highest potential to optimize clot lysis efficacy.

No MeSH data available.


Related in: MedlinePlus

Histogram showing the percent clot weight loss for all 16 study groups. 5% DC (red bars), 10% DC (green bars), 20% DC (yellow bars), and 50% DC (blue bars).
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Figure 3: Histogram showing the percent clot weight loss for all 16 study groups. 5% DC (red bars), 10% DC (green bars), 20% DC (yellow bars), and 50% DC (blue bars).

Mentions: A visual presentation of the percent weight loss for each group, displayed as boxplots, is given in Figure 3.


Effects of varying duty cycle and pulse width on high-intensity focused ultrasound (HIFU)-induced transcranial thrombolysis.

Hölscher T, Raman R, Fisher DJ, Ahadi G, Zadicario E, Voie A - J Ther Ultrasound (2013)

Histogram showing the percent clot weight loss for all 16 study groups. 5% DC (red bars), 10% DC (green bars), 20% DC (yellow bars), and 50% DC (blue bars).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4265951&req=5

Figure 3: Histogram showing the percent clot weight loss for all 16 study groups. 5% DC (red bars), 10% DC (green bars), 20% DC (yellow bars), and 50% DC (blue bars).
Mentions: A visual presentation of the percent weight loss for each group, displayed as boxplots, is given in Figure 3.

Bottom Line: Four different duty cycles were tested against four different pulse widths.For all study groups, an increase in thrombolysis efficacy could be seen in association with increasing DC and/or PW (p < 0.0001).Using transcranial HIFU, significant thrombolysis can be achieved within seconds and without the use of lytic drugs in vitro.

View Article: PubMed Central - HTML - PubMed

Affiliation: Brain Ultrasound Research Laboratory (BURL), Department of Radiology, University of California San Diego, San Diego, CA, 92103, USA ; Department of Neurosciences, University of California San Diego, 200 West Arbor Drive, San Diego, CA, 92103-8756, USA.

ABSTRACT
The goal was to test the effects of various combinations of pulse widths (PW) and duty cycles (DC) on high-intensity focused ultrasound (HIFU)-induced sonothrombolysis efficacy using an in vitro flow model. An ExAblate™ 4000 HIFU headsystem (InSightec, Inc., Israel) was used. Artificial blood clots were placed into test tubes inside a human calvarium and exposed to pulsatile flow. Four different duty cycles were tested against four different pulse widths. For all study groups, an increase in thrombolysis efficacy could be seen in association with increasing DC and/or PW (p < 0.0001). Using transcranial HIFU, significant thrombolysis can be achieved within seconds and without the use of lytic drugs in vitro. Longer duty cycles in combination with longer pulse widths seem to have the highest potential to optimize clot lysis efficacy.

No MeSH data available.


Related in: MedlinePlus