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Atrazine and pregnancy outcomes: a systematic review of epidemiologic evidence.

Goodman M, Mandel JS, DeSesso JM, Scialli AR - Birth Defects Res. B Dev. Reprod. Toxicol. (2014)

Bottom Line: As a quantitative meta-analysis was not feasible, the study results were categorized qualitatively as positive, , or mixed.Without good quality data, the results are difficult to assess; however, it is worth noting that none of the outcome categories demonstrated consistent positive associations across studies.Considering the poor quality of the data and the lack of robust findings across studies, conclusions about a causal link between ATR and adverse pregnancy outcomes are not warranted.

View Article: PubMed Central - PubMed

Affiliation: Emory University School of Public Health, Atlanta, Georgia.

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Related in: MedlinePlus

Overview of study findings on the associations between ATR/triazine herbicide (or surrogate) exposures and birth defects.
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fig01: Overview of study findings on the associations between ATR/triazine herbicide (or surrogate) exposures and birth defects.

Mentions: As shown in Figure 1, few studies examined the same or similar outcomes. The most commonly addressed endpoints were all congenital malformations combined (five studies), abdominal abnormalities (six studies), and urogenital defects (six studies). None of these three outcome categories demonstrated consistent positive associations across studies. For other types of birth defects an assessment of consistency is difficult due to the few observations. Figure 1 also shows that most positive results (7 of 10) were reported in studies that used aggregate data to characterize both the exposure and outcome (Tier 3). In contrast, most associations in studies of individual-level data (Tier 1) were consistent with the hypothesis.


Atrazine and pregnancy outcomes: a systematic review of epidemiologic evidence.

Goodman M, Mandel JS, DeSesso JM, Scialli AR - Birth Defects Res. B Dev. Reprod. Toxicol. (2014)

Overview of study findings on the associations between ATR/triazine herbicide (or surrogate) exposures and birth defects.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4265844&req=5

fig01: Overview of study findings on the associations between ATR/triazine herbicide (or surrogate) exposures and birth defects.
Mentions: As shown in Figure 1, few studies examined the same or similar outcomes. The most commonly addressed endpoints were all congenital malformations combined (five studies), abdominal abnormalities (six studies), and urogenital defects (six studies). None of these three outcome categories demonstrated consistent positive associations across studies. For other types of birth defects an assessment of consistency is difficult due to the few observations. Figure 1 also shows that most positive results (7 of 10) were reported in studies that used aggregate data to characterize both the exposure and outcome (Tier 3). In contrast, most associations in studies of individual-level data (Tier 1) were consistent with the hypothesis.

Bottom Line: As a quantitative meta-analysis was not feasible, the study results were categorized qualitatively as positive, , or mixed.Without good quality data, the results are difficult to assess; however, it is worth noting that none of the outcome categories demonstrated consistent positive associations across studies.Considering the poor quality of the data and the lack of robust findings across studies, conclusions about a causal link between ATR and adverse pregnancy outcomes are not warranted.

View Article: PubMed Central - PubMed

Affiliation: Emory University School of Public Health, Atlanta, Georgia.

Show MeSH
Related in: MedlinePlus