Limits...
Antimicrobial Resistance in Pseudomonas sp. Causing Infections in Trauma Patients: A 6 Year Experience from a South Asian Country.

Rajkumari N, John NV, Mathur P, Misra MC - J Glob Infect Dis (2014)

Bottom Line: The highest level of resistance was seen in tetracycline (2,166, 95.5%, P < 0.001) and chloramphenicol (2,160, 95.2%, P < 0.001) and least in meropenem (1,739, 76.7%, P < 0.003).Of the total, 1,692 (74.6%) isolates were MDR in which P. aeruginosa (75%) were maximum.Of 1,797 imipenem-resistant P. aeruginosa isolated during the study period, 1,763 (98%) showed resistance to ciprofloxacin or levofloxacin, suggesting that cross-resistance may have developed for imipenem due to prior use of fluoroquinolones.

View Article: PubMed Central - PubMed

Affiliation: Department of Laboratory Medicine, Microbiology Division, All India Institute of Medical Sciences, New Delhi, India.

ABSTRACT
Drug resistance to Pseudomonas sp. has spread to such a level irrespective of the type of patients, that its pattern of distribution and antibiotic resistance needs to be studied in detail, especially in trauma patients and hence the study. A 6 year study was carried out among trauma patients to see the trend and type of resistance prevalent in the apex hospital for trauma care in India among nonduplicate isolates where multidrug-resistance (MDR), cross-resistance and pan-drug resistance in Pseudomonas sp. were analyzed. Of the total 2,269 isolates obtained, the species, which was maximally isolated was Pseudomonas aeruginosa (2,224, 98%). The highest level of resistance was seen in tetracycline (2,166, 95.5%, P < 0.001) and chloramphenicol (2,160, 95.2%, P < 0.001) and least in meropenem (1,739, 76.7%, P < 0.003). Of the total, 1,692 (74.6%) isolates were MDR in which P. aeruginosa (75%) were maximum. MDR Pseudomonas is slowing increasing since the beginning of the study period. Of 1,797 imipenem-resistant P. aeruginosa isolated during the study period, 1,763 (98%) showed resistance to ciprofloxacin or levofloxacin, suggesting that cross-resistance may have developed for imipenem due to prior use of fluoroquinolones. Antibiotic resistance in Pseudomonas sp. is fast becoming a problem in trauma patients, especially in those who requires prolong hospital stay, which calls for proper antimicrobial stewardship.

No MeSH data available.


Related in: MedlinePlus

Monthly distribution of most commonly isolated Pseudomonas spp. along with multidrug-resistant (MDR) and non-MDR isolates
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4265834&req=5

Figure 1: Monthly distribution of most commonly isolated Pseudomonas spp. along with multidrug-resistant (MDR) and non-MDR isolates

Mentions: When we analyzed the distribution of MDR Pseudomonas [Figures 1 and 2] among the different species obtained during the study period, P. aeruginosa accounted for the maximum MDR isolates with a total number of 1,667 (75%), followed in decreasing frequency by P. putida (14, 56%), P. luteola (4,80%), P. flavescens (4, 80%), P. stutzeri (2, 25%) and P. alcaligenes (1). However, no MDR was isolated among the P. mandocina. A P = 0.005 was seen (χ2 = 18.51, degree of freedom = 6) and hence not significant.


Antimicrobial Resistance in Pseudomonas sp. Causing Infections in Trauma Patients: A 6 Year Experience from a South Asian Country.

Rajkumari N, John NV, Mathur P, Misra MC - J Glob Infect Dis (2014)

Monthly distribution of most commonly isolated Pseudomonas spp. along with multidrug-resistant (MDR) and non-MDR isolates
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4265834&req=5

Figure 1: Monthly distribution of most commonly isolated Pseudomonas spp. along with multidrug-resistant (MDR) and non-MDR isolates
Mentions: When we analyzed the distribution of MDR Pseudomonas [Figures 1 and 2] among the different species obtained during the study period, P. aeruginosa accounted for the maximum MDR isolates with a total number of 1,667 (75%), followed in decreasing frequency by P. putida (14, 56%), P. luteola (4,80%), P. flavescens (4, 80%), P. stutzeri (2, 25%) and P. alcaligenes (1). However, no MDR was isolated among the P. mandocina. A P = 0.005 was seen (χ2 = 18.51, degree of freedom = 6) and hence not significant.

Bottom Line: The highest level of resistance was seen in tetracycline (2,166, 95.5%, P < 0.001) and chloramphenicol (2,160, 95.2%, P < 0.001) and least in meropenem (1,739, 76.7%, P < 0.003).Of the total, 1,692 (74.6%) isolates were MDR in which P. aeruginosa (75%) were maximum.Of 1,797 imipenem-resistant P. aeruginosa isolated during the study period, 1,763 (98%) showed resistance to ciprofloxacin or levofloxacin, suggesting that cross-resistance may have developed for imipenem due to prior use of fluoroquinolones.

View Article: PubMed Central - PubMed

Affiliation: Department of Laboratory Medicine, Microbiology Division, All India Institute of Medical Sciences, New Delhi, India.

ABSTRACT
Drug resistance to Pseudomonas sp. has spread to such a level irrespective of the type of patients, that its pattern of distribution and antibiotic resistance needs to be studied in detail, especially in trauma patients and hence the study. A 6 year study was carried out among trauma patients to see the trend and type of resistance prevalent in the apex hospital for trauma care in India among nonduplicate isolates where multidrug-resistance (MDR), cross-resistance and pan-drug resistance in Pseudomonas sp. were analyzed. Of the total 2,269 isolates obtained, the species, which was maximally isolated was Pseudomonas aeruginosa (2,224, 98%). The highest level of resistance was seen in tetracycline (2,166, 95.5%, P < 0.001) and chloramphenicol (2,160, 95.2%, P < 0.001) and least in meropenem (1,739, 76.7%, P < 0.003). Of the total, 1,692 (74.6%) isolates were MDR in which P. aeruginosa (75%) were maximum. MDR Pseudomonas is slowing increasing since the beginning of the study period. Of 1,797 imipenem-resistant P. aeruginosa isolated during the study period, 1,763 (98%) showed resistance to ciprofloxacin or levofloxacin, suggesting that cross-resistance may have developed for imipenem due to prior use of fluoroquinolones. Antibiotic resistance in Pseudomonas sp. is fast becoming a problem in trauma patients, especially in those who requires prolong hospital stay, which calls for proper antimicrobial stewardship.

No MeSH data available.


Related in: MedlinePlus