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Overview of pediatric testicular tumors in Korea.

Chung JM, Lee SD - Korean J Urol (2014)

Bottom Line: Because overall about 75% of prepubertal testicular tumors are benign, a testis-sparing approach is becoming more common in children.Orchiectomy and observation with very selective use of chemotherapy has become the standard approach when a malignant tumor is identified.Retroperitoneal lymph node dissection and radiation therapy play very limited roles.

View Article: PubMed Central - PubMed

Affiliation: Department of Urology, Pusan National University School of Medicine, Yangsan, Korea.

ABSTRACT
Prepubertal testicular tumors are rare compared with postpubertal testicular tumors. The incidence of prepubertal testicular tumors peaks at 2 years of age, tapers off after 4 years of age, and then begins to rise again at puberty. Prepubertal and postpubertal testicular tumors show many differences, including the typical tumor histology, molecular biological differences, and the malignant potential of tumors at different ages. Pediatric testicular tumors are classified as benign or malignant on the basis of their clinical behavior and histologically are divided into germ cell and gonadal stromal (nongerm cell) tumors. Many histological and biological studies have further confirmed the distinct nature of prepubertal and postpubertal testicular tumors. These differences have led to various management strategies for prepubertal and postpubertal tumors. Because overall about 75% of prepubertal testicular tumors are benign, a testis-sparing approach is becoming more common in children. Orchiectomy and observation with very selective use of chemotherapy has become the standard approach when a malignant tumor is identified. Retroperitoneal lymph node dissection and radiation therapy play very limited roles.

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Number of cases of prepubertal testicular tumors in various age groups in Korea [8,9].
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Figure 1: Number of cases of prepubertal testicular tumors in various age groups in Korea [8,9].

Mentions: According to race, testicular tumors during infancy are more common in whites and are rarer in black and Asian children [11]. In Korea, two large-scale studies registered pediatric testicular tumors in 2004 and 2011, respectively [7,8]. The incidence rate of pediatric testicular tumors greatly decreases after 4 years of age. Compared with the data obtained from the United States (76% of tumors before 2 years of age and 20% between 2 and 4 years of age) [2], the incidence rate of pediatric testicular tumors before 4 years of age in Korea is slightly lower (Fig. 1). In infants and children older than 5 years of age, benign tumors are more common than yolk sac tumors. Pediatric testicular tumors occurred at all ages in both studies.


Overview of pediatric testicular tumors in Korea.

Chung JM, Lee SD - Korean J Urol (2014)

Number of cases of prepubertal testicular tumors in various age groups in Korea [8,9].
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4265712&req=5

Figure 1: Number of cases of prepubertal testicular tumors in various age groups in Korea [8,9].
Mentions: According to race, testicular tumors during infancy are more common in whites and are rarer in black and Asian children [11]. In Korea, two large-scale studies registered pediatric testicular tumors in 2004 and 2011, respectively [7,8]. The incidence rate of pediatric testicular tumors greatly decreases after 4 years of age. Compared with the data obtained from the United States (76% of tumors before 2 years of age and 20% between 2 and 4 years of age) [2], the incidence rate of pediatric testicular tumors before 4 years of age in Korea is slightly lower (Fig. 1). In infants and children older than 5 years of age, benign tumors are more common than yolk sac tumors. Pediatric testicular tumors occurred at all ages in both studies.

Bottom Line: Because overall about 75% of prepubertal testicular tumors are benign, a testis-sparing approach is becoming more common in children.Orchiectomy and observation with very selective use of chemotherapy has become the standard approach when a malignant tumor is identified.Retroperitoneal lymph node dissection and radiation therapy play very limited roles.

View Article: PubMed Central - PubMed

Affiliation: Department of Urology, Pusan National University School of Medicine, Yangsan, Korea.

ABSTRACT
Prepubertal testicular tumors are rare compared with postpubertal testicular tumors. The incidence of prepubertal testicular tumors peaks at 2 years of age, tapers off after 4 years of age, and then begins to rise again at puberty. Prepubertal and postpubertal testicular tumors show many differences, including the typical tumor histology, molecular biological differences, and the malignant potential of tumors at different ages. Pediatric testicular tumors are classified as benign or malignant on the basis of their clinical behavior and histologically are divided into germ cell and gonadal stromal (nongerm cell) tumors. Many histological and biological studies have further confirmed the distinct nature of prepubertal and postpubertal testicular tumors. These differences have led to various management strategies for prepubertal and postpubertal tumors. Because overall about 75% of prepubertal testicular tumors are benign, a testis-sparing approach is becoming more common in children. Orchiectomy and observation with very selective use of chemotherapy has become the standard approach when a malignant tumor is identified. Retroperitoneal lymph node dissection and radiation therapy play very limited roles.

Show MeSH
Related in: MedlinePlus