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Effectiveness and safety of s-1-based therapy compared with 5-Fluorouracil-based therapy for advanced colorectal cancer: a meta-analysis.

Ye J, Chen J, Ge L, Liu A, Zhou S - Gastroenterol Res Pract (2014)

Bottom Line: The statistically significant differences in the meta-analysis indicated less incidence of graded 3-4 neutropenia (OR = 0.49, 95% CI = 0.35-0.68) and nausea/vomit (OR = 0.41, 95% CI = 0.23-0.72) in the SBT group, and there was no statistically significant difference in the incidence of grade 3-4 anemia, thrombocytopenia, leucopenia, diarrhea, and treatment-related deaths between two groups.Conclusions.SBT had similar efficacy and better safety than FBT and was an attractive alternative to FBT for patients of ACRC, but further investigations in different populations would be needed to confirm it.

View Article: PubMed Central - PubMed

Affiliation: Department of Medical Oncology, The Cancer Institute, Affiliated Tumor Hospital of Guangxi Medical University, Nanning, Guangxi 530021, China.

ABSTRACT
Objectives. The aim of our study was to compare the efficacy and safety of S-1-based therapy (SBT) versus 5-fluorouracil-based therapy (FBT) for advanced colorectal cancer (ACRC). Methods. A meta-analysis of all eligible randomized controlled trials (RCTs) was performed using RevMan 5.1.0 software. Results. A total of 1625 patients from twelve RCTs including 820 patients in the SBT group and 805 patients in the FBT group were available for analysis. The meta-analysis of overall survival (hazards ratio HR = 0.94, 95% CI = 0.80-1.10), progression-free survival (HR = 1.03, 95% CI = 0.91-1.18), and overall response rate (odds ratio OR = 1.23, 95% CI = 1.00-1.53) showed no statistical significance between SBT group and FBT group. The statistically significant differences in the meta-analysis indicated less incidence of graded 3-4 neutropenia (OR = 0.49, 95% CI = 0.35-0.68) and nausea/vomit (OR = 0.41, 95% CI = 0.23-0.72) in the SBT group, and there was no statistically significant difference in the incidence of grade 3-4 anemia, thrombocytopenia, leucopenia, diarrhea, and treatment-related deaths between two groups. Conclusions. SBT had similar efficacy and better safety than FBT and was an attractive alternative to FBT for patients of ACRC, but further investigations in different populations would be needed to confirm it.

No MeSH data available.


Related in: MedlinePlus

Forest plot of odds ratio of overall response rate.
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Related In: Results  -  Collection


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fig7: Forest plot of odds ratio of overall response rate.

Mentions: All included studies provided the information on ORR [6–17]. As shown in Figure 7, the pooled OR of ORR in fixed-effect model was 1.23 (95% CI: 1.00–1.53) with little evidence of heterogeneity (P = 0.62, I2 = 0%), which indicated there was no significant difference between SBT group and FBT group. Eleven trials reported DCR data [6–8, 10–17], the meta-analysis of the pooled data demonstrated that DCR was not different between the two groups (OR = 1.37, 95% CI = 0.99–1.89), and there was no heterogeneity across the trials (P = 0.80, I2 = 0%) (Figure 8).


Effectiveness and safety of s-1-based therapy compared with 5-Fluorouracil-based therapy for advanced colorectal cancer: a meta-analysis.

Ye J, Chen J, Ge L, Liu A, Zhou S - Gastroenterol Res Pract (2014)

Forest plot of odds ratio of overall response rate.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4265705&req=5

fig7: Forest plot of odds ratio of overall response rate.
Mentions: All included studies provided the information on ORR [6–17]. As shown in Figure 7, the pooled OR of ORR in fixed-effect model was 1.23 (95% CI: 1.00–1.53) with little evidence of heterogeneity (P = 0.62, I2 = 0%), which indicated there was no significant difference between SBT group and FBT group. Eleven trials reported DCR data [6–8, 10–17], the meta-analysis of the pooled data demonstrated that DCR was not different between the two groups (OR = 1.37, 95% CI = 0.99–1.89), and there was no heterogeneity across the trials (P = 0.80, I2 = 0%) (Figure 8).

Bottom Line: The statistically significant differences in the meta-analysis indicated less incidence of graded 3-4 neutropenia (OR = 0.49, 95% CI = 0.35-0.68) and nausea/vomit (OR = 0.41, 95% CI = 0.23-0.72) in the SBT group, and there was no statistically significant difference in the incidence of grade 3-4 anemia, thrombocytopenia, leucopenia, diarrhea, and treatment-related deaths between two groups.Conclusions.SBT had similar efficacy and better safety than FBT and was an attractive alternative to FBT for patients of ACRC, but further investigations in different populations would be needed to confirm it.

View Article: PubMed Central - PubMed

Affiliation: Department of Medical Oncology, The Cancer Institute, Affiliated Tumor Hospital of Guangxi Medical University, Nanning, Guangxi 530021, China.

ABSTRACT
Objectives. The aim of our study was to compare the efficacy and safety of S-1-based therapy (SBT) versus 5-fluorouracil-based therapy (FBT) for advanced colorectal cancer (ACRC). Methods. A meta-analysis of all eligible randomized controlled trials (RCTs) was performed using RevMan 5.1.0 software. Results. A total of 1625 patients from twelve RCTs including 820 patients in the SBT group and 805 patients in the FBT group were available for analysis. The meta-analysis of overall survival (hazards ratio HR = 0.94, 95% CI = 0.80-1.10), progression-free survival (HR = 1.03, 95% CI = 0.91-1.18), and overall response rate (odds ratio OR = 1.23, 95% CI = 1.00-1.53) showed no statistical significance between SBT group and FBT group. The statistically significant differences in the meta-analysis indicated less incidence of graded 3-4 neutropenia (OR = 0.49, 95% CI = 0.35-0.68) and nausea/vomit (OR = 0.41, 95% CI = 0.23-0.72) in the SBT group, and there was no statistically significant difference in the incidence of grade 3-4 anemia, thrombocytopenia, leucopenia, diarrhea, and treatment-related deaths between two groups. Conclusions. SBT had similar efficacy and better safety than FBT and was an attractive alternative to FBT for patients of ACRC, but further investigations in different populations would be needed to confirm it.

No MeSH data available.


Related in: MedlinePlus