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Effectiveness and safety of s-1-based therapy compared with 5-Fluorouracil-based therapy for advanced colorectal cancer: a meta-analysis.

Ye J, Chen J, Ge L, Liu A, Zhou S - Gastroenterol Res Pract (2014)

Bottom Line: The statistically significant differences in the meta-analysis indicated less incidence of graded 3-4 neutropenia (OR = 0.49, 95% CI = 0.35-0.68) and nausea/vomit (OR = 0.41, 95% CI = 0.23-0.72) in the SBT group, and there was no statistically significant difference in the incidence of grade 3-4 anemia, thrombocytopenia, leucopenia, diarrhea, and treatment-related deaths between two groups.Conclusions.SBT had similar efficacy and better safety than FBT and was an attractive alternative to FBT for patients of ACRC, but further investigations in different populations would be needed to confirm it.

View Article: PubMed Central - PubMed

Affiliation: Department of Medical Oncology, The Cancer Institute, Affiliated Tumor Hospital of Guangxi Medical University, Nanning, Guangxi 530021, China.

ABSTRACT
Objectives. The aim of our study was to compare the efficacy and safety of S-1-based therapy (SBT) versus 5-fluorouracil-based therapy (FBT) for advanced colorectal cancer (ACRC). Methods. A meta-analysis of all eligible randomized controlled trials (RCTs) was performed using RevMan 5.1.0 software. Results. A total of 1625 patients from twelve RCTs including 820 patients in the SBT group and 805 patients in the FBT group were available for analysis. The meta-analysis of overall survival (hazards ratio HR = 0.94, 95% CI = 0.80-1.10), progression-free survival (HR = 1.03, 95% CI = 0.91-1.18), and overall response rate (odds ratio OR = 1.23, 95% CI = 1.00-1.53) showed no statistical significance between SBT group and FBT group. The statistically significant differences in the meta-analysis indicated less incidence of graded 3-4 neutropenia (OR = 0.49, 95% CI = 0.35-0.68) and nausea/vomit (OR = 0.41, 95% CI = 0.23-0.72) in the SBT group, and there was no statistically significant difference in the incidence of grade 3-4 anemia, thrombocytopenia, leucopenia, diarrhea, and treatment-related deaths between two groups. Conclusions. SBT had similar efficacy and better safety than FBT and was an attractive alternative to FBT for patients of ACRC, but further investigations in different populations would be needed to confirm it.

No MeSH data available.


Related in: MedlinePlus

Flow chart displaying the process of study selection for the meta-analysis.
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Related In: Results  -  Collection


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fig1: Flow chart displaying the process of study selection for the meta-analysis.

Mentions: The search strategy yielded 400 records. Of these, 79 duplicates were eliminated and 302 articles were excluded due to irrelevancy by reviewing their titles and abstracts. The remaining 19 records were obtained to further determine eligibility. We ruled out another five articles: two articles due to single arm trials [25, 26], one article due to pooled analysis [27], and two trials not comparing SBT with FBT [28, 29]. So ten full texts [6, 7, 9, 11–17] and four abstracts [8, 10, 18, 19] were identified according to the inclusion criteria, of which the trial reported by Otsuji et al. [19] was the updated study of partial result of the trial reported by Ojima et al. [10], and the trial reported by Baba et al. [18] was the updated study of partial result of the trial reported by Muro et al. [9]. Thus, only twelve studies [6–17] assessing 1625 participants qualified to be included for this meta-analysis, as described in the flow chart (Figure 1). Table 1 displayed the characteristics of these twelve individual trials with respect to author (year), country, demographic data, duration, intervention, outcome measure, and study design.


Effectiveness and safety of s-1-based therapy compared with 5-Fluorouracil-based therapy for advanced colorectal cancer: a meta-analysis.

Ye J, Chen J, Ge L, Liu A, Zhou S - Gastroenterol Res Pract (2014)

Flow chart displaying the process of study selection for the meta-analysis.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4265705&req=5

fig1: Flow chart displaying the process of study selection for the meta-analysis.
Mentions: The search strategy yielded 400 records. Of these, 79 duplicates were eliminated and 302 articles were excluded due to irrelevancy by reviewing their titles and abstracts. The remaining 19 records were obtained to further determine eligibility. We ruled out another five articles: two articles due to single arm trials [25, 26], one article due to pooled analysis [27], and two trials not comparing SBT with FBT [28, 29]. So ten full texts [6, 7, 9, 11–17] and four abstracts [8, 10, 18, 19] were identified according to the inclusion criteria, of which the trial reported by Otsuji et al. [19] was the updated study of partial result of the trial reported by Ojima et al. [10], and the trial reported by Baba et al. [18] was the updated study of partial result of the trial reported by Muro et al. [9]. Thus, only twelve studies [6–17] assessing 1625 participants qualified to be included for this meta-analysis, as described in the flow chart (Figure 1). Table 1 displayed the characteristics of these twelve individual trials with respect to author (year), country, demographic data, duration, intervention, outcome measure, and study design.

Bottom Line: The statistically significant differences in the meta-analysis indicated less incidence of graded 3-4 neutropenia (OR = 0.49, 95% CI = 0.35-0.68) and nausea/vomit (OR = 0.41, 95% CI = 0.23-0.72) in the SBT group, and there was no statistically significant difference in the incidence of grade 3-4 anemia, thrombocytopenia, leucopenia, diarrhea, and treatment-related deaths between two groups.Conclusions.SBT had similar efficacy and better safety than FBT and was an attractive alternative to FBT for patients of ACRC, but further investigations in different populations would be needed to confirm it.

View Article: PubMed Central - PubMed

Affiliation: Department of Medical Oncology, The Cancer Institute, Affiliated Tumor Hospital of Guangxi Medical University, Nanning, Guangxi 530021, China.

ABSTRACT
Objectives. The aim of our study was to compare the efficacy and safety of S-1-based therapy (SBT) versus 5-fluorouracil-based therapy (FBT) for advanced colorectal cancer (ACRC). Methods. A meta-analysis of all eligible randomized controlled trials (RCTs) was performed using RevMan 5.1.0 software. Results. A total of 1625 patients from twelve RCTs including 820 patients in the SBT group and 805 patients in the FBT group were available for analysis. The meta-analysis of overall survival (hazards ratio HR = 0.94, 95% CI = 0.80-1.10), progression-free survival (HR = 1.03, 95% CI = 0.91-1.18), and overall response rate (odds ratio OR = 1.23, 95% CI = 1.00-1.53) showed no statistical significance between SBT group and FBT group. The statistically significant differences in the meta-analysis indicated less incidence of graded 3-4 neutropenia (OR = 0.49, 95% CI = 0.35-0.68) and nausea/vomit (OR = 0.41, 95% CI = 0.23-0.72) in the SBT group, and there was no statistically significant difference in the incidence of grade 3-4 anemia, thrombocytopenia, leucopenia, diarrhea, and treatment-related deaths between two groups. Conclusions. SBT had similar efficacy and better safety than FBT and was an attractive alternative to FBT for patients of ACRC, but further investigations in different populations would be needed to confirm it.

No MeSH data available.


Related in: MedlinePlus