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Synthesis, Spectroscopic, Molecular Structure, and Antibacterial Studies of Dibutyltin(IV) Schiff Base Complexes Derived from Phenylalanine, Isoleucine, and Glycine.

Singh HL, Singh J - Bioinorg Chem Appl (2014)

Bottom Line: The results suggest that Schiff bases behave as monobasic bidentate ligands and coordinate with dibutyltin(IV) in octahedral geometry according to the general formula [Bu2Sn(L)2].Few representative compounds are tested for their in vitro antibacterial activity against Gram-positive (B. cereus, Staphylococcus spp.) and Gram-negative (E. coli, Klebsiella spp.) bacteria.The results show that the dibutyltin complexes are more reactive with respect to their corresponding Schiff base ligands.

View Article: PubMed Central - PubMed

Affiliation: Department of Chemistry, Faculty of Engineering & Technology, Mody University of Science and Technology, Laxmangarh, Sikar, Rajasthan 332311, India.

ABSTRACT
New series of organotin(IV) complexes and Schiff bases derived from amino acids have been designed and synthesized from condensation of 1H-indole-2,3-dione, 5-chloro-1H-indole-2,3-dione, and α-amino acids (phenylalanine, isoleucine, and glycine). All compounds are characterized by elemental analyses, molar conductance measurements, and molecular weight determinations. Bonding of these complexes is discussed in terms of their UV-visible, infrared, and nuclear magnetic resonance ((1)H, (13)C, and (119)Sn NMR) spectral studies. The results suggest that Schiff bases behave as monobasic bidentate ligands and coordinate with dibutyltin(IV) in octahedral geometry according to the general formula [Bu2Sn(L)2]. Elemental analyses and NMR spectral data of the ligands with their dibutyltin(IV) complexes agree with their proposed distorted octahedral structures. Few representative compounds are tested for their in vitro antibacterial activity against Gram-positive (B. cereus, Staphylococcus spp.) and Gram-negative (E. coli, Klebsiella spp.) bacteria. The results show that the dibutyltin complexes are more reactive with respect to their corresponding Schiff base ligands.

No MeSH data available.


Related in: MedlinePlus

Representative equation illustrating the formation of dibutyltin(IV) complexes.
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sch1: Representative equation illustrating the formation of dibutyltin(IV) complexes.

Mentions: New organotin(IV) complexes were synthesized by the reactions of dibutyltin(IV) oxide with Schiff bases, which have been carried out in 1 : 2 molar ratios using anhydrous benzene and absolute methanol in a 3 : 1 ratio as solvent. These reactions proceed with the liberation of water, which was azeotropically removed. The results of elemental analysis (C, H, and N) with molecular formula and the melting points are presented in Table 1. The results obtained are in good agreement with those calculated for the suggested formula. The scheme of the organotin(IV) complexes preparation is given below (Scheme 1).


Synthesis, Spectroscopic, Molecular Structure, and Antibacterial Studies of Dibutyltin(IV) Schiff Base Complexes Derived from Phenylalanine, Isoleucine, and Glycine.

Singh HL, Singh J - Bioinorg Chem Appl (2014)

Representative equation illustrating the formation of dibutyltin(IV) complexes.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4265522&req=5

sch1: Representative equation illustrating the formation of dibutyltin(IV) complexes.
Mentions: New organotin(IV) complexes were synthesized by the reactions of dibutyltin(IV) oxide with Schiff bases, which have been carried out in 1 : 2 molar ratios using anhydrous benzene and absolute methanol in a 3 : 1 ratio as solvent. These reactions proceed with the liberation of water, which was azeotropically removed. The results of elemental analysis (C, H, and N) with molecular formula and the melting points are presented in Table 1. The results obtained are in good agreement with those calculated for the suggested formula. The scheme of the organotin(IV) complexes preparation is given below (Scheme 1).

Bottom Line: The results suggest that Schiff bases behave as monobasic bidentate ligands and coordinate with dibutyltin(IV) in octahedral geometry according to the general formula [Bu2Sn(L)2].Few representative compounds are tested for their in vitro antibacterial activity against Gram-positive (B. cereus, Staphylococcus spp.) and Gram-negative (E. coli, Klebsiella spp.) bacteria.The results show that the dibutyltin complexes are more reactive with respect to their corresponding Schiff base ligands.

View Article: PubMed Central - PubMed

Affiliation: Department of Chemistry, Faculty of Engineering & Technology, Mody University of Science and Technology, Laxmangarh, Sikar, Rajasthan 332311, India.

ABSTRACT
New series of organotin(IV) complexes and Schiff bases derived from amino acids have been designed and synthesized from condensation of 1H-indole-2,3-dione, 5-chloro-1H-indole-2,3-dione, and α-amino acids (phenylalanine, isoleucine, and glycine). All compounds are characterized by elemental analyses, molar conductance measurements, and molecular weight determinations. Bonding of these complexes is discussed in terms of their UV-visible, infrared, and nuclear magnetic resonance ((1)H, (13)C, and (119)Sn NMR) spectral studies. The results suggest that Schiff bases behave as monobasic bidentate ligands and coordinate with dibutyltin(IV) in octahedral geometry according to the general formula [Bu2Sn(L)2]. Elemental analyses and NMR spectral data of the ligands with their dibutyltin(IV) complexes agree with their proposed distorted octahedral structures. Few representative compounds are tested for their in vitro antibacterial activity against Gram-positive (B. cereus, Staphylococcus spp.) and Gram-negative (E. coli, Klebsiella spp.) bacteria. The results show that the dibutyltin complexes are more reactive with respect to their corresponding Schiff base ligands.

No MeSH data available.


Related in: MedlinePlus