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Comparative Effects of Some Medicinal Plants: Anacardium occidentale, Eucalyptus globulus, Psidium guajava, and Xylopia aethiopica Extracts in Alloxan-Induced Diabetic Male Wistar Albino Rats.

Okpashi VE, Bayim BP, Obi-Abang M - Biochem Res Int (2014)

Bottom Line: There was no significant difference P > 0.05 recorded in the glutathione peroxidase activity of E. globulus (100 mg/kg) when compared to the test groups of P. guajava (250 mg/kg) and X. aethiopica (250 mg/kg).Catalase activity showed significant increase P < 0.05 in the catalase activity, compared to test groups.Therefore, a poly/combined formulation of these plants extracts yielded significant result as well as resolving some other complications associated with diabetics.

View Article: PubMed Central - PubMed

Affiliation: Department of Biochemistry, University of Nigeria, Nsukka, Nigeria.

ABSTRACT
Insulin therapy and oral antidiabetic agents/drugs used in the treatment of diabetes mellitus have not sufficiently proven to control hyperlipidemia, which is commonly associated with the diabetes mellitus. Again the hopes that traditional medicine and natural plants seem to trigger researchers in this area is yet to be discovered. This research was designed to compare the biochemical effects of some medicinal plants in alloxan-induced diabetic male Wistar rats using named plants that are best at lowering blood glucose and hyperlipidemia and ameliorating other complications of diabetes mellitus by methods of combined therapy. The results obtained showed 82% decrease in blood glucose concentration after the 10th hour to the fortieth hour. There was significant increase P < 0.05 in the superoxide dismutase activity of the test group administered 100 mg/kg of A. Occidentale. There was no significant difference P > 0.05 recorded in the glutathione peroxidase activity of E. globulus (100 mg/kg) when compared to the test groups of P. guajava (250 mg/kg) and X. aethiopica (250 mg/kg). Catalase activity showed significant increase P < 0.05 in the catalase activity, compared to test groups. While at P > 0.05, there was no significant difference seen between test group and treated groups. Meanwhile, degree of significance was observed in other parameters analysed. The biochemical analysis conducted in this study showed positive result, attesting to facts from previous works. Though these individual plants extracts exhibited significant increase in amelorating diabetes complication and blood glucose control compared to glibenclamide, a synthetic antidiabetic drug. Greater performance was observed in the synergy groups. Therefore, a poly/combined formulation of these plants extracts yielded significant result as well as resolving some other complications associated with diabetics.

No MeSH data available.


Related in: MedlinePlus

Comparative effect of the various plant extracts on vitamin C levels.
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fig11: Comparative effect of the various plant extracts on vitamin C levels.

Mentions: Figure 11 indicated a significant increase in antioxidant vitamin C, upon administration of various extracts on event of diabetes, resulting in decrease concentration of vitamin C after administration of A. occidentale, 250 mg/kg dose. Significant increase was noticeable P < 0.05. Thus significant increase in the test group administered 100 mg/kg of A. occidentale was shown, as compared to the groups that received A. occidentale (250 mg/kg), E. globulus (100, 250 mg/kg), P. guajava (250 mg/kg), and X. aethiopica (100 mg/kg). In Figure 11, there was significant difference P < 0.05 observed amongst groups that received A. occidentale (250 mg/kg), E. globulus (100 mg/kg), X. aethiopica (100 mg/kg), A. occidentale + E. globulus (100 mg/kg), P. guajava + X. aethiopica (100 mg/kg), and glibenclamide (5 mg/kg), compared to test group P. guajava (100 mg/kg). No significant difference P > 0.05 was indicated in groups A. occidentale (100 mg/kg), E. globulus (250 mg/kg), P. guajava (250 mg/kg), X. aethiopica (250 mg/kg), A. occidentale + E. globulus (250 mg/kg), and P. guajava + X. aethiopica (250 mg/kg). Between test group 6 and treatment groups 1, 2, 3, 7, 9, 10, 11, 13, and 14 there was significant increase P < 0.05 recorded. There were no significant differences P > 0.05 observed in groups 4, 5, 8, 12, and 15. Significantly there was a difference P < 0.05 observed in groups that received 100 mg/kg P. guajava + X. aethiopica (100 mg/kg) and treatment groups A. occidentale (250 mg/kg), E. globulus (100, 250 mg/kg), P. guajava (100, 250 mg/kg), X. aethiopica (100 mg/kg), and P. guajava + X. aethiopica (250 mg/kg) while no significant difference P > 0.05 was shown in groups given A. occidentale (100 mg/kg), X. aethiopica (100, 250 mg/kg), A. occidentale + E. globulus (100, 250 mg/kg), and 5 mg/kg of glibenclamide. In test group 12, a significant increase P < 0.05 was shown with regard to the vitamin C concentration compared to groups 2, 3, 7, 9, 11, 13, 14, and 15. There were no significant differences P > 0.05 recorded in groups 1, 4, 5, 6, 8, and 10.


Comparative Effects of Some Medicinal Plants: Anacardium occidentale, Eucalyptus globulus, Psidium guajava, and Xylopia aethiopica Extracts in Alloxan-Induced Diabetic Male Wistar Albino Rats.

Okpashi VE, Bayim BP, Obi-Abang M - Biochem Res Int (2014)

Comparative effect of the various plant extracts on vitamin C levels.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4265521&req=5

fig11: Comparative effect of the various plant extracts on vitamin C levels.
Mentions: Figure 11 indicated a significant increase in antioxidant vitamin C, upon administration of various extracts on event of diabetes, resulting in decrease concentration of vitamin C after administration of A. occidentale, 250 mg/kg dose. Significant increase was noticeable P < 0.05. Thus significant increase in the test group administered 100 mg/kg of A. occidentale was shown, as compared to the groups that received A. occidentale (250 mg/kg), E. globulus (100, 250 mg/kg), P. guajava (250 mg/kg), and X. aethiopica (100 mg/kg). In Figure 11, there was significant difference P < 0.05 observed amongst groups that received A. occidentale (250 mg/kg), E. globulus (100 mg/kg), X. aethiopica (100 mg/kg), A. occidentale + E. globulus (100 mg/kg), P. guajava + X. aethiopica (100 mg/kg), and glibenclamide (5 mg/kg), compared to test group P. guajava (100 mg/kg). No significant difference P > 0.05 was indicated in groups A. occidentale (100 mg/kg), E. globulus (250 mg/kg), P. guajava (250 mg/kg), X. aethiopica (250 mg/kg), A. occidentale + E. globulus (250 mg/kg), and P. guajava + X. aethiopica (250 mg/kg). Between test group 6 and treatment groups 1, 2, 3, 7, 9, 10, 11, 13, and 14 there was significant increase P < 0.05 recorded. There were no significant differences P > 0.05 observed in groups 4, 5, 8, 12, and 15. Significantly there was a difference P < 0.05 observed in groups that received 100 mg/kg P. guajava + X. aethiopica (100 mg/kg) and treatment groups A. occidentale (250 mg/kg), E. globulus (100, 250 mg/kg), P. guajava (100, 250 mg/kg), X. aethiopica (100 mg/kg), and P. guajava + X. aethiopica (250 mg/kg) while no significant difference P > 0.05 was shown in groups given A. occidentale (100 mg/kg), X. aethiopica (100, 250 mg/kg), A. occidentale + E. globulus (100, 250 mg/kg), and 5 mg/kg of glibenclamide. In test group 12, a significant increase P < 0.05 was shown with regard to the vitamin C concentration compared to groups 2, 3, 7, 9, 11, 13, 14, and 15. There were no significant differences P > 0.05 recorded in groups 1, 4, 5, 6, 8, and 10.

Bottom Line: There was no significant difference P > 0.05 recorded in the glutathione peroxidase activity of E. globulus (100 mg/kg) when compared to the test groups of P. guajava (250 mg/kg) and X. aethiopica (250 mg/kg).Catalase activity showed significant increase P < 0.05 in the catalase activity, compared to test groups.Therefore, a poly/combined formulation of these plants extracts yielded significant result as well as resolving some other complications associated with diabetics.

View Article: PubMed Central - PubMed

Affiliation: Department of Biochemistry, University of Nigeria, Nsukka, Nigeria.

ABSTRACT
Insulin therapy and oral antidiabetic agents/drugs used in the treatment of diabetes mellitus have not sufficiently proven to control hyperlipidemia, which is commonly associated with the diabetes mellitus. Again the hopes that traditional medicine and natural plants seem to trigger researchers in this area is yet to be discovered. This research was designed to compare the biochemical effects of some medicinal plants in alloxan-induced diabetic male Wistar rats using named plants that are best at lowering blood glucose and hyperlipidemia and ameliorating other complications of diabetes mellitus by methods of combined therapy. The results obtained showed 82% decrease in blood glucose concentration after the 10th hour to the fortieth hour. There was significant increase P < 0.05 in the superoxide dismutase activity of the test group administered 100 mg/kg of A. Occidentale. There was no significant difference P > 0.05 recorded in the glutathione peroxidase activity of E. globulus (100 mg/kg) when compared to the test groups of P. guajava (250 mg/kg) and X. aethiopica (250 mg/kg). Catalase activity showed significant increase P < 0.05 in the catalase activity, compared to test groups. While at P > 0.05, there was no significant difference seen between test group and treated groups. Meanwhile, degree of significance was observed in other parameters analysed. The biochemical analysis conducted in this study showed positive result, attesting to facts from previous works. Though these individual plants extracts exhibited significant increase in amelorating diabetes complication and blood glucose control compared to glibenclamide, a synthetic antidiabetic drug. Greater performance was observed in the synergy groups. Therefore, a poly/combined formulation of these plants extracts yielded significant result as well as resolving some other complications associated with diabetics.

No MeSH data available.


Related in: MedlinePlus