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Comparative Effects of Some Medicinal Plants: Anacardium occidentale, Eucalyptus globulus, Psidium guajava, and Xylopia aethiopica Extracts in Alloxan-Induced Diabetic Male Wistar Albino Rats.

Okpashi VE, Bayim BP, Obi-Abang M - Biochem Res Int (2014)

Bottom Line: There was no significant difference P > 0.05 recorded in the glutathione peroxidase activity of E. globulus (100 mg/kg) when compared to the test groups of P. guajava (250 mg/kg) and X. aethiopica (250 mg/kg).Catalase activity showed significant increase P < 0.05 in the catalase activity, compared to test groups.Therefore, a poly/combined formulation of these plants extracts yielded significant result as well as resolving some other complications associated with diabetics.

View Article: PubMed Central - PubMed

Affiliation: Department of Biochemistry, University of Nigeria, Nsukka, Nigeria.

ABSTRACT
Insulin therapy and oral antidiabetic agents/drugs used in the treatment of diabetes mellitus have not sufficiently proven to control hyperlipidemia, which is commonly associated with the diabetes mellitus. Again the hopes that traditional medicine and natural plants seem to trigger researchers in this area is yet to be discovered. This research was designed to compare the biochemical effects of some medicinal plants in alloxan-induced diabetic male Wistar rats using named plants that are best at lowering blood glucose and hyperlipidemia and ameliorating other complications of diabetes mellitus by methods of combined therapy. The results obtained showed 82% decrease in blood glucose concentration after the 10th hour to the fortieth hour. There was significant increase P < 0.05 in the superoxide dismutase activity of the test group administered 100 mg/kg of A. Occidentale. There was no significant difference P > 0.05 recorded in the glutathione peroxidase activity of E. globulus (100 mg/kg) when compared to the test groups of P. guajava (250 mg/kg) and X. aethiopica (250 mg/kg). Catalase activity showed significant increase P < 0.05 in the catalase activity, compared to test groups. While at P > 0.05, there was no significant difference seen between test group and treated groups. Meanwhile, degree of significance was observed in other parameters analysed. The biochemical analysis conducted in this study showed positive result, attesting to facts from previous works. Though these individual plants extracts exhibited significant increase in amelorating diabetes complication and blood glucose control compared to glibenclamide, a synthetic antidiabetic drug. Greater performance was observed in the synergy groups. Therefore, a poly/combined formulation of these plants extracts yielded significant result as well as resolving some other complications associated with diabetics.

No MeSH data available.


Related in: MedlinePlus

Comparative effects of some plants extracts in the superoxide dismutase activity.
© Copyright Policy - open-access
Related In: Results  -  Collection


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fig2: Comparative effects of some plants extracts in the superoxide dismutase activity.

Mentions: Figure 2 indicates the superoxide dismutase activities of the experimental rats, showing the effect of various extracts at variable doses. The diabetic untreated group had the least activity and upon administration of these extracts culminated in appreciable increase in the SOD activity of the treated groups. Figure 2 also indicated significant P < 0.05 in superoxide dismutase activity of test group administered 100 mg/kg of A. occidentale compared to groups treated with E. globulus (100, 250 mg/kg), P. guajava (250 mg/kg), X. aethiopica (100, 250 mg/kg), A. occidentale + E. globulus (100, 250 mg/kg), P. guajava + X. aethiopica (100, 250 mg/kg), and glibenclamide (5 mg/kg), respectively. Meanwhile no significant difference P > 0.05 was observed in groups administered with A. occidentale (250 mg/kg) and P. guajava (100 mg/kg). A significant P < 0.05 was found between 250 mg/kg, A. occidentale treated group, and test groups E. globulus (250 mg/kg), X. aethiopica (100 mg/kg), A. occidentale + E. globulus (100, 250 mg/kg), P. guajava + X. aethiopica (100, 250 mg/kg), glibenclamide (5 mg/kg), and diabetic untreated. There was no significant difference P > 0.05 in the A. occidentale 250 mg/kg compared to groups A. occidentale (100 mg/kg), E. globulus (100 mg/kg), P. guajava (100, 250 mg/kg), X. aethiopica, and DMSO control.


Comparative Effects of Some Medicinal Plants: Anacardium occidentale, Eucalyptus globulus, Psidium guajava, and Xylopia aethiopica Extracts in Alloxan-Induced Diabetic Male Wistar Albino Rats.

Okpashi VE, Bayim BP, Obi-Abang M - Biochem Res Int (2014)

Comparative effects of some plants extracts in the superoxide dismutase activity.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4265521&req=5

fig2: Comparative effects of some plants extracts in the superoxide dismutase activity.
Mentions: Figure 2 indicates the superoxide dismutase activities of the experimental rats, showing the effect of various extracts at variable doses. The diabetic untreated group had the least activity and upon administration of these extracts culminated in appreciable increase in the SOD activity of the treated groups. Figure 2 also indicated significant P < 0.05 in superoxide dismutase activity of test group administered 100 mg/kg of A. occidentale compared to groups treated with E. globulus (100, 250 mg/kg), P. guajava (250 mg/kg), X. aethiopica (100, 250 mg/kg), A. occidentale + E. globulus (100, 250 mg/kg), P. guajava + X. aethiopica (100, 250 mg/kg), and glibenclamide (5 mg/kg), respectively. Meanwhile no significant difference P > 0.05 was observed in groups administered with A. occidentale (250 mg/kg) and P. guajava (100 mg/kg). A significant P < 0.05 was found between 250 mg/kg, A. occidentale treated group, and test groups E. globulus (250 mg/kg), X. aethiopica (100 mg/kg), A. occidentale + E. globulus (100, 250 mg/kg), P. guajava + X. aethiopica (100, 250 mg/kg), glibenclamide (5 mg/kg), and diabetic untreated. There was no significant difference P > 0.05 in the A. occidentale 250 mg/kg compared to groups A. occidentale (100 mg/kg), E. globulus (100 mg/kg), P. guajava (100, 250 mg/kg), X. aethiopica, and DMSO control.

Bottom Line: There was no significant difference P > 0.05 recorded in the glutathione peroxidase activity of E. globulus (100 mg/kg) when compared to the test groups of P. guajava (250 mg/kg) and X. aethiopica (250 mg/kg).Catalase activity showed significant increase P < 0.05 in the catalase activity, compared to test groups.Therefore, a poly/combined formulation of these plants extracts yielded significant result as well as resolving some other complications associated with diabetics.

View Article: PubMed Central - PubMed

Affiliation: Department of Biochemistry, University of Nigeria, Nsukka, Nigeria.

ABSTRACT
Insulin therapy and oral antidiabetic agents/drugs used in the treatment of diabetes mellitus have not sufficiently proven to control hyperlipidemia, which is commonly associated with the diabetes mellitus. Again the hopes that traditional medicine and natural plants seem to trigger researchers in this area is yet to be discovered. This research was designed to compare the biochemical effects of some medicinal plants in alloxan-induced diabetic male Wistar rats using named plants that are best at lowering blood glucose and hyperlipidemia and ameliorating other complications of diabetes mellitus by methods of combined therapy. The results obtained showed 82% decrease in blood glucose concentration after the 10th hour to the fortieth hour. There was significant increase P < 0.05 in the superoxide dismutase activity of the test group administered 100 mg/kg of A. Occidentale. There was no significant difference P > 0.05 recorded in the glutathione peroxidase activity of E. globulus (100 mg/kg) when compared to the test groups of P. guajava (250 mg/kg) and X. aethiopica (250 mg/kg). Catalase activity showed significant increase P < 0.05 in the catalase activity, compared to test groups. While at P > 0.05, there was no significant difference seen between test group and treated groups. Meanwhile, degree of significance was observed in other parameters analysed. The biochemical analysis conducted in this study showed positive result, attesting to facts from previous works. Though these individual plants extracts exhibited significant increase in amelorating diabetes complication and blood glucose control compared to glibenclamide, a synthetic antidiabetic drug. Greater performance was observed in the synergy groups. Therefore, a poly/combined formulation of these plants extracts yielded significant result as well as resolving some other complications associated with diabetics.

No MeSH data available.


Related in: MedlinePlus