High-resolution diffusion tensor imaging of the human kidneys using a free-breathing, multi-slice, targeted field of view approach.
Bottom Line: The mean medulla and cortical FA values were 0.38 ± 0.017 and 0.21 ± 0.019, respectively, for the dual-kidney scan, and 0.35 ± 0.032 and 0.20 ± 0.014, respectively, for the single-kidney scan.The mean FA between the medulla and cortex was significantly different (p < 0.001) for both dual- and single-kidney implementations.High-spatial-resolution DTI shows promise for improving the characterization and non-invasive assessment of kidney function.
Affiliation: Centre for Medical Imaging, University College London, London, UK.Show MeSH
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Mentions: Consistency between TFOV D and S in the cFA and diffusion tensors can be seen in a representative slice in Fig. 3. The kidney that was imaged by both TFOV D and S was compared in terms of the greyscale FA maps, thresholded FA and thresholded cFA in Fig. 3a, b. The medulla regions correspond to the darker regions seen in the anatomical gradient-echo scan in Fig. 3c. A comparison of the diffusion tensor maps is shown in Fig. 3d. All images show good correspondence between TFOV D and S, including similar medulla regions (as delineated by thresholding) and spatial variation of the diffusion directions (as indicated by the cFA maps and by the vector directions in the diffusion tensor maps). The radial diffusion pattern is evident in the tensor maps, and is seen at higher resolution in TFOV S relative to TFOV D.
Affiliation: Centre for Medical Imaging, University College London, London, UK.