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High-resolution diffusion tensor imaging of the human kidneys using a free-breathing, multi-slice, targeted field of view approach.

Chan RW, Von Deuster C, Stoeck CT, Harmer J, Punwani S, Ramachandran N, Kozerke S, Atkinson D - NMR Biomed (2014)

Bottom Line: The mean medulla and cortical FA values were 0.38 ± 0.017 and 0.21 ± 0.019, respectively, for the dual-kidney scan, and 0.35 ± 0.032 and 0.20 ± 0.014, respectively, for the single-kidney scan.The mean FA between the medulla and cortex was significantly different (p < 0.001) for both dual- and single-kidney implementations.High-spatial-resolution DTI shows promise for improving the characterization and non-invasive assessment of kidney function.

View Article: PubMed Central - PubMed

Affiliation: Centre for Medical Imaging, University College London, London, UK.

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Fractional anisotropy (FA) values and signal-to-noise ratio (SNR) analysis for comparison scans. (a) Medulla and cortical FA values for three subjects imaged with three sequences [full field of view (full FOV), dual-kidney targeted FOV (TFOV D) and single-kidney targeted FOV (TFOV S)]. FA values were derived from images reconstructed from all three signal averages. (b) SNR plots for the same three subjects. Means and standard deviations (over the subjects) are shown, as well as the individual SNRs for each scan of each subject. Images were reconstructed with different numbers of signal averages 1–3 for the SNR comparison.
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fig10: Fractional anisotropy (FA) values and signal-to-noise ratio (SNR) analysis for comparison scans. (a) Medulla and cortical FA values for three subjects imaged with three sequences [full field of view (full FOV), dual-kidney targeted FOV (TFOV D) and single-kidney targeted FOV (TFOV S)]. FA values were derived from images reconstructed from all three signal averages. (b) SNR plots for the same three subjects. Means and standard deviations (over the subjects) are shown, as well as the individual SNRs for each scan of each subject. Images were reconstructed with different numbers of signal averages 1–3 for the SNR comparison.

Mentions: The plots in Fig. 10a show the medulla and cortical FA computed from the three subjects who were scanned with three sequences. For the full-FOV, TFOV D and TFOV S scans, the mean medulla FA values were 0.32 ± 0.027, 0.34 ± 0.022 and 0.33 ± 0.023, and the mean cortical FA values were 0.18 ± 0.012, 0.17 ± 0.006 and 0.18 ± 0.026, respectively. Results from the SNR analysis in Fig. 10b showed that the full FOV (with the lowest spatial resolution) had the highest SNR, followed by TFOV D, with the lowest SNR for TFOV S (with the highest spatial resolution). Using all three averages, the SNR was 45.2 ± 11.7 for full FOV, 18.6 ± 3.4 for TFOV D and 8.4 ± 0.8 for TFOV S. An explanation for the wider standard deviation is that there were fewer voxels in the kidney regions per subject as the voxel size increased. The SNR in the full-FOV scan is about five to six times higher than that of the smallest FOV.


High-resolution diffusion tensor imaging of the human kidneys using a free-breathing, multi-slice, targeted field of view approach.

Chan RW, Von Deuster C, Stoeck CT, Harmer J, Punwani S, Ramachandran N, Kozerke S, Atkinson D - NMR Biomed (2014)

Fractional anisotropy (FA) values and signal-to-noise ratio (SNR) analysis for comparison scans. (a) Medulla and cortical FA values for three subjects imaged with three sequences [full field of view (full FOV), dual-kidney targeted FOV (TFOV D) and single-kidney targeted FOV (TFOV S)]. FA values were derived from images reconstructed from all three signal averages. (b) SNR plots for the same three subjects. Means and standard deviations (over the subjects) are shown, as well as the individual SNRs for each scan of each subject. Images were reconstructed with different numbers of signal averages 1–3 for the SNR comparison.
© Copyright Policy - open-access
Related In: Results  -  Collection

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getmorefigures.php?uid=PMC4265306&req=5

fig10: Fractional anisotropy (FA) values and signal-to-noise ratio (SNR) analysis for comparison scans. (a) Medulla and cortical FA values for three subjects imaged with three sequences [full field of view (full FOV), dual-kidney targeted FOV (TFOV D) and single-kidney targeted FOV (TFOV S)]. FA values were derived from images reconstructed from all three signal averages. (b) SNR plots for the same three subjects. Means and standard deviations (over the subjects) are shown, as well as the individual SNRs for each scan of each subject. Images were reconstructed with different numbers of signal averages 1–3 for the SNR comparison.
Mentions: The plots in Fig. 10a show the medulla and cortical FA computed from the three subjects who were scanned with three sequences. For the full-FOV, TFOV D and TFOV S scans, the mean medulla FA values were 0.32 ± 0.027, 0.34 ± 0.022 and 0.33 ± 0.023, and the mean cortical FA values were 0.18 ± 0.012, 0.17 ± 0.006 and 0.18 ± 0.026, respectively. Results from the SNR analysis in Fig. 10b showed that the full FOV (with the lowest spatial resolution) had the highest SNR, followed by TFOV D, with the lowest SNR for TFOV S (with the highest spatial resolution). Using all three averages, the SNR was 45.2 ± 11.7 for full FOV, 18.6 ± 3.4 for TFOV D and 8.4 ± 0.8 for TFOV S. An explanation for the wider standard deviation is that there were fewer voxels in the kidney regions per subject as the voxel size increased. The SNR in the full-FOV scan is about five to six times higher than that of the smallest FOV.

Bottom Line: The mean medulla and cortical FA values were 0.38 ± 0.017 and 0.21 ± 0.019, respectively, for the dual-kidney scan, and 0.35 ± 0.032 and 0.20 ± 0.014, respectively, for the single-kidney scan.The mean FA between the medulla and cortex was significantly different (p < 0.001) for both dual- and single-kidney implementations.High-spatial-resolution DTI shows promise for improving the characterization and non-invasive assessment of kidney function.

View Article: PubMed Central - PubMed

Affiliation: Centre for Medical Imaging, University College London, London, UK.

Show MeSH