High-resolution diffusion tensor imaging of the human kidneys using a free-breathing, multi-slice, targeted field of view approach.
Bottom Line: The mean medulla and cortical FA values were 0.38 ± 0.017 and 0.21 ± 0.019, respectively, for the dual-kidney scan, and 0.35 ± 0.032 and 0.20 ± 0.014, respectively, for the single-kidney scan.The mean FA between the medulla and cortex was significantly different (p < 0.001) for both dual- and single-kidney implementations.High-spatial-resolution DTI shows promise for improving the characterization and non-invasive assessment of kidney function.
Affiliation: Centre for Medical Imaging, University College London, London, UK.Show MeSH
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Mentions: The plots in Fig. 10a show the medulla and cortical FA computed from the three subjects who were scanned with three sequences. For the full-FOV, TFOV D and TFOV S scans, the mean medulla FA values were 0.32 ± 0.027, 0.34 ± 0.022 and 0.33 ± 0.023, and the mean cortical FA values were 0.18 ± 0.012, 0.17 ± 0.006 and 0.18 ± 0.026, respectively. Results from the SNR analysis in Fig. 10b showed that the full FOV (with the lowest spatial resolution) had the highest SNR, followed by TFOV D, with the lowest SNR for TFOV S (with the highest spatial resolution). Using all three averages, the SNR was 45.2 ± 11.7 for full FOV, 18.6 ± 3.4 for TFOV D and 8.4 ± 0.8 for TFOV S. An explanation for the wider standard deviation is that there were fewer voxels in the kidney regions per subject as the voxel size increased. The SNR in the full-FOV scan is about five to six times higher than that of the smallest FOV.
Affiliation: Centre for Medical Imaging, University College London, London, UK.