Hypercaloric diets with increased meal frequency, but not meal size, increase intrahepatic triglycerides: a randomized controlled trial.
Bottom Line: We hypothesized that a high meal frequency, compared to consuming large meals, is detrimental in the accumulation of intrahepatic and abdominal fat.Increasing meal frequency significantly increased IHTG (HFHS mean relative increase of 45%; P = 0.016 and HS mean relative increase of 110%; P = 0.047), whereas increasing meal size did not (2-way analysis of variance [ANOVA] size versus frequency P = 0.03).Abdominal fat increased in the HFHS-frequency group (+63.3 ± 42.8 mL; P = 0.004) and tended to increase in the HS-frequency group (+46.5 ± 50.7 mL; P = 0.08).
Affiliation: Department of Endocrinology & Metabolism, Academic Medical Centre Amsterdam, Netherlands.Show MeSH
Related in: MedlinePlus
Mentions: Food intake and macronutrient composition during the hypercaloric interventions are presented in Table2 and Fig. 2A. In summary, ad libitum nutrient intake was similar between the four diet groups. There was no difference in carbohydrate and fat intake between both HS groups or between both HFHS groups. There were no side effects or adverse events reported by subjects on any of the four diets.
Affiliation: Department of Endocrinology & Metabolism, Academic Medical Centre Amsterdam, Netherlands.