Genome-wide association study of height-adjusted BMI in childhood identifies functional variant in ADCY3.
Bottom Line: SNPs in ADCY3 (adenylate cyclase 3) were associated at genome-wide significance level (rs11676272 (0.28 kg/m(3.1) change per allele G (0.19, 0.38), P = 6 × 10(-9) ).The association signal at ADCY3 appeared to be driven by a missense variant and it was strongly correlated with expression of this gene.Our work highlights the importance of well understood phenotype use (and the danger of convention) in characterising genetic contributions to complex traits.
Affiliation: MRC Integrative Epidemiology Unit at the University of Bristol, Bristol, UK.Show MeSH
Related in: MedlinePlus
Affiliation: MRC Integrative Epidemiology Unit at the University of Bristol, Bristol, UK.