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Genome-wide association study of height-adjusted BMI in childhood identifies functional variant in ADCY3.

Stergiakouli E, Gaillard R, Tavaré JM, Balthasar N, Loos RJ, Taal HR, Evans DM, Rivadeneira F, St Pourcain B, Uitterlinden AG, Kemp JP, Hofman A, Ring SM, Cole TJ, Jaddoe VW, Davey Smith G, Timpson NJ - Obesity (Silver Spring) (2014)

Bottom Line: SNPs in ADCY3 (adenylate cyclase 3) were associated at genome-wide significance level (rs11676272 (0.28 kg/m(3.1) change per allele G (0.19, 0.38), P = 6 × 10(-9) ).The association signal at ADCY3 appeared to be driven by a missense variant and it was strongly correlated with expression of this gene.Our work highlights the importance of well understood phenotype use (and the danger of convention) in characterising genetic contributions to complex traits.

View Article: PubMed Central - PubMed

Affiliation: MRC Integrative Epidemiology Unit at the University of Bristol, Bristol, UK.

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In situ hybridization data from the Allen Mouse Brain Atlas. Darker staining is seen in coronal sections of adult mouse brains indicating ADCY3 (adenylate cyclase 3) mRNA expression within the hypothalamus, including the (a) suprachiasmatic, (b) paraventricular, (c) ventromedial, and (d) arcuate nucleus. Data from Allen Mouse Brain Atlas 35 (http://mouse.brainmap.org/experiment/ivt?id=75&popup=true). [Color figure can be viewed in the online issue, which is available at wileyonlinelibrary.com.]
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fig06: In situ hybridization data from the Allen Mouse Brain Atlas. Darker staining is seen in coronal sections of adult mouse brains indicating ADCY3 (adenylate cyclase 3) mRNA expression within the hypothalamus, including the (a) suprachiasmatic, (b) paraventricular, (c) ventromedial, and (d) arcuate nucleus. Data from Allen Mouse Brain Atlas 35 (http://mouse.brainmap.org/experiment/ivt?id=75&popup=true). [Color figure can be viewed in the online issue, which is available at wileyonlinelibrary.com.]


Genome-wide association study of height-adjusted BMI in childhood identifies functional variant in ADCY3.

Stergiakouli E, Gaillard R, Tavaré JM, Balthasar N, Loos RJ, Taal HR, Evans DM, Rivadeneira F, St Pourcain B, Uitterlinden AG, Kemp JP, Hofman A, Ring SM, Cole TJ, Jaddoe VW, Davey Smith G, Timpson NJ - Obesity (Silver Spring) (2014)

In situ hybridization data from the Allen Mouse Brain Atlas. Darker staining is seen in coronal sections of adult mouse brains indicating ADCY3 (adenylate cyclase 3) mRNA expression within the hypothalamus, including the (a) suprachiasmatic, (b) paraventricular, (c) ventromedial, and (d) arcuate nucleus. Data from Allen Mouse Brain Atlas 35 (http://mouse.brainmap.org/experiment/ivt?id=75&popup=true). [Color figure can be viewed in the online issue, which is available at wileyonlinelibrary.com.]
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4265207&req=5

fig06: In situ hybridization data from the Allen Mouse Brain Atlas. Darker staining is seen in coronal sections of adult mouse brains indicating ADCY3 (adenylate cyclase 3) mRNA expression within the hypothalamus, including the (a) suprachiasmatic, (b) paraventricular, (c) ventromedial, and (d) arcuate nucleus. Data from Allen Mouse Brain Atlas 35 (http://mouse.brainmap.org/experiment/ivt?id=75&popup=true). [Color figure can be viewed in the online issue, which is available at wileyonlinelibrary.com.]
Bottom Line: SNPs in ADCY3 (adenylate cyclase 3) were associated at genome-wide significance level (rs11676272 (0.28 kg/m(3.1) change per allele G (0.19, 0.38), P = 6 × 10(-9) ).The association signal at ADCY3 appeared to be driven by a missense variant and it was strongly correlated with expression of this gene.Our work highlights the importance of well understood phenotype use (and the danger of convention) in characterising genetic contributions to complex traits.

View Article: PubMed Central - PubMed

Affiliation: MRC Integrative Epidemiology Unit at the University of Bristol, Bristol, UK.

Show MeSH