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The associations of adipokines with selected markers of the renin-angiotensinogen-aldosterone system: the multi-ethnic study of atherosclerosis.

Allison MA, Jenny NS, McClelland RL, Cushman M, Rifkin D - J Hum Hypertens (2014)

Bottom Line: Although adiponectin was not significantly associated with PRA levels, the same increment in this adipokine was associated with lower aldosterone levels (-5.5 pg ml(-1), P=0.01).Exclusion of those taking antihypertensive medications modestly attenuated the associations.The findings suggest that both adiponectin and leptin may be relevant to blood pressure regulation via the RAAS, in that the associations appear to be robust to antihypertension medication use and that the associations are likely different by ethnicity.

View Article: PubMed Central - PubMed

Affiliation: Department of Family and Preventive Medicine, University of California-San Diego, La Jolla, CA, USA.

ABSTRACT
Among obese individuals, increased sympathetic nervous system (SNS) activity results in increased renin and aldosterone production, as well as renal tubular sodium reabsorption. This study determined the associations between adipokines and selected measures of the renin-angiotensinogen-aldosterone system (RAAS). The sample consisted of 1970 men and women from the Multi-Ethnic Study of Atherosclerosis who were free of clinical cardiovascular disease at baseline and had blood assayed for adiponectin, leptin, plasma renin activity (PRA) and aldosterone. The mean age was 64.7 years and 50% were female. The mean (s.d.) PRA and aldosterone were 1.45 (0.56) ng ml(-1) and 150.1 (130.5) pg ml(-1), respectively. After multivariable adjustment, a 1-s.d. increment of leptin was associated with a 0.55 ng ml(-1) higher PRA and 8.4 pg ml(-1) higher aldosterone (P<0.01 for both). Although adiponectin was not significantly associated with PRA levels, the same increment in this adipokine was associated with lower aldosterone levels (-5.5 pg ml(-1), P=0.01). Notably, the associations between aldosterone and both leptin and adiponectin were not materially changed with additional adjustment for PRA. Exclusion of those taking antihypertensive medications modestly attenuated the associations. The associations between leptin and both PRA and aldosterone were not different by gender but were significantly stronger among non-Hispanic Whites and Chinese Americans than African and Hispanic Americans (P<0.01). The findings suggest that both adiponectin and leptin may be relevant to blood pressure regulation via the RAAS, in that the associations appear to be robust to antihypertension medication use and that the associations are likely different by ethnicity.

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Related in: MedlinePlus

DIFFERENCES IN LEVELS OF ALDOSTERONE BY QUARTILES OF LEPTIN AND ADIPONECTINReferent Category = Quartile 1; Q2 = 2nd Quartile, Q3 = 3rd Quartile, Q4 = 4th Quartile Adjusted for age, gender, race/ethnicity, body mass index, diabetes, dyslipidemia, smoking and estimated glomerular filtration rate
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Figure 2: DIFFERENCES IN LEVELS OF ALDOSTERONE BY QUARTILES OF LEPTIN AND ADIPONECTINReferent Category = Quartile 1; Q2 = 2nd Quartile, Q3 = 3rd Quartile, Q4 = 4th Quartile Adjusted for age, gender, race/ethnicity, body mass index, diabetes, dyslipidemia, smoking and estimated glomerular filtration rate

Mentions: The results of multivariable linear regression when adiponectin was considered as a categorical variable and divided into quartiles are provided in Figures 1 & 2. Compared to the lowest quartile and after adjustment for age, gender and race/ethnicity, there were modest, non-significant differences in PRA with each higher quartile of adiponectin (Figure 1), which was not changed after full adjustment. Conversely, after multivariable adjustment, there were step-wise increases in the differences in aldosterone with each higher quartile of adiponectin (Figure 2). More specifically, compared to the 1st quartile, the 2nd, 3rd and 4th quartiles of adiponectin were associated with 9.8 (p = 0.08), 10.7 (p = 0.08) and 22.8 (p < 0.01) pg/ml lower aldosterone levels. Addition of leptin to the models described above, as well as PRA to the models where aldosterone was the outcome, did not materially change the findings.


The associations of adipokines with selected markers of the renin-angiotensinogen-aldosterone system: the multi-ethnic study of atherosclerosis.

Allison MA, Jenny NS, McClelland RL, Cushman M, Rifkin D - J Hum Hypertens (2014)

DIFFERENCES IN LEVELS OF ALDOSTERONE BY QUARTILES OF LEPTIN AND ADIPONECTINReferent Category = Quartile 1; Q2 = 2nd Quartile, Q3 = 3rd Quartile, Q4 = 4th Quartile Adjusted for age, gender, race/ethnicity, body mass index, diabetes, dyslipidemia, smoking and estimated glomerular filtration rate
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4265023&req=5

Figure 2: DIFFERENCES IN LEVELS OF ALDOSTERONE BY QUARTILES OF LEPTIN AND ADIPONECTINReferent Category = Quartile 1; Q2 = 2nd Quartile, Q3 = 3rd Quartile, Q4 = 4th Quartile Adjusted for age, gender, race/ethnicity, body mass index, diabetes, dyslipidemia, smoking and estimated glomerular filtration rate
Mentions: The results of multivariable linear regression when adiponectin was considered as a categorical variable and divided into quartiles are provided in Figures 1 & 2. Compared to the lowest quartile and after adjustment for age, gender and race/ethnicity, there were modest, non-significant differences in PRA with each higher quartile of adiponectin (Figure 1), which was not changed after full adjustment. Conversely, after multivariable adjustment, there were step-wise increases in the differences in aldosterone with each higher quartile of adiponectin (Figure 2). More specifically, compared to the 1st quartile, the 2nd, 3rd and 4th quartiles of adiponectin were associated with 9.8 (p = 0.08), 10.7 (p = 0.08) and 22.8 (p < 0.01) pg/ml lower aldosterone levels. Addition of leptin to the models described above, as well as PRA to the models where aldosterone was the outcome, did not materially change the findings.

Bottom Line: Although adiponectin was not significantly associated with PRA levels, the same increment in this adipokine was associated with lower aldosterone levels (-5.5 pg ml(-1), P=0.01).Exclusion of those taking antihypertensive medications modestly attenuated the associations.The findings suggest that both adiponectin and leptin may be relevant to blood pressure regulation via the RAAS, in that the associations appear to be robust to antihypertension medication use and that the associations are likely different by ethnicity.

View Article: PubMed Central - PubMed

Affiliation: Department of Family and Preventive Medicine, University of California-San Diego, La Jolla, CA, USA.

ABSTRACT
Among obese individuals, increased sympathetic nervous system (SNS) activity results in increased renin and aldosterone production, as well as renal tubular sodium reabsorption. This study determined the associations between adipokines and selected measures of the renin-angiotensinogen-aldosterone system (RAAS). The sample consisted of 1970 men and women from the Multi-Ethnic Study of Atherosclerosis who were free of clinical cardiovascular disease at baseline and had blood assayed for adiponectin, leptin, plasma renin activity (PRA) and aldosterone. The mean age was 64.7 years and 50% were female. The mean (s.d.) PRA and aldosterone were 1.45 (0.56) ng ml(-1) and 150.1 (130.5) pg ml(-1), respectively. After multivariable adjustment, a 1-s.d. increment of leptin was associated with a 0.55 ng ml(-1) higher PRA and 8.4 pg ml(-1) higher aldosterone (P<0.01 for both). Although adiponectin was not significantly associated with PRA levels, the same increment in this adipokine was associated with lower aldosterone levels (-5.5 pg ml(-1), P=0.01). Notably, the associations between aldosterone and both leptin and adiponectin were not materially changed with additional adjustment for PRA. Exclusion of those taking antihypertensive medications modestly attenuated the associations. The associations between leptin and both PRA and aldosterone were not different by gender but were significantly stronger among non-Hispanic Whites and Chinese Americans than African and Hispanic Americans (P<0.01). The findings suggest that both adiponectin and leptin may be relevant to blood pressure regulation via the RAAS, in that the associations appear to be robust to antihypertension medication use and that the associations are likely different by ethnicity.

Show MeSH
Related in: MedlinePlus