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Hippocampal spatial position evaluation on MRI for research and clinical practice.

Mrzílkova J, Koutela A, Kutová M, Patzelt M, Ibrahim I, Al-Kayssi D, Bartoš A, Řípová D, Čermáková P, Zach P - PLoS ONE (2014)

Bottom Line: We found that 1) hippocampal area of nat images is larger compared to hipp images, area of the nat images is equal to the AC-PC images and area of the hipp images is smaller compared to AC-PC images, 2) hippocampal area together with the area of the temporal horn for nat images is larger compared to hipp images, area of the hipp images is smaller compared to the AC-PC images and area of the nat images is smaller compared to the AC-PC images.The conclusion is that the measured area of the hippocampus in the native MRI is almost the same as the area of MRI reoriented only into the AC-PC axis.Surprising finding was that rotation of both AC-PC and hipp line towards x-axis among patients varies up to 35° and the same is true for the skull rotation so that it is not only a matter of the brain position.

View Article: PubMed Central - PubMed

Affiliation: Institute of Anatomy, Third Faculty of Medicine, Charles University, Ruská 87, 100 00 Prague 10, Czech Republic.

ABSTRACT
In clinical practice as well as in many volumetric studies we use different reorientations of the brain position towards x and y axis on the magnetic resonance imaging (MRI) scans. In order to find out whether it has an overall effect on the resulting 2D data, manual hippocampal area measurements and rotation variability of the brain (in two reoriented axes) and the skull were performed in 23 Alzheimer's disease patients and 31 healthy controls. After the MRI scanning, native brain scans (nat) were reoriented into the two different artificial planes (anterior commissure-posterior commissure axis (AC-PC) and hippocampal horizontal long axis (hipp)). Hippocampal area and temporal horn of the lateral ventricle was measured manually using freeware Image J program. We found that 1) hippocampal area of nat images is larger compared to hipp images, area of the nat images is equal to the AC-PC images and area of the hipp images is smaller compared to AC-PC images, 2) hippocampal area together with the area of the temporal horn for nat images is larger compared to hipp images, area of the hipp images is smaller compared to the AC-PC images and area of the nat images is smaller compared to the AC-PC images. The conclusion is that the measured area of the hippocampus in the native MRI is almost the same as the area of MRI reoriented only into the AC-PC axis. Therefore, when performing 2D area studies of the hippocampus or in the clinical practice we recommend usage of not-reoriented MRI images or to reorient them into the AC-PC axis. Surprising finding was that rotation of both AC-PC and hipp line towards x-axis among patients varies up to 35° and the same is true for the skull rotation so that it is not only a matter of the brain position.

No MeSH data available.


Related in: MedlinePlus

Effects of the brains rotations on the area measurements of the hippocampus on the MRI.Three groups are presented on the x-axis – nat (as the unaltered MRI scans were exported for 2D area analysis), hipp (x-axis is parallel to the long axis of the hippocampus) and AC-PC (x axis is parallel to the line connecting anterior and posterior commissure). On the y-axis, 2D area values of the hippocampi in mm2 are presented. Results are presented as median ± min-max.
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pone-0115174-g007: Effects of the brains rotations on the area measurements of the hippocampus on the MRI.Three groups are presented on the x-axis – nat (as the unaltered MRI scans were exported for 2D area analysis), hipp (x-axis is parallel to the long axis of the hippocampus) and AC-PC (x axis is parallel to the line connecting anterior and posterior commissure). On the y-axis, 2D area values of the hippocampi in mm2 are presented. Results are presented as median ± min-max.

Mentions: There was no significant difference between the measured area of hippocampus in nat compared to AC-PC (p = 0.82, W = 0.17). On the other hand, the area of the hippocampus in nat was larger than the area in hipp (p<0.05, W = 0.17). The area of the hippocampus in hipp was smaller compared to the area in AC-PC (p<0.05, W = 0.17) (Fig. 7).


Hippocampal spatial position evaluation on MRI for research and clinical practice.

Mrzílkova J, Koutela A, Kutová M, Patzelt M, Ibrahim I, Al-Kayssi D, Bartoš A, Řípová D, Čermáková P, Zach P - PLoS ONE (2014)

Effects of the brains rotations on the area measurements of the hippocampus on the MRI.Three groups are presented on the x-axis – nat (as the unaltered MRI scans were exported for 2D area analysis), hipp (x-axis is parallel to the long axis of the hippocampus) and AC-PC (x axis is parallel to the line connecting anterior and posterior commissure). On the y-axis, 2D area values of the hippocampi in mm2 are presented. Results are presented as median ± min-max.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4264873&req=5

pone-0115174-g007: Effects of the brains rotations on the area measurements of the hippocampus on the MRI.Three groups are presented on the x-axis – nat (as the unaltered MRI scans were exported for 2D area analysis), hipp (x-axis is parallel to the long axis of the hippocampus) and AC-PC (x axis is parallel to the line connecting anterior and posterior commissure). On the y-axis, 2D area values of the hippocampi in mm2 are presented. Results are presented as median ± min-max.
Mentions: There was no significant difference between the measured area of hippocampus in nat compared to AC-PC (p = 0.82, W = 0.17). On the other hand, the area of the hippocampus in nat was larger than the area in hipp (p<0.05, W = 0.17). The area of the hippocampus in hipp was smaller compared to the area in AC-PC (p<0.05, W = 0.17) (Fig. 7).

Bottom Line: We found that 1) hippocampal area of nat images is larger compared to hipp images, area of the nat images is equal to the AC-PC images and area of the hipp images is smaller compared to AC-PC images, 2) hippocampal area together with the area of the temporal horn for nat images is larger compared to hipp images, area of the hipp images is smaller compared to the AC-PC images and area of the nat images is smaller compared to the AC-PC images.The conclusion is that the measured area of the hippocampus in the native MRI is almost the same as the area of MRI reoriented only into the AC-PC axis.Surprising finding was that rotation of both AC-PC and hipp line towards x-axis among patients varies up to 35° and the same is true for the skull rotation so that it is not only a matter of the brain position.

View Article: PubMed Central - PubMed

Affiliation: Institute of Anatomy, Third Faculty of Medicine, Charles University, Ruská 87, 100 00 Prague 10, Czech Republic.

ABSTRACT
In clinical practice as well as in many volumetric studies we use different reorientations of the brain position towards x and y axis on the magnetic resonance imaging (MRI) scans. In order to find out whether it has an overall effect on the resulting 2D data, manual hippocampal area measurements and rotation variability of the brain (in two reoriented axes) and the skull were performed in 23 Alzheimer's disease patients and 31 healthy controls. After the MRI scanning, native brain scans (nat) were reoriented into the two different artificial planes (anterior commissure-posterior commissure axis (AC-PC) and hippocampal horizontal long axis (hipp)). Hippocampal area and temporal horn of the lateral ventricle was measured manually using freeware Image J program. We found that 1) hippocampal area of nat images is larger compared to hipp images, area of the nat images is equal to the AC-PC images and area of the hipp images is smaller compared to AC-PC images, 2) hippocampal area together with the area of the temporal horn for nat images is larger compared to hipp images, area of the hipp images is smaller compared to the AC-PC images and area of the nat images is smaller compared to the AC-PC images. The conclusion is that the measured area of the hippocampus in the native MRI is almost the same as the area of MRI reoriented only into the AC-PC axis. Therefore, when performing 2D area studies of the hippocampus or in the clinical practice we recommend usage of not-reoriented MRI images or to reorient them into the AC-PC axis. Surprising finding was that rotation of both AC-PC and hipp line towards x-axis among patients varies up to 35° and the same is true for the skull rotation so that it is not only a matter of the brain position.

No MeSH data available.


Related in: MedlinePlus