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Wild blueberries (Vaccinium myrtillus) alleviate inflammation and hypertension associated with developing obesity in mice fed with a high-fat diet.

Mykkänen OT, Huotari A, Herzig KH, Dunlop TW, Mykkänen H, Kirjavainen PV - PLoS ONE (2014)

Bottom Line: Low-grade metabolic inflammation and hypertension are primary mechanisms involved in obesity-associated adverse health effects.This was indicated by the altered cytokine profile and the reduced prevalence of interferon gamma -producing T-cells, in particular T helper type 1 cells.Bilberries reduce the development of systemic inflammation and prevent the progression of chronic hypertension, thus supporting their potential role in alleviating the adverse health effects associated with developing obesity.

View Article: PubMed Central - PubMed

Affiliation: Institute of Public Health and Clinical Nutrition, Department of Clinical Nutrition, Food and Health Research Centre, University of Eastern Finland, Kuopio, Finland.

ABSTRACT

Background: Low-grade metabolic inflammation and hypertension are primary mechanisms involved in obesity-associated adverse health effects. Berries, especially Nordic wild blueberries (hereafter referred to as bilberries), represent an important source of dietary anthocyanins, a group of polyphenols with potential beneficial effects to combat obesity-associated metabolic disturbances.

Methods: The effects of 5% or 10% (w/w) of whole bilberries (BB) were studied on the development of obesity and its metabolic disturbances in C57BL mice fed with a high-fat diet (HFD) for three months. Cytokines, inflammatory cells, systolic blood pressure, glucose tolerance, insulin sensitivity, weight gain, body fat, food consumption and energy metabolism were assessed.

Results: Bilberries ameliorated type 1 pro-inflammatory responsiveness induced by HFD. This was indicated by the altered cytokine profile and the reduced prevalence of interferon gamma -producing T-cells, in particular T helper type 1 cells. Bilberries also prevented the progression of obesity associated long term increase in systolic blood pressure in mice.

Conclusions: Bilberries reduce the development of systemic inflammation and prevent the progression of chronic hypertension, thus supporting their potential role in alleviating the adverse health effects associated with developing obesity.

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Related in: MedlinePlus

Correlations of T helper type 1 cells (Th 1) and serum adiponectin with blood pressure in mice fed NCD, HFD or bilberries in HFD.Correlations of Th1 and serum adiponectin (µg/mL) with blood pressure in mice were analyzed after feeding diets for 12–14 weeks. The relative number of splenic Th 1 cells (CD3+CD4+IFNg+IL4-) of all T cells (CD3+) was used in calculating the correlation. The values of the group fed 10% BB in HFD are highlighted by red circles. Each symbol represents an individual measurement. The lines indicate significant correlations (Spearman's test).
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pone-0114790-g005: Correlations of T helper type 1 cells (Th 1) and serum adiponectin with blood pressure in mice fed NCD, HFD or bilberries in HFD.Correlations of Th1 and serum adiponectin (µg/mL) with blood pressure in mice were analyzed after feeding diets for 12–14 weeks. The relative number of splenic Th 1 cells (CD3+CD4+IFNg+IL4-) of all T cells (CD3+) was used in calculating the correlation. The values of the group fed 10% BB in HFD are highlighted by red circles. Each symbol represents an individual measurement. The lines indicate significant correlations (Spearman's test).

Mentions: The blood pressure was found to correlate with the intake of sodium and levels of pro-inflammatory cytokine IFN-γ and the relative amount of cellular markers of inflammation (Figure S5 and Table S6 in S1 Panel, supporting phenotypic characteristics). The relative amount of several subtypes of T cells correlated positively with blood pressure: i.e. the amounts of Th1 (r = 0.47, p = 0.025), mature NKT cells (r = 0.52, p = 0.011), INF-γ producing cells (r = 0.57, p = 0.004) and Tc cells producing INF-γ (r = 0.60, p = 0.002) were higher in elevated blood pressure (Figure 5 and Figure S5 in S1 Panel, supporting phenotypic characteristics). In addition, blood pressure correlated negatively with the adiponectin level in mice fed with BB and positively in mice fed HFD alone (Figure 5). The adiponectin level correlated also positively with weight for mice fed HFD (0.56, p = 0.038) but not for mice fed BB.


Wild blueberries (Vaccinium myrtillus) alleviate inflammation and hypertension associated with developing obesity in mice fed with a high-fat diet.

Mykkänen OT, Huotari A, Herzig KH, Dunlop TW, Mykkänen H, Kirjavainen PV - PLoS ONE (2014)

Correlations of T helper type 1 cells (Th 1) and serum adiponectin with blood pressure in mice fed NCD, HFD or bilberries in HFD.Correlations of Th1 and serum adiponectin (µg/mL) with blood pressure in mice were analyzed after feeding diets for 12–14 weeks. The relative number of splenic Th 1 cells (CD3+CD4+IFNg+IL4-) of all T cells (CD3+) was used in calculating the correlation. The values of the group fed 10% BB in HFD are highlighted by red circles. Each symbol represents an individual measurement. The lines indicate significant correlations (Spearman's test).
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4264776&req=5

pone-0114790-g005: Correlations of T helper type 1 cells (Th 1) and serum adiponectin with blood pressure in mice fed NCD, HFD or bilberries in HFD.Correlations of Th1 and serum adiponectin (µg/mL) with blood pressure in mice were analyzed after feeding diets for 12–14 weeks. The relative number of splenic Th 1 cells (CD3+CD4+IFNg+IL4-) of all T cells (CD3+) was used in calculating the correlation. The values of the group fed 10% BB in HFD are highlighted by red circles. Each symbol represents an individual measurement. The lines indicate significant correlations (Spearman's test).
Mentions: The blood pressure was found to correlate with the intake of sodium and levels of pro-inflammatory cytokine IFN-γ and the relative amount of cellular markers of inflammation (Figure S5 and Table S6 in S1 Panel, supporting phenotypic characteristics). The relative amount of several subtypes of T cells correlated positively with blood pressure: i.e. the amounts of Th1 (r = 0.47, p = 0.025), mature NKT cells (r = 0.52, p = 0.011), INF-γ producing cells (r = 0.57, p = 0.004) and Tc cells producing INF-γ (r = 0.60, p = 0.002) were higher in elevated blood pressure (Figure 5 and Figure S5 in S1 Panel, supporting phenotypic characteristics). In addition, blood pressure correlated negatively with the adiponectin level in mice fed with BB and positively in mice fed HFD alone (Figure 5). The adiponectin level correlated also positively with weight for mice fed HFD (0.56, p = 0.038) but not for mice fed BB.

Bottom Line: Low-grade metabolic inflammation and hypertension are primary mechanisms involved in obesity-associated adverse health effects.This was indicated by the altered cytokine profile and the reduced prevalence of interferon gamma -producing T-cells, in particular T helper type 1 cells.Bilberries reduce the development of systemic inflammation and prevent the progression of chronic hypertension, thus supporting their potential role in alleviating the adverse health effects associated with developing obesity.

View Article: PubMed Central - PubMed

Affiliation: Institute of Public Health and Clinical Nutrition, Department of Clinical Nutrition, Food and Health Research Centre, University of Eastern Finland, Kuopio, Finland.

ABSTRACT

Background: Low-grade metabolic inflammation and hypertension are primary mechanisms involved in obesity-associated adverse health effects. Berries, especially Nordic wild blueberries (hereafter referred to as bilberries), represent an important source of dietary anthocyanins, a group of polyphenols with potential beneficial effects to combat obesity-associated metabolic disturbances.

Methods: The effects of 5% or 10% (w/w) of whole bilberries (BB) were studied on the development of obesity and its metabolic disturbances in C57BL mice fed with a high-fat diet (HFD) for three months. Cytokines, inflammatory cells, systolic blood pressure, glucose tolerance, insulin sensitivity, weight gain, body fat, food consumption and energy metabolism were assessed.

Results: Bilberries ameliorated type 1 pro-inflammatory responsiveness induced by HFD. This was indicated by the altered cytokine profile and the reduced prevalence of interferon gamma -producing T-cells, in particular T helper type 1 cells. Bilberries also prevented the progression of obesity associated long term increase in systolic blood pressure in mice.

Conclusions: Bilberries reduce the development of systemic inflammation and prevent the progression of chronic hypertension, thus supporting their potential role in alleviating the adverse health effects associated with developing obesity.

Show MeSH
Related in: MedlinePlus