Limits...
Long leukocyte telomere length at diagnosis is a risk factor for dementia progression in idiopathic parkinsonism.

Degerman S, Domellöf M, Landfors M, Linder J, Lundin M, Haraldsson S, Elgh E, Roos G, Forsgren L - PLoS ONE (2014)

Bottom Line: TL and motor and cognitive performance were assessed at baseline (diagnosis) and repeatedly up to three to five years follow up.No difference in TL between controls and patients was shown at baseline, nor any significant difference in TL stability or attrition during follow up.Interestingly, a significant relationship between TL at diagnosis and cognitive phenotype at follow up in PD and PSP patients was found, with longer mean TL at diagnosis in patients that developed dementia within three years.

View Article: PubMed Central - PubMed

Affiliation: Department of Medical Biosciences, Umeå University, Umeå, Sweden.

ABSTRACT
Telomere length (TL) is regarded as a marker of cellular aging due to the gradual shortening by each cell division, but is influenced by a number of factors including oxidative stress and inflammation. Parkinson's disease and atypical forms of parkinsonism occur mainly in the elderly, with oxidative stress and inflammation in afflicted cells. In this study the relationship between blood TL and prognosis of 168 patients with idiopathic parkinsonism (136 Parkinson's disease [PD], 17 Progressive Supranuclear Palsy [PSP], and 15 Multiple System Atrophy [MSA]) and 30 controls was investigated. TL and motor and cognitive performance were assessed at baseline (diagnosis) and repeatedly up to three to five years follow up. No difference in TL between controls and patients was shown at baseline, nor any significant difference in TL stability or attrition during follow up. Interestingly, a significant relationship between TL at diagnosis and cognitive phenotype at follow up in PD and PSP patients was found, with longer mean TL at diagnosis in patients that developed dementia within three years.

Show MeSH

Related in: MedlinePlus

Dementia progression in PD patients with long and short telomeres at diagnosis.Proportion of patients without dementia with long (RTL>0.75) vs. short (RTL≤0.75) leukocyte telomeres using Kaplan-Meier with the log-rank test.
© Copyright Policy
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4264694&req=5

pone-0113387-g004: Dementia progression in PD patients with long and short telomeres at diagnosis.Proportion of patients without dementia with long (RTL>0.75) vs. short (RTL≤0.75) leukocyte telomeres using Kaplan-Meier with the log-rank test.

Mentions: Disease progression monitored as cognitive and motor decline was analyzed in relationship to RTL at diagnosis (S1 Table). In PD and PSP the mean RTL was significantly longer (p = 0.007 and p = 0.037 respectively) in patients who developed dementia within three years from baseline (Fig. 3 A, C). No patient with MSA developed dementia. In contrast, no difference in mean RTL was seen (p = 0.107 (PD), p = 0.271 (PSP), p = 0.397 (MSA)) between patients who during the first three years developed a more sever motor stage (defined as HY stage three or higher) vs those who did not (HY<3) (Fig. 3 B, D and data not shown). Furthermore, RTL at baseline was not related to UPDRS scores (total and motor part III) at three year follow up in any patient group (data not shown). In PD, no difference between men and women regarding dementia progression (p = 0.358, Chi square) was observed. Event free Kaplan Meier survival analysis with progression into dementia defined as event was done, where the PD patients was separated into two RTL groups (short RTL< = 0.75, long RTL>0.75) based on the median RTL value. It showed a significant higher proportion of patients with progression to dementia within three years follow up in patients with long telomeres at baseline (p = 0.035) (Fig. 4).


Long leukocyte telomere length at diagnosis is a risk factor for dementia progression in idiopathic parkinsonism.

Degerman S, Domellöf M, Landfors M, Linder J, Lundin M, Haraldsson S, Elgh E, Roos G, Forsgren L - PLoS ONE (2014)

Dementia progression in PD patients with long and short telomeres at diagnosis.Proportion of patients without dementia with long (RTL>0.75) vs. short (RTL≤0.75) leukocyte telomeres using Kaplan-Meier with the log-rank test.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4264694&req=5

pone-0113387-g004: Dementia progression in PD patients with long and short telomeres at diagnosis.Proportion of patients without dementia with long (RTL>0.75) vs. short (RTL≤0.75) leukocyte telomeres using Kaplan-Meier with the log-rank test.
Mentions: Disease progression monitored as cognitive and motor decline was analyzed in relationship to RTL at diagnosis (S1 Table). In PD and PSP the mean RTL was significantly longer (p = 0.007 and p = 0.037 respectively) in patients who developed dementia within three years from baseline (Fig. 3 A, C). No patient with MSA developed dementia. In contrast, no difference in mean RTL was seen (p = 0.107 (PD), p = 0.271 (PSP), p = 0.397 (MSA)) between patients who during the first three years developed a more sever motor stage (defined as HY stage three or higher) vs those who did not (HY<3) (Fig. 3 B, D and data not shown). Furthermore, RTL at baseline was not related to UPDRS scores (total and motor part III) at three year follow up in any patient group (data not shown). In PD, no difference between men and women regarding dementia progression (p = 0.358, Chi square) was observed. Event free Kaplan Meier survival analysis with progression into dementia defined as event was done, where the PD patients was separated into two RTL groups (short RTL< = 0.75, long RTL>0.75) based on the median RTL value. It showed a significant higher proportion of patients with progression to dementia within three years follow up in patients with long telomeres at baseline (p = 0.035) (Fig. 4).

Bottom Line: TL and motor and cognitive performance were assessed at baseline (diagnosis) and repeatedly up to three to five years follow up.No difference in TL between controls and patients was shown at baseline, nor any significant difference in TL stability or attrition during follow up.Interestingly, a significant relationship between TL at diagnosis and cognitive phenotype at follow up in PD and PSP patients was found, with longer mean TL at diagnosis in patients that developed dementia within three years.

View Article: PubMed Central - PubMed

Affiliation: Department of Medical Biosciences, Umeå University, Umeå, Sweden.

ABSTRACT
Telomere length (TL) is regarded as a marker of cellular aging due to the gradual shortening by each cell division, but is influenced by a number of factors including oxidative stress and inflammation. Parkinson's disease and atypical forms of parkinsonism occur mainly in the elderly, with oxidative stress and inflammation in afflicted cells. In this study the relationship between blood TL and prognosis of 168 patients with idiopathic parkinsonism (136 Parkinson's disease [PD], 17 Progressive Supranuclear Palsy [PSP], and 15 Multiple System Atrophy [MSA]) and 30 controls was investigated. TL and motor and cognitive performance were assessed at baseline (diagnosis) and repeatedly up to three to five years follow up. No difference in TL between controls and patients was shown at baseline, nor any significant difference in TL stability or attrition during follow up. Interestingly, a significant relationship between TL at diagnosis and cognitive phenotype at follow up in PD and PSP patients was found, with longer mean TL at diagnosis in patients that developed dementia within three years.

Show MeSH
Related in: MedlinePlus