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Long leukocyte telomere length at diagnosis is a risk factor for dementia progression in idiopathic parkinsonism.

Degerman S, Domellöf M, Landfors M, Linder J, Lundin M, Haraldsson S, Elgh E, Roos G, Forsgren L - PLoS ONE (2014)

Bottom Line: TL and motor and cognitive performance were assessed at baseline (diagnosis) and repeatedly up to three to five years follow up.No difference in TL between controls and patients was shown at baseline, nor any significant difference in TL stability or attrition during follow up.Interestingly, a significant relationship between TL at diagnosis and cognitive phenotype at follow up in PD and PSP patients was found, with longer mean TL at diagnosis in patients that developed dementia within three years.

View Article: PubMed Central - PubMed

Affiliation: Department of Medical Biosciences, Umeå University, Umeå, Sweden.

ABSTRACT
Telomere length (TL) is regarded as a marker of cellular aging due to the gradual shortening by each cell division, but is influenced by a number of factors including oxidative stress and inflammation. Parkinson's disease and atypical forms of parkinsonism occur mainly in the elderly, with oxidative stress and inflammation in afflicted cells. In this study the relationship between blood TL and prognosis of 168 patients with idiopathic parkinsonism (136 Parkinson's disease [PD], 17 Progressive Supranuclear Palsy [PSP], and 15 Multiple System Atrophy [MSA]) and 30 controls was investigated. TL and motor and cognitive performance were assessed at baseline (diagnosis) and repeatedly up to three to five years follow up. No difference in TL between controls and patients was shown at baseline, nor any significant difference in TL stability or attrition during follow up. Interestingly, a significant relationship between TL at diagnosis and cognitive phenotype at follow up in PD and PSP patients was found, with longer mean TL at diagnosis in patients that developed dementia within three years.

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Related in: MedlinePlus

Telomere length dynamics.A) Individual relative telomere length (RTL) at diagnosis and at repeated follow up for up to five years in control, PD, PSP and MSA groups. RTL quartiles marked in each individual. B–C) Std.Dev (B) and CV% (C) of RTL in control, PD, PSP and MSA groups from baseline and up to five years follow up. D–E) Individuals RTL change between baseline and three year follow up in control (D) and PD (E).
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pone-0113387-g002: Telomere length dynamics.A) Individual relative telomere length (RTL) at diagnosis and at repeated follow up for up to five years in control, PD, PSP and MSA groups. RTL quartiles marked in each individual. B–C) Std.Dev (B) and CV% (C) of RTL in control, PD, PSP and MSA groups from baseline and up to five years follow up. D–E) Individuals RTL change between baseline and three year follow up in control (D) and PD (E).

Mentions: The overview of telomere length dynamics in control, PD, PSP and MSA individuals at baseline and up to five years follow up showed a wide span in RTL between individuals (Fig. 2A). However, individual's telomere length seems rather stable over time in all groups (Fig. 2A). Telomere length variation over time was tested and no significant differences in std.dev or CV (%) (baseline and up to five year follow up) was observed in the control, PD, PSP or MSA groups (Fig. 2B–C).


Long leukocyte telomere length at diagnosis is a risk factor for dementia progression in idiopathic parkinsonism.

Degerman S, Domellöf M, Landfors M, Linder J, Lundin M, Haraldsson S, Elgh E, Roos G, Forsgren L - PLoS ONE (2014)

Telomere length dynamics.A) Individual relative telomere length (RTL) at diagnosis and at repeated follow up for up to five years in control, PD, PSP and MSA groups. RTL quartiles marked in each individual. B–C) Std.Dev (B) and CV% (C) of RTL in control, PD, PSP and MSA groups from baseline and up to five years follow up. D–E) Individuals RTL change between baseline and three year follow up in control (D) and PD (E).
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4264694&req=5

pone-0113387-g002: Telomere length dynamics.A) Individual relative telomere length (RTL) at diagnosis and at repeated follow up for up to five years in control, PD, PSP and MSA groups. RTL quartiles marked in each individual. B–C) Std.Dev (B) and CV% (C) of RTL in control, PD, PSP and MSA groups from baseline and up to five years follow up. D–E) Individuals RTL change between baseline and three year follow up in control (D) and PD (E).
Mentions: The overview of telomere length dynamics in control, PD, PSP and MSA individuals at baseline and up to five years follow up showed a wide span in RTL between individuals (Fig. 2A). However, individual's telomere length seems rather stable over time in all groups (Fig. 2A). Telomere length variation over time was tested and no significant differences in std.dev or CV (%) (baseline and up to five year follow up) was observed in the control, PD, PSP or MSA groups (Fig. 2B–C).

Bottom Line: TL and motor and cognitive performance were assessed at baseline (diagnosis) and repeatedly up to three to five years follow up.No difference in TL between controls and patients was shown at baseline, nor any significant difference in TL stability or attrition during follow up.Interestingly, a significant relationship between TL at diagnosis and cognitive phenotype at follow up in PD and PSP patients was found, with longer mean TL at diagnosis in patients that developed dementia within three years.

View Article: PubMed Central - PubMed

Affiliation: Department of Medical Biosciences, Umeå University, Umeå, Sweden.

ABSTRACT
Telomere length (TL) is regarded as a marker of cellular aging due to the gradual shortening by each cell division, but is influenced by a number of factors including oxidative stress and inflammation. Parkinson's disease and atypical forms of parkinsonism occur mainly in the elderly, with oxidative stress and inflammation in afflicted cells. In this study the relationship between blood TL and prognosis of 168 patients with idiopathic parkinsonism (136 Parkinson's disease [PD], 17 Progressive Supranuclear Palsy [PSP], and 15 Multiple System Atrophy [MSA]) and 30 controls was investigated. TL and motor and cognitive performance were assessed at baseline (diagnosis) and repeatedly up to three to five years follow up. No difference in TL between controls and patients was shown at baseline, nor any significant difference in TL stability or attrition during follow up. Interestingly, a significant relationship between TL at diagnosis and cognitive phenotype at follow up in PD and PSP patients was found, with longer mean TL at diagnosis in patients that developed dementia within three years.

Show MeSH
Related in: MedlinePlus