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The effectiveness of convalescent plasma and hyperimmune immunoglobulin for the treatment of severe acute respiratory infections of viral etiology: a systematic review and exploratory meta-analysis.

Mair-Jenkins J, Saavedra-Campos M, Baillie JK, Cleary P, Khaw FM, Lim WS, Makki S, Rooney KD, Beck CR, Convalescent Plasma Study Gro - J. Infect. Dis. (2014)

Bottom Line: Narrative analyses revealed consistent evidence for a reduction in mortality, especially when convalescent plasma is administered early after symptom onset.Exploratory post hoc meta-analysis showed a statistically significant reduction in the pooled odds of mortality following treatment, compared with placebo or no therapy (odds ratio, 0.25; 95% confidence interval, .14-.45; I(2) = 0%).Convalescent plasma may reduce mortality and appears safe.

View Article: PubMed Central - PubMed

Affiliation: East Midlands Centre, Public Health England.

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Related in: MedlinePlus

Forest plot of pooled odds ratios (ORs) of mortality following treatment with convalescent plasma or convalescent serum (n = 8 studies). Weights are from random-effects analysis. Abbreviation: CI, confidence interval.
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JIU396F3: Forest plot of pooled odds ratios (ORs) of mortality following treatment with convalescent plasma or convalescent serum (n = 8 studies). Weights are from random-effects analysis. Abbreviation: CI, confidence interval.

Mentions: The post hoc meta-analysis evaluated pooled data from 8 comparative studies: 2 studies of SARS-CoV infection [32, 46], 2 of influenza A(H1N1)pdm09 infection [30, 48], 1 of avian influenza A(H5N1) infection [36], and 3 of Spanish influenza A(H1N1) infection [33, 38, 47]. There was a statistically significance lower risk of mortality in the group treated with convalescent plasma or serum (pooled OR, 0.25; 95% CI, .14 to .45; P < .001; I2 = 0%; Figure 3). Examination of the funnel plot and findings of the Egger test showed no evidence of publication bias. Sensitivity analyses that excluded studies with ≤5 cases demonstrated little variation in the pooled OR or change in statistical heterogeneity (Figure 4).Figure 3.


The effectiveness of convalescent plasma and hyperimmune immunoglobulin for the treatment of severe acute respiratory infections of viral etiology: a systematic review and exploratory meta-analysis.

Mair-Jenkins J, Saavedra-Campos M, Baillie JK, Cleary P, Khaw FM, Lim WS, Makki S, Rooney KD, Beck CR, Convalescent Plasma Study Gro - J. Infect. Dis. (2014)

Forest plot of pooled odds ratios (ORs) of mortality following treatment with convalescent plasma or convalescent serum (n = 8 studies). Weights are from random-effects analysis. Abbreviation: CI, confidence interval.
© Copyright Policy - creative-commons
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4264590&req=5

JIU396F3: Forest plot of pooled odds ratios (ORs) of mortality following treatment with convalescent plasma or convalescent serum (n = 8 studies). Weights are from random-effects analysis. Abbreviation: CI, confidence interval.
Mentions: The post hoc meta-analysis evaluated pooled data from 8 comparative studies: 2 studies of SARS-CoV infection [32, 46], 2 of influenza A(H1N1)pdm09 infection [30, 48], 1 of avian influenza A(H5N1) infection [36], and 3 of Spanish influenza A(H1N1) infection [33, 38, 47]. There was a statistically significance lower risk of mortality in the group treated with convalescent plasma or serum (pooled OR, 0.25; 95% CI, .14 to .45; P < .001; I2 = 0%; Figure 3). Examination of the funnel plot and findings of the Egger test showed no evidence of publication bias. Sensitivity analyses that excluded studies with ≤5 cases demonstrated little variation in the pooled OR or change in statistical heterogeneity (Figure 4).Figure 3.

Bottom Line: Narrative analyses revealed consistent evidence for a reduction in mortality, especially when convalescent plasma is administered early after symptom onset.Exploratory post hoc meta-analysis showed a statistically significant reduction in the pooled odds of mortality following treatment, compared with placebo or no therapy (odds ratio, 0.25; 95% confidence interval, .14-.45; I(2) = 0%).Convalescent plasma may reduce mortality and appears safe.

View Article: PubMed Central - PubMed

Affiliation: East Midlands Centre, Public Health England.

Show MeSH
Related in: MedlinePlus