The effectiveness of convalescent plasma and hyperimmune immunoglobulin for the treatment of severe acute respiratory infections of viral etiology: a systematic review and exploratory meta-analysis.
Bottom Line: Narrative analyses revealed consistent evidence for a reduction in mortality, especially when convalescent plasma is administered early after symptom onset.Exploratory post hoc meta-analysis showed a statistically significant reduction in the pooled odds of mortality following treatment, compared with placebo or no therapy (odds ratio, 0.25; 95% confidence interval, .14-.45; I(2) = 0%).Convalescent plasma may reduce mortality and appears safe.
Affiliation: East Midlands Centre, Public Health England.Show MeSH
Related in: MedlinePlus
Mentions: The search process yielded 3406 records (Figure 1). After sifting 1449 unique records against the protocol eligibility criteria, we identified 32 studies from 50 reports (Supplementary Table 1). Three studies could not be obtained [17–19], although results from a study by Bass et al  were reported elsewhere , which enabled their inclusion. French (n = 1), German (n = 2), and Korean (n = 2) records were screened by single reviewers because of a lack of multilingual collaborators.Figure 1.