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Standardization of Rajanyādi cūrṇa: An ayurvedic preparation.

Deshpande R, Shreedhara CS, Setty Aswatha Ram HH - Anc Sci Life (2014)

Bottom Line: The cūrṇa was prepared in-house in three different batches according to directions given in The Ayurvedic Formulary of India.The parameters were found to be comparable and sufficient for the evaluation of the cūrṇa.Ayurvedic medicine, RC has been standardized using the various parameters and can be incorporated while developing the pharmacopoeial standards.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmacognosy, Manipal College of Pharmaceutical Sciences, Manipal University, Manipal, Karnataka, India.

ABSTRACT

Background: Rajanyādi cūrṇa (RC) is an ayurvedic classical preparation used in the treatment of digestive disorders, fever, jaundice, anemia, and asthma. We seek to standardize this drug to ensure its quality.

Objective: The current investigation was aimed at the preparation of cūrṇa in three batches so as to standardize it.

Materials and methods: The cūrṇa was prepared in-house in three different batches according to directions given in The Ayurvedic Formulary of India. The cūrṇa was evaluated based on organoleptic characters, physical characteristics, and physico-chemical parameters. High performance thin layer chromatography was carried out for the quantification of curcumin.

Results: The parameters were found to be comparable and sufficient for the evaluation of the cūrṇa.

Conclusion: Ayurvedic medicine, RC has been standardized using the various parameters and can be incorporated while developing the pharmacopoeial standards.

No MeSH data available.


Related in: MedlinePlus

Chromatogram of Rajanyādi cūrṇa alcoholic
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Figure 5: Chromatogram of Rajanyādi cūrṇa alcoholic

Mentions: In the present study, curcumin has been determined by HPTLC method and it was used as marker compound.[15] Curcumin, a yellow pigment present in Curcuma longa has been linked with various biological activities such as suppression of inflammation; angiogenesis; tumorigenesis; diabetes; diseases of the cardiovascular, pulmonary, and neurological systems, of skin, and of liver; loss of bone and muscle; depression; chronic fatigue; and neuropathic pain.[21] Due to the shortage and lack of availability of markers including the purity, HPTLC determination of all the ingredients was not possible except for curcumin. The chromatographic system afforded a satisfactory Rf value of 0.69 for curcumin of test extract which was comparable with the standard. The curcumin content of the RCAL was found to be 0.335% w/w. The video densitometry of the developed plate is shown in Figure 3. Curcumin[22] (may be actually mixture of three curcuminoids) has therefore shown three spots. The chromatogram of standard curcumin and RCAL is shown in the Figures 4 and 5 respectively. From the above results, Analytical specifications for RC have been represented in Table 4.


Standardization of Rajanyādi cūrṇa: An ayurvedic preparation.

Deshpande R, Shreedhara CS, Setty Aswatha Ram HH - Anc Sci Life (2014)

Chromatogram of Rajanyādi cūrṇa alcoholic
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4264301&req=5

Figure 5: Chromatogram of Rajanyādi cūrṇa alcoholic
Mentions: In the present study, curcumin has been determined by HPTLC method and it was used as marker compound.[15] Curcumin, a yellow pigment present in Curcuma longa has been linked with various biological activities such as suppression of inflammation; angiogenesis; tumorigenesis; diabetes; diseases of the cardiovascular, pulmonary, and neurological systems, of skin, and of liver; loss of bone and muscle; depression; chronic fatigue; and neuropathic pain.[21] Due to the shortage and lack of availability of markers including the purity, HPTLC determination of all the ingredients was not possible except for curcumin. The chromatographic system afforded a satisfactory Rf value of 0.69 for curcumin of test extract which was comparable with the standard. The curcumin content of the RCAL was found to be 0.335% w/w. The video densitometry of the developed plate is shown in Figure 3. Curcumin[22] (may be actually mixture of three curcuminoids) has therefore shown three spots. The chromatogram of standard curcumin and RCAL is shown in the Figures 4 and 5 respectively. From the above results, Analytical specifications for RC have been represented in Table 4.

Bottom Line: The cūrṇa was prepared in-house in three different batches according to directions given in The Ayurvedic Formulary of India.The parameters were found to be comparable and sufficient for the evaluation of the cūrṇa.Ayurvedic medicine, RC has been standardized using the various parameters and can be incorporated while developing the pharmacopoeial standards.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmacognosy, Manipal College of Pharmaceutical Sciences, Manipal University, Manipal, Karnataka, India.

ABSTRACT

Background: Rajanyādi cūrṇa (RC) is an ayurvedic classical preparation used in the treatment of digestive disorders, fever, jaundice, anemia, and asthma. We seek to standardize this drug to ensure its quality.

Objective: The current investigation was aimed at the preparation of cūrṇa in three batches so as to standardize it.

Materials and methods: The cūrṇa was prepared in-house in three different batches according to directions given in The Ayurvedic Formulary of India. The cūrṇa was evaluated based on organoleptic characters, physical characteristics, and physico-chemical parameters. High performance thin layer chromatography was carried out for the quantification of curcumin.

Results: The parameters were found to be comparable and sufficient for the evaluation of the cūrṇa.

Conclusion: Ayurvedic medicine, RC has been standardized using the various parameters and can be incorporated while developing the pharmacopoeial standards.

No MeSH data available.


Related in: MedlinePlus