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The Risk of Coronary Heart Disease in Patients with Kidney Stones: A Systematic Review and Meta-analysis.

Cheungpasitporn W, Thongprayoon C, Mao MA, O'Corragain OA, Edmonds PJ, Erickson SB - N Am J Med Sci (2014)

Bottom Line: Seven study populations from four cohort studies and one cross-sectional study were identified and included in the data analysis.This result remained significant (RR, 1.23 [95% CI, 1.08-1.41]) when the sensitivity analysis was restricted to only cohort studies.A history of kidney stones was associated with increased CHD risk in females (RR, 1.43 [95% CI, 1.12-1.82]), whereas the association was not significant in males (RR, 1.14 [95% CI, 0.94-1.38]).

View Article: PubMed Central - PubMed

Affiliation: Division of Nephrology and Hypertension, Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota, USA.

ABSTRACT

Background: The reported risk of coronary heart disease (CHD) in patients with a history of kidney stones is conflicting.

Aims: The objective of this meta-analysis was to assess the association between a history of kidney stones and CHD risk.

Materials and methods: A literature search was performed using MEDLINE, EMBASE, and Cochrane Database of Systematic Reviews from inception until April 04, 2014. Studies that reported odds ratios or hazard ratios comparing the risk of CHD in patients with a history of kidney stones versus those without a history of kidney stones were included. Pooled risk ratios (RRs) and 95% confidence interval (CI) were calculated using a random-effect, generic inverse variance method.

Results: Seven study populations from four cohort studies and one cross-sectional study were identified and included in the data analysis. The pooled risk ratio (RR) of CHD in patients with kidney stones was 1.24 (95% CI, 1.10-1.40). This result remained significant (RR, 1.23 [95% CI, 1.08-1.41]) when the sensitivity analysis was restricted to only cohort studies. A history of kidney stones was associated with increased CHD risk in females (RR, 1.43 [95% CI, 1.12-1.82]), whereas the association was not significant in males (RR, 1.14 [95% CI, 0.94-1.38]).

Conclusions: Our study demonstrates a statistically significant increased risk of CHD in female patients with prior kidney stones. This finding suggests that a history of kidney stones is a risk factor for CHD in females and may impact clinical management.

No MeSH data available.


Related in: MedlinePlus

Forest plot of the included studies comparing risk of CHD between patients with a history of kidney stones and those without a history of kidney stones
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Figure 1: Forest plot of the included studies comparing risk of CHD between patients with a history of kidney stones and those without a history of kidney stones

Mentions: The pooled risk ratio (RR) of CHD of subjects with kidney stones versus control subjects was 1.24 (95% CI, 1.10-1.40). The statistical heterogeneity was high with an I2 of 84%. Figure 1 demonstrates the forest plot of the included studies. In addition, a history of kidney stones was associated with increased CHD risk in females (RR, 1.43 [95% CI, 1.12-1.82], I2, 88%), whereas the association was not significant in males (RR, 1.14 [95% CI, 0.94-1.38], I2, 87%). Figure 2 and Figure 3 show the forest plot of the included studies in females and males with kidney stones, respectively.


The Risk of Coronary Heart Disease in Patients with Kidney Stones: A Systematic Review and Meta-analysis.

Cheungpasitporn W, Thongprayoon C, Mao MA, O'Corragain OA, Edmonds PJ, Erickson SB - N Am J Med Sci (2014)

Forest plot of the included studies comparing risk of CHD between patients with a history of kidney stones and those without a history of kidney stones
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4264294&req=5

Figure 1: Forest plot of the included studies comparing risk of CHD between patients with a history of kidney stones and those without a history of kidney stones
Mentions: The pooled risk ratio (RR) of CHD of subjects with kidney stones versus control subjects was 1.24 (95% CI, 1.10-1.40). The statistical heterogeneity was high with an I2 of 84%. Figure 1 demonstrates the forest plot of the included studies. In addition, a history of kidney stones was associated with increased CHD risk in females (RR, 1.43 [95% CI, 1.12-1.82], I2, 88%), whereas the association was not significant in males (RR, 1.14 [95% CI, 0.94-1.38], I2, 87%). Figure 2 and Figure 3 show the forest plot of the included studies in females and males with kidney stones, respectively.

Bottom Line: Seven study populations from four cohort studies and one cross-sectional study were identified and included in the data analysis.This result remained significant (RR, 1.23 [95% CI, 1.08-1.41]) when the sensitivity analysis was restricted to only cohort studies.A history of kidney stones was associated with increased CHD risk in females (RR, 1.43 [95% CI, 1.12-1.82]), whereas the association was not significant in males (RR, 1.14 [95% CI, 0.94-1.38]).

View Article: PubMed Central - PubMed

Affiliation: Division of Nephrology and Hypertension, Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota, USA.

ABSTRACT

Background: The reported risk of coronary heart disease (CHD) in patients with a history of kidney stones is conflicting.

Aims: The objective of this meta-analysis was to assess the association between a history of kidney stones and CHD risk.

Materials and methods: A literature search was performed using MEDLINE, EMBASE, and Cochrane Database of Systematic Reviews from inception until April 04, 2014. Studies that reported odds ratios or hazard ratios comparing the risk of CHD in patients with a history of kidney stones versus those without a history of kidney stones were included. Pooled risk ratios (RRs) and 95% confidence interval (CI) were calculated using a random-effect, generic inverse variance method.

Results: Seven study populations from four cohort studies and one cross-sectional study were identified and included in the data analysis. The pooled risk ratio (RR) of CHD in patients with kidney stones was 1.24 (95% CI, 1.10-1.40). This result remained significant (RR, 1.23 [95% CI, 1.08-1.41]) when the sensitivity analysis was restricted to only cohort studies. A history of kidney stones was associated with increased CHD risk in females (RR, 1.43 [95% CI, 1.12-1.82]), whereas the association was not significant in males (RR, 1.14 [95% CI, 0.94-1.38]).

Conclusions: Our study demonstrates a statistically significant increased risk of CHD in female patients with prior kidney stones. This finding suggests that a history of kidney stones is a risk factor for CHD in females and may impact clinical management.

No MeSH data available.


Related in: MedlinePlus