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Hepatoma-derived growth factor upregulation is correlated with prognostic factors of early-stage cervical adenocarcinoma.

Tsai CC, Huang SC, Tai MH, Chien CC, Huang CC, Hsu YC - Int J Mol Sci (2014)

Bottom Line: The expression of HDGF was significantly increased compared with adjacent non-tumor tissue samples (p < 0.001).The HDGF mRNA and protein level were significantly higher in malignant cervical cancer cells compared with primary ones.Cytoplasmic HDGF expression is strongly correlated with pelvic lymph node metastasis and recurrence, indicating that HDGF may serve as a novel prognostic marker for patients with Cx.

View Article: PubMed Central - PubMed

Affiliation: Department of Obstetrics and Gynecology, Chang Gung Memorial Hospital, Kaohsiung and College of Medicine, Chang Gung University, Kaohsiung 83301, Taiwan. nick@cgmh.org.tw.

ABSTRACT
Hepatoma-derived growth factor (HDGF) is a unique nuclear/growth factor that plays an important role in the progression of different types of cancer. A total of 63 patients with early-stage cervical adenocarcinoma (Cx) were enrolled in this retrospective study. The expression of HDGF was significantly increased compared with adjacent non-tumor tissue samples (p < 0.001). Moreover, elevated nuclear HDGF levels were correlated with lymph-vascular space invasion (LVSI; p < 0.05), lymph node metastasis (LNM; p < 0.001), recurrence (p < 0.001) and advanced grade (AG; p < 0.001). The growth of cervical cancer cells (Hela cells) was enhanced by HDGF treatment. The HDGF mRNA and protein level were significantly higher in malignant cervical cancer cells compared with primary ones. By adenovirus gene delivery, HDGF overexpression enhanced, whereas HDGF knockdown perturbed the tumorigenic behaviors of cervical cancer cells. HDGF overexpression is common in early-stage cervical adenocarcinoma and is involved in the carcinogenesis of cervical adenocarcinoma. Cytoplasmic HDGF expression is strongly correlated with pelvic lymph node metastasis and recurrence, indicating that HDGF may serve as a novel prognostic marker for patients with Cx.

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Kaplan-Meier analysis of overall survival rates for patients with cervical adenocarcinoma (Cx) exhibiting different subcellular HDGF expression levels. Correlation between cytoplasmic HDGF and overall survival. Patients with a lower expression of cytoplasmic HDGF had significantly more favorable survival rates compared with the patients with higher expression of cytoplasmic HDGF (p= 0.001). The correlation between nuclear HDGF and overall survival: patients with a lower expression of nuclear HDGF had better overall survival results than the patients with a higher expression of HDGF (p = 0.014).
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ijms-15-21492-f002: Kaplan-Meier analysis of overall survival rates for patients with cervical adenocarcinoma (Cx) exhibiting different subcellular HDGF expression levels. Correlation between cytoplasmic HDGF and overall survival. Patients with a lower expression of cytoplasmic HDGF had significantly more favorable survival rates compared with the patients with higher expression of cytoplasmic HDGF (p= 0.001). The correlation between nuclear HDGF and overall survival: patients with a lower expression of nuclear HDGF had better overall survival results than the patients with a higher expression of HDGF (p = 0.014).

Mentions: Kaplan-Meier analysis revealed that the patients with Cx specimens exhibiting low nuclear and cytoplasmic expressions of HDGF had favorable overall survival results; the 1- to 120-month overall survival rates for these patients are shown in Figure 2. Furthermore, the patients with Cx specimens exhibiting low cytoplasmic expressions of HDGF also had a significantly longer disease-free survival. The 1-, 5- and 10-year overall survival rates were 90%, 80% and 80%, respectively, compared to 95%, 65% and 40%, respectively, for the patients with Cx specimens exhibiting high cytoplasmic HDGF (Figure 2). Similarly, the patients with Cx specimens exhibiting lower nuclear expressions of HDGF had better overall survival results.


Hepatoma-derived growth factor upregulation is correlated with prognostic factors of early-stage cervical adenocarcinoma.

Tsai CC, Huang SC, Tai MH, Chien CC, Huang CC, Hsu YC - Int J Mol Sci (2014)

Kaplan-Meier analysis of overall survival rates for patients with cervical adenocarcinoma (Cx) exhibiting different subcellular HDGF expression levels. Correlation between cytoplasmic HDGF and overall survival. Patients with a lower expression of cytoplasmic HDGF had significantly more favorable survival rates compared with the patients with higher expression of cytoplasmic HDGF (p= 0.001). The correlation between nuclear HDGF and overall survival: patients with a lower expression of nuclear HDGF had better overall survival results than the patients with a higher expression of HDGF (p = 0.014).
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4264238&req=5

ijms-15-21492-f002: Kaplan-Meier analysis of overall survival rates for patients with cervical adenocarcinoma (Cx) exhibiting different subcellular HDGF expression levels. Correlation between cytoplasmic HDGF and overall survival. Patients with a lower expression of cytoplasmic HDGF had significantly more favorable survival rates compared with the patients with higher expression of cytoplasmic HDGF (p= 0.001). The correlation between nuclear HDGF and overall survival: patients with a lower expression of nuclear HDGF had better overall survival results than the patients with a higher expression of HDGF (p = 0.014).
Mentions: Kaplan-Meier analysis revealed that the patients with Cx specimens exhibiting low nuclear and cytoplasmic expressions of HDGF had favorable overall survival results; the 1- to 120-month overall survival rates for these patients are shown in Figure 2. Furthermore, the patients with Cx specimens exhibiting low cytoplasmic expressions of HDGF also had a significantly longer disease-free survival. The 1-, 5- and 10-year overall survival rates were 90%, 80% and 80%, respectively, compared to 95%, 65% and 40%, respectively, for the patients with Cx specimens exhibiting high cytoplasmic HDGF (Figure 2). Similarly, the patients with Cx specimens exhibiting lower nuclear expressions of HDGF had better overall survival results.

Bottom Line: The expression of HDGF was significantly increased compared with adjacent non-tumor tissue samples (p < 0.001).The HDGF mRNA and protein level were significantly higher in malignant cervical cancer cells compared with primary ones.Cytoplasmic HDGF expression is strongly correlated with pelvic lymph node metastasis and recurrence, indicating that HDGF may serve as a novel prognostic marker for patients with Cx.

View Article: PubMed Central - PubMed

Affiliation: Department of Obstetrics and Gynecology, Chang Gung Memorial Hospital, Kaohsiung and College of Medicine, Chang Gung University, Kaohsiung 83301, Taiwan. nick@cgmh.org.tw.

ABSTRACT
Hepatoma-derived growth factor (HDGF) is a unique nuclear/growth factor that plays an important role in the progression of different types of cancer. A total of 63 patients with early-stage cervical adenocarcinoma (Cx) were enrolled in this retrospective study. The expression of HDGF was significantly increased compared with adjacent non-tumor tissue samples (p < 0.001). Moreover, elevated nuclear HDGF levels were correlated with lymph-vascular space invasion (LVSI; p < 0.05), lymph node metastasis (LNM; p < 0.001), recurrence (p < 0.001) and advanced grade (AG; p < 0.001). The growth of cervical cancer cells (Hela cells) was enhanced by HDGF treatment. The HDGF mRNA and protein level were significantly higher in malignant cervical cancer cells compared with primary ones. By adenovirus gene delivery, HDGF overexpression enhanced, whereas HDGF knockdown perturbed the tumorigenic behaviors of cervical cancer cells. HDGF overexpression is common in early-stage cervical adenocarcinoma and is involved in the carcinogenesis of cervical adenocarcinoma. Cytoplasmic HDGF expression is strongly correlated with pelvic lymph node metastasis and recurrence, indicating that HDGF may serve as a novel prognostic marker for patients with Cx.

Show MeSH
Related in: MedlinePlus