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HIV and hepatitis C mortality in Massachusetts, 2002-2011: spatial cluster and trend analysis of HIV and HCV using multiple cause of death.

Meyers DJ, Hood ME, Stopka TJ - PLoS ONE (2014)

Bottom Line: The most significant clusters occurred in Springfield, Worcester, South Boston, the Merrimack Valley, and New Bedford with other smaller clusters detected across the state.Multiple cause of death mortality rates were much higher than underlying cause mortality alone, and significant disparities existed across race and age groups.We found that our multi-method analyses, which focused on contributing causes of death, were more robust than analyses that focused on underlying cause of death alone.

View Article: PubMed Central - PubMed

Affiliation: Department of Health Policy and Management, Harvard School of Public Health, Boston, Massachusetts, United States of America; Department of Public Health and Community Medicine, Tufts University School of Medicine, Boston, Massachusetts, United States of America.

ABSTRACT

Background: Infectious diseases, while associated with a much smaller proportion of deaths than they were 50 years ago, still play a significant role in mortality across the state of Massachusetts. Most analysis of infectious disease mortality in the state only take into account the underlying cause of death, rather than contributing causes of death, which may not capture the full extent of mortality trends for infectious diseases such as HIV and the Hepatitis C virus (HCV).

Methods: In this study we sought to evaluate current trends in infectious disease mortality across the state using a multiple cause of death methodology. We performed a mortality trend analysis, identified spatial clusters of disease using a 5-step geoprocessing approach and examined spatial-temporal clustering trends in infectious disease mortality in Massachusetts from 2002-2011, with a focus on HIV/AIDS and HCV.

Results: Significant clusters of high infectious disease mortality in space and time throughout the state were detected through both spatial and space time cluster analysis. The most significant clusters occurred in Springfield, Worcester, South Boston, the Merrimack Valley, and New Bedford with other smaller clusters detected across the state. Multiple cause of death mortality rates were much higher than underlying cause mortality alone, and significant disparities existed across race and age groups.

Conclusions: We found that our multi-method analyses, which focused on contributing causes of death, were more robust than analyses that focused on underlying cause of death alone. Our results may be used to inform public health resource allocation for infectious disease prevention and treatment programs, provide novel insight into the current state of infectious disease mortality throughout the state, and benefited from approaches that may more accurately document mortality trends.

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Related in: MedlinePlus

Standardized HCV and HIV Mortality Rates by Race in MA between 2002–2011.Panel A is Hepatitis C. Panel B is HIV/AIDS.
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pone-0114822-g003: Standardized HCV and HIV Mortality Rates by Race in MA between 2002–2011.Panel A is Hepatitis C. Panel B is HIV/AIDS.

Mentions: Fig. 3, Panels A and B display standardized age-adjusted mortality rates per 100,000 people for HCV and HIV/AIDS respectively by race and Hispanic ethnicity. Each graph also includes error bars that illustrate the 95% confidence interval of the overall mortality rate, which included contributing and underlying cause of death. For both diseases, there exists a similar disparity in the mortality rates between White and Asian populations and Black and Hispanic populations, which had significantly higher rates. Death rates among Blacks and Hispanics are significantly higher than those of White and Asian populations for HIV/AIDS and HCV.


HIV and hepatitis C mortality in Massachusetts, 2002-2011: spatial cluster and trend analysis of HIV and HCV using multiple cause of death.

Meyers DJ, Hood ME, Stopka TJ - PLoS ONE (2014)

Standardized HCV and HIV Mortality Rates by Race in MA between 2002–2011.Panel A is Hepatitis C. Panel B is HIV/AIDS.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4263669&req=5

pone-0114822-g003: Standardized HCV and HIV Mortality Rates by Race in MA between 2002–2011.Panel A is Hepatitis C. Panel B is HIV/AIDS.
Mentions: Fig. 3, Panels A and B display standardized age-adjusted mortality rates per 100,000 people for HCV and HIV/AIDS respectively by race and Hispanic ethnicity. Each graph also includes error bars that illustrate the 95% confidence interval of the overall mortality rate, which included contributing and underlying cause of death. For both diseases, there exists a similar disparity in the mortality rates between White and Asian populations and Black and Hispanic populations, which had significantly higher rates. Death rates among Blacks and Hispanics are significantly higher than those of White and Asian populations for HIV/AIDS and HCV.

Bottom Line: The most significant clusters occurred in Springfield, Worcester, South Boston, the Merrimack Valley, and New Bedford with other smaller clusters detected across the state.Multiple cause of death mortality rates were much higher than underlying cause mortality alone, and significant disparities existed across race and age groups.We found that our multi-method analyses, which focused on contributing causes of death, were more robust than analyses that focused on underlying cause of death alone.

View Article: PubMed Central - PubMed

Affiliation: Department of Health Policy and Management, Harvard School of Public Health, Boston, Massachusetts, United States of America; Department of Public Health and Community Medicine, Tufts University School of Medicine, Boston, Massachusetts, United States of America.

ABSTRACT

Background: Infectious diseases, while associated with a much smaller proportion of deaths than they were 50 years ago, still play a significant role in mortality across the state of Massachusetts. Most analysis of infectious disease mortality in the state only take into account the underlying cause of death, rather than contributing causes of death, which may not capture the full extent of mortality trends for infectious diseases such as HIV and the Hepatitis C virus (HCV).

Methods: In this study we sought to evaluate current trends in infectious disease mortality across the state using a multiple cause of death methodology. We performed a mortality trend analysis, identified spatial clusters of disease using a 5-step geoprocessing approach and examined spatial-temporal clustering trends in infectious disease mortality in Massachusetts from 2002-2011, with a focus on HIV/AIDS and HCV.

Results: Significant clusters of high infectious disease mortality in space and time throughout the state were detected through both spatial and space time cluster analysis. The most significant clusters occurred in Springfield, Worcester, South Boston, the Merrimack Valley, and New Bedford with other smaller clusters detected across the state. Multiple cause of death mortality rates were much higher than underlying cause mortality alone, and significant disparities existed across race and age groups.

Conclusions: We found that our multi-method analyses, which focused on contributing causes of death, were more robust than analyses that focused on underlying cause of death alone. Our results may be used to inform public health resource allocation for infectious disease prevention and treatment programs, provide novel insight into the current state of infectious disease mortality throughout the state, and benefited from approaches that may more accurately document mortality trends.

Show MeSH
Related in: MedlinePlus