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Biomimetic strategies for sensing biological species.

Hussain M, Wackerlig J, Lieberzeit PA - Biosensors (Basel) (2013)

Bottom Line: A different strategy comprises of devising polymer coatings to change the biocompatibility of surfaces that can also be used to immobilized natural receptors/ligands and thus stabilize them.Rationally speaking, this leads to self-assembled monolayers closely resembling cell membranes, sometimes also including bioreceptors.It mainly focuses on the literature published since 2005.

View Article: PubMed Central - PubMed

Affiliation: Department of Analytical Chemistry, University of Vienna, Waehringer Strasse 38, A-1090, Vienna, Austria; E-Mails: munawar_arif@hotmail.com (M.H.); judith.maehner@univie.ac.at (J.W.).

ABSTRACT
The starting point of modern biosensing was the application of actual biological species for recognition. Increasing understanding of the principles underlying such recognition (and biofunctionality in general), however, has triggered a dynamic field in chemistry and materials sciences that aims at joining the best of two worlds by combining concepts derived from nature with the processability of manmade materials, e.g., sensitivity and ruggedness. This review covers different biomimetic strategies leading to highly selective (bio)chemical sensors: the first section covers molecularly imprinted polymers (MIP) that attempt to generate a fully artificial, macromolecular mold of a species in order to detect it selectively. A different strategy comprises of devising polymer coatings to change the biocompatibility of surfaces that can also be used to immobilized natural receptors/ligands and thus stabilize them. Rationally speaking, this leads to self-assembled monolayers closely resembling cell membranes, sometimes also including bioreceptors. Finally, this review will highlight some approaches to generate artificial analogs of natural recognition materials and biomimetic approaches in nanotechnology. It mainly focuses on the literature published since 2005.

No MeSH data available.


Different way opted for comparative studies in double imprinting. Reprinted with permission from [15], © 2012 American Chemical Society.
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biosensors-03-00089-f002: Different way opted for comparative studies in double imprinting. Reprinted with permission from [15], © 2012 American Chemical Society.

Mentions: Double imprinting approaches can also be applied to literally generate “plastic antibodies” that are inherently robust and selective. For instance, Schirhagl et al. [15] developed MIP layers to detect insulin. Additionally, they compared the binding properties of natural anti-insulin antibodies with the insulin surface MIP and achieved similar selectivity between insulin and glargin, but strongly increased sensitivity on the double MIP. Figure 2 depicts the different way opted for during these comparative studies.


Biomimetic strategies for sensing biological species.

Hussain M, Wackerlig J, Lieberzeit PA - Biosensors (Basel) (2013)

Different way opted for comparative studies in double imprinting. Reprinted with permission from [15], © 2012 American Chemical Society.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4263596&req=5

biosensors-03-00089-f002: Different way opted for comparative studies in double imprinting. Reprinted with permission from [15], © 2012 American Chemical Society.
Mentions: Double imprinting approaches can also be applied to literally generate “plastic antibodies” that are inherently robust and selective. For instance, Schirhagl et al. [15] developed MIP layers to detect insulin. Additionally, they compared the binding properties of natural anti-insulin antibodies with the insulin surface MIP and achieved similar selectivity between insulin and glargin, but strongly increased sensitivity on the double MIP. Figure 2 depicts the different way opted for during these comparative studies.

Bottom Line: A different strategy comprises of devising polymer coatings to change the biocompatibility of surfaces that can also be used to immobilized natural receptors/ligands and thus stabilize them.Rationally speaking, this leads to self-assembled monolayers closely resembling cell membranes, sometimes also including bioreceptors.It mainly focuses on the literature published since 2005.

View Article: PubMed Central - PubMed

Affiliation: Department of Analytical Chemistry, University of Vienna, Waehringer Strasse 38, A-1090, Vienna, Austria; E-Mails: munawar_arif@hotmail.com (M.H.); judith.maehner@univie.ac.at (J.W.).

ABSTRACT
The starting point of modern biosensing was the application of actual biological species for recognition. Increasing understanding of the principles underlying such recognition (and biofunctionality in general), however, has triggered a dynamic field in chemistry and materials sciences that aims at joining the best of two worlds by combining concepts derived from nature with the processability of manmade materials, e.g., sensitivity and ruggedness. This review covers different biomimetic strategies leading to highly selective (bio)chemical sensors: the first section covers molecularly imprinted polymers (MIP) that attempt to generate a fully artificial, macromolecular mold of a species in order to detect it selectively. A different strategy comprises of devising polymer coatings to change the biocompatibility of surfaces that can also be used to immobilized natural receptors/ligands and thus stabilize them. Rationally speaking, this leads to self-assembled monolayers closely resembling cell membranes, sometimes also including bioreceptors. Finally, this review will highlight some approaches to generate artificial analogs of natural recognition materials and biomimetic approaches in nanotechnology. It mainly focuses on the literature published since 2005.

No MeSH data available.