Limits...
Recent advances in fluorescent arylboronic acids for glucose sensing.

Hansen JS, Christensen JB - Biosensors (Basel) (2013)

Bottom Line: The long-term consequences of high blood glucose levels include damage to the heart, eyes, kidneys, nerves and other organs, among others, caused by malign glycation of vital protein structures.Fluorescent monitors based on arylboronic acids are promising candidates for optical CGM, since arylboronic acids are capable of forming arylboronate esters with 1,2-cis-diols or 1,3-diols fast and reversibly, even in aqueous solution.The recent progress in the development of fluorescent arylboronic acid dyes will be emphasized in this review.

View Article: PubMed Central - PubMed

Affiliation: Department of Chemistry, University of Copenhagen, Thorvaldsensvej 40, DK-1871 Frederiksberg C, Copenhagen, Denmark. jonhansen@chem.ku.dk.

ABSTRACT
Continuous glucose monitoring (CGM) is crucial in order to avoid complications caused by change in blood glucose for patients suffering from diabetes mellitus. The long-term consequences of high blood glucose levels include damage to the heart, eyes, kidneys, nerves and other organs, among others, caused by malign glycation of vital protein structures. Fluorescent monitors based on arylboronic acids are promising candidates for optical CGM, since arylboronic acids are capable of forming arylboronate esters with 1,2-cis-diols or 1,3-diols fast and reversibly, even in aqueous solution. These properties enable arylboronic acid dyes to provide immediate information of glucose concentrations. Thus, the replacement of the commonly applied semi-invasive and non-invasive techniques relying on glucose binding proteins, such as concanavalin A, or enzymes, such as glucose oxidase, glucose dehydrogenase and hexokinases/glucokinases, might be possible. The recent progress in the development of fluorescent arylboronic acid dyes will be emphasized in this review.

No MeSH data available.


Related in: MedlinePlus

Modulation of the fluorescence upon binding of glucose to SWCNT-coated with 4-chlorophenylboronic acid (Reprinted with permission from [64]. Copyright 2012 American Chemical Society).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4263566&req=5

biosensors-03-00400-f007: Modulation of the fluorescence upon binding of glucose to SWCNT-coated with 4-chlorophenylboronic acid (Reprinted with permission from [64]. Copyright 2012 American Chemical Society).

Mentions: Immobilization of the sensing system offers many advantages for integration into a device, and this has been the topic for a number of research groups. Strano et al. [64,65] described a system consisting of aromatic boronic acids, which form stable complexes with single-walled carbon nanotubes (SWCNTs). The SWCNTs were solubilized in micelles in water by the surfactant, sodium cholate. SWCNTs are fluorescent in the near-infrared area, but upon binding of aromatic boronic acids, the fluorescence is quenched, and reappears upon the binding of carbohydrates, as shown in Figure 6. The altered emission spectra are depicted in Figure 7. The effect of fluorescence change was, however, dependent upon the structure of the boronic acid, and ensembles of 30 boronic acids in total were screened.


Recent advances in fluorescent arylboronic acids for glucose sensing.

Hansen JS, Christensen JB - Biosensors (Basel) (2013)

Modulation of the fluorescence upon binding of glucose to SWCNT-coated with 4-chlorophenylboronic acid (Reprinted with permission from [64]. Copyright 2012 American Chemical Society).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4263566&req=5

biosensors-03-00400-f007: Modulation of the fluorescence upon binding of glucose to SWCNT-coated with 4-chlorophenylboronic acid (Reprinted with permission from [64]. Copyright 2012 American Chemical Society).
Mentions: Immobilization of the sensing system offers many advantages for integration into a device, and this has been the topic for a number of research groups. Strano et al. [64,65] described a system consisting of aromatic boronic acids, which form stable complexes with single-walled carbon nanotubes (SWCNTs). The SWCNTs were solubilized in micelles in water by the surfactant, sodium cholate. SWCNTs are fluorescent in the near-infrared area, but upon binding of aromatic boronic acids, the fluorescence is quenched, and reappears upon the binding of carbohydrates, as shown in Figure 6. The altered emission spectra are depicted in Figure 7. The effect of fluorescence change was, however, dependent upon the structure of the boronic acid, and ensembles of 30 boronic acids in total were screened.

Bottom Line: The long-term consequences of high blood glucose levels include damage to the heart, eyes, kidneys, nerves and other organs, among others, caused by malign glycation of vital protein structures.Fluorescent monitors based on arylboronic acids are promising candidates for optical CGM, since arylboronic acids are capable of forming arylboronate esters with 1,2-cis-diols or 1,3-diols fast and reversibly, even in aqueous solution.The recent progress in the development of fluorescent arylboronic acid dyes will be emphasized in this review.

View Article: PubMed Central - PubMed

Affiliation: Department of Chemistry, University of Copenhagen, Thorvaldsensvej 40, DK-1871 Frederiksberg C, Copenhagen, Denmark. jonhansen@chem.ku.dk.

ABSTRACT
Continuous glucose monitoring (CGM) is crucial in order to avoid complications caused by change in blood glucose for patients suffering from diabetes mellitus. The long-term consequences of high blood glucose levels include damage to the heart, eyes, kidneys, nerves and other organs, among others, caused by malign glycation of vital protein structures. Fluorescent monitors based on arylboronic acids are promising candidates for optical CGM, since arylboronic acids are capable of forming arylboronate esters with 1,2-cis-diols or 1,3-diols fast and reversibly, even in aqueous solution. These properties enable arylboronic acid dyes to provide immediate information of glucose concentrations. Thus, the replacement of the commonly applied semi-invasive and non-invasive techniques relying on glucose binding proteins, such as concanavalin A, or enzymes, such as glucose oxidase, glucose dehydrogenase and hexokinases/glucokinases, might be possible. The recent progress in the development of fluorescent arylboronic acid dyes will be emphasized in this review.

No MeSH data available.


Related in: MedlinePlus