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Disentangling in vivo the effects of iron content and atrophy on the ageing human brain.

Lorio S, Lutti A, Kherif F, Ruef A, Dukart J, Chowdhury R, Frackowiak RS, Ashburner J, Helms G, Weiskopf N, Draganski B - Neuroimage (2014)

Bottom Line: Evidence from magnetic resonance imaging (MRI) studies shows that healthy aging is associated with profound changes in cortical and subcortical brain structures.The reliable delineation of cortex and basal ganglia using automated computational anatomy methods based on T1-weighted images remains challenging, which results in controversies in the literature.We interpret our findings as direct evidence for the impact of ageing-related brain tissue property changes on automated tissue classification of brain structures using SPM12.

View Article: PubMed Central - PubMed

Affiliation: LREN, Dept. of Clinical Neurosciences, CHUV, University of Lausanne, Lausanne Switzerland.

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Related in: MedlinePlus

T-values of regressors correlating the GM volume estimated from MT maps with age. Statistical map of a t-test at statistical threshold of pFWE < 0.05 displayed on MT image in standard MNI space.
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f0030: T-values of regressors correlating the GM volume estimated from MT maps with age. Statistical map of a t-test at statistical threshold of pFWE < 0.05 displayed on MT image in standard MNI space.

Mentions: The statistically significant results of this linear model were a negative correlation between age and MT derived GM volume maps in the whole putamen and the lateral part of the pallidum (see Fig. 6). The same linear model applied to R1 derived GM volume maps showed a negative correlation with age only in the anterior part of putamen and pallidum (see Fig. 7). We observed a significant negative correlation between age and regions where a greater GM volume was estimated with R1 than MT data.


Disentangling in vivo the effects of iron content and atrophy on the ageing human brain.

Lorio S, Lutti A, Kherif F, Ruef A, Dukart J, Chowdhury R, Frackowiak RS, Ashburner J, Helms G, Weiskopf N, Draganski B - Neuroimage (2014)

T-values of regressors correlating the GM volume estimated from MT maps with age. Statistical map of a t-test at statistical threshold of pFWE < 0.05 displayed on MT image in standard MNI space.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4263529&req=5

f0030: T-values of regressors correlating the GM volume estimated from MT maps with age. Statistical map of a t-test at statistical threshold of pFWE < 0.05 displayed on MT image in standard MNI space.
Mentions: The statistically significant results of this linear model were a negative correlation between age and MT derived GM volume maps in the whole putamen and the lateral part of the pallidum (see Fig. 6). The same linear model applied to R1 derived GM volume maps showed a negative correlation with age only in the anterior part of putamen and pallidum (see Fig. 7). We observed a significant negative correlation between age and regions where a greater GM volume was estimated with R1 than MT data.

Bottom Line: Evidence from magnetic resonance imaging (MRI) studies shows that healthy aging is associated with profound changes in cortical and subcortical brain structures.The reliable delineation of cortex and basal ganglia using automated computational anatomy methods based on T1-weighted images remains challenging, which results in controversies in the literature.We interpret our findings as direct evidence for the impact of ageing-related brain tissue property changes on automated tissue classification of brain structures using SPM12.

View Article: PubMed Central - PubMed

Affiliation: LREN, Dept. of Clinical Neurosciences, CHUV, University of Lausanne, Lausanne Switzerland.

Show MeSH
Related in: MedlinePlus