Disentangling in vivo the effects of iron content and atrophy on the ageing human brain.
Bottom Line: Evidence from magnetic resonance imaging (MRI) studies shows that healthy aging is associated with profound changes in cortical and subcortical brain structures.The reliable delineation of cortex and basal ganglia using automated computational anatomy methods based on T1-weighted images remains challenging, which results in controversies in the literature.Computational anatomy studies of ageing and neurodegeneration should acknowledge these effects, particularly when inferring about underlying pathophysiology from regional cortex and basal ganglia volume changes.
Affiliation: LREN, Dept. of Clinical Neurosciences, CHUV, University of Lausanne, Lausanne Switzerland.Show MeSH
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Mentions: The statistically significant results of this linear model were a negative correlation between age and MT derived GM volume maps in the whole putamen and the lateral part of the pallidum (see Fig. 6). The same linear model applied to R1 derived GM volume maps showed a negative correlation with age only in the anterior part of putamen and pallidum (see Fig. 7). We observed a significant negative correlation between age and regions where a greater GM volume was estimated with R1 than MT data.
Affiliation: LREN, Dept. of Clinical Neurosciences, CHUV, University of Lausanne, Lausanne Switzerland.