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Disentangling in vivo the effects of iron content and atrophy on the ageing human brain.

Lorio S, Lutti A, Kherif F, Ruef A, Dukart J, Chowdhury R, Frackowiak RS, Ashburner J, Helms G, Weiskopf N, Draganski B - Neuroimage (2014)

Bottom Line: Evidence from magnetic resonance imaging (MRI) studies shows that healthy aging is associated with profound changes in cortical and subcortical brain structures.The reliable delineation of cortex and basal ganglia using automated computational anatomy methods based on T1-weighted images remains challenging, which results in controversies in the literature.We interpret our findings as direct evidence for the impact of ageing-related brain tissue property changes on automated tissue classification of brain structures using SPM12.

View Article: PubMed Central - PubMed

Affiliation: LREN, Dept. of Clinical Neurosciences, CHUV, University of Lausanne, Lausanne Switzerland.

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Related in: MedlinePlus

T-values of voxel-based regressors correlating higher GM volume estimation from MT maps compared to R1 maps with the interaction between R2* values and age. Statistical map of a t-test at statistical threshold of pFWE < 0.05 displayed on MT image in standard MNI space.
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f0025: T-values of voxel-based regressors correlating higher GM volume estimation from MT maps compared to R1 maps with the interaction between R2* values and age. Statistical map of a t-test at statistical threshold of pFWE < 0.05 displayed on MT image in standard MNI space.

Mentions: The linear regressors weighting the simultaneous contribution of age and R2* showed that GM volume differences in the head of caudate and in the ventral part of putamen were positively correlated with age and R2*, as shown by Fig. 5. The substantia nigra and the cerebellar dentate were negatively correlated with these two parameters, as reported in Table 4. There was no significant interaction between the regressor and the gender of study participants. The mean Pearson coefficient for the correlation between the age regressor and PD* was not significant (p = 0.07).


Disentangling in vivo the effects of iron content and atrophy on the ageing human brain.

Lorio S, Lutti A, Kherif F, Ruef A, Dukart J, Chowdhury R, Frackowiak RS, Ashburner J, Helms G, Weiskopf N, Draganski B - Neuroimage (2014)

T-values of voxel-based regressors correlating higher GM volume estimation from MT maps compared to R1 maps with the interaction between R2* values and age. Statistical map of a t-test at statistical threshold of pFWE < 0.05 displayed on MT image in standard MNI space.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4263529&req=5

f0025: T-values of voxel-based regressors correlating higher GM volume estimation from MT maps compared to R1 maps with the interaction between R2* values and age. Statistical map of a t-test at statistical threshold of pFWE < 0.05 displayed on MT image in standard MNI space.
Mentions: The linear regressors weighting the simultaneous contribution of age and R2* showed that GM volume differences in the head of caudate and in the ventral part of putamen were positively correlated with age and R2*, as shown by Fig. 5. The substantia nigra and the cerebellar dentate were negatively correlated with these two parameters, as reported in Table 4. There was no significant interaction between the regressor and the gender of study participants. The mean Pearson coefficient for the correlation between the age regressor and PD* was not significant (p = 0.07).

Bottom Line: Evidence from magnetic resonance imaging (MRI) studies shows that healthy aging is associated with profound changes in cortical and subcortical brain structures.The reliable delineation of cortex and basal ganglia using automated computational anatomy methods based on T1-weighted images remains challenging, which results in controversies in the literature.We interpret our findings as direct evidence for the impact of ageing-related brain tissue property changes on automated tissue classification of brain structures using SPM12.

View Article: PubMed Central - PubMed

Affiliation: LREN, Dept. of Clinical Neurosciences, CHUV, University of Lausanne, Lausanne Switzerland.

Show MeSH
Related in: MedlinePlus