Disentangling in vivo the effects of iron content and atrophy on the ageing human brain.
Bottom Line: Evidence from magnetic resonance imaging (MRI) studies shows that healthy aging is associated with profound changes in cortical and subcortical brain structures.The reliable delineation of cortex and basal ganglia using automated computational anatomy methods based on T1-weighted images remains challenging, which results in controversies in the literature.Computational anatomy studies of ageing and neurodegeneration should acknowledge these effects, particularly when inferring about underlying pathophysiology from regional cortex and basal ganglia volume changes.
Affiliation: LREN, Dept. of Clinical Neurosciences, CHUV, University of Lausanne, Lausanne Switzerland.Show MeSH
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Mentions: The linear regressors weighting the simultaneous contribution of age and R2* showed that GM volume differences in the head of caudate and in the ventral part of putamen were positively correlated with age and R2*, as shown by Fig. 5. The substantia nigra and the cerebellar dentate were negatively correlated with these two parameters, as reported in Table 4. There was no significant interaction between the regressor and the gender of study participants. The mean Pearson coefficient for the correlation between the age regressor and PD* was not significant (p = 0.07).
Affiliation: LREN, Dept. of Clinical Neurosciences, CHUV, University of Lausanne, Lausanne Switzerland.