Limits...
Disentangling in vivo the effects of iron content and atrophy on the ageing human brain.

Lorio S, Lutti A, Kherif F, Ruef A, Dukart J, Chowdhury R, Frackowiak RS, Ashburner J, Helms G, Weiskopf N, Draganski B - Neuroimage (2014)

Bottom Line: Evidence from magnetic resonance imaging (MRI) studies shows that healthy aging is associated with profound changes in cortical and subcortical brain structures.The reliable delineation of cortex and basal ganglia using automated computational anatomy methods based on T1-weighted images remains challenging, which results in controversies in the literature.We interpret our findings as direct evidence for the impact of ageing-related brain tissue property changes on automated tissue classification of brain structures using SPM12.

View Article: PubMed Central - PubMed

Affiliation: LREN, Dept. of Clinical Neurosciences, CHUV, University of Lausanne, Lausanne Switzerland.

Show MeSH

Related in: MedlinePlus

T-values of voxel-based regressors correlating higher GM volume estimation from MT maps compared to R1 maps with R2* values. Statistical map of a t-test at statistical threshold of pFWE < 0.05 displayed on MT image in standard MNI space.
© Copyright Policy
Related In: Results  -  Collection


getmorefigures.php?uid=PMC4263529&req=5

f0015: T-values of voxel-based regressors correlating higher GM volume estimation from MT maps compared to R1 maps with R2* values. Statistical map of a t-test at statistical threshold of pFWE < 0.05 displayed on MT image in standard MNI space.

Mentions: The GM volume differences between MT and R1 based GM volume estimations correlated positively with R2* maps in caudate, ventral part of putamen and pallidum, substantia nigra, lateral geniculate body of thalamus, cingulate, prefrontal cortex and dentate as reported in Table 2 (Fig. 3). The body of the caudate correlated positively with R2*, age and with the combined contribution of the two (see Figs. 3, 4, 5). Within our cohort the computed mean Pearson correlation coefficient between R2* and PD* was − 0.65 (p < 0.05).


Disentangling in vivo the effects of iron content and atrophy on the ageing human brain.

Lorio S, Lutti A, Kherif F, Ruef A, Dukart J, Chowdhury R, Frackowiak RS, Ashburner J, Helms G, Weiskopf N, Draganski B - Neuroimage (2014)

T-values of voxel-based regressors correlating higher GM volume estimation from MT maps compared to R1 maps with R2* values. Statistical map of a t-test at statistical threshold of pFWE < 0.05 displayed on MT image in standard MNI space.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4263529&req=5

f0015: T-values of voxel-based regressors correlating higher GM volume estimation from MT maps compared to R1 maps with R2* values. Statistical map of a t-test at statistical threshold of pFWE < 0.05 displayed on MT image in standard MNI space.
Mentions: The GM volume differences between MT and R1 based GM volume estimations correlated positively with R2* maps in caudate, ventral part of putamen and pallidum, substantia nigra, lateral geniculate body of thalamus, cingulate, prefrontal cortex and dentate as reported in Table 2 (Fig. 3). The body of the caudate correlated positively with R2*, age and with the combined contribution of the two (see Figs. 3, 4, 5). Within our cohort the computed mean Pearson correlation coefficient between R2* and PD* was − 0.65 (p < 0.05).

Bottom Line: Evidence from magnetic resonance imaging (MRI) studies shows that healthy aging is associated with profound changes in cortical and subcortical brain structures.The reliable delineation of cortex and basal ganglia using automated computational anatomy methods based on T1-weighted images remains challenging, which results in controversies in the literature.We interpret our findings as direct evidence for the impact of ageing-related brain tissue property changes on automated tissue classification of brain structures using SPM12.

View Article: PubMed Central - PubMed

Affiliation: LREN, Dept. of Clinical Neurosciences, CHUV, University of Lausanne, Lausanne Switzerland.

Show MeSH
Related in: MedlinePlus