Disentangling in vivo the effects of iron content and atrophy on the ageing human brain.
Bottom Line: Evidence from magnetic resonance imaging (MRI) studies shows that healthy aging is associated with profound changes in cortical and subcortical brain structures.The reliable delineation of cortex and basal ganglia using automated computational anatomy methods based on T1-weighted images remains challenging, which results in controversies in the literature.Computational anatomy studies of ageing and neurodegeneration should acknowledge these effects, particularly when inferring about underlying pathophysiology from regional cortex and basal ganglia volume changes.
Affiliation: LREN, Dept. of Clinical Neurosciences, CHUV, University of Lausanne, Lausanne Switzerland.Show MeSH
Related in: MedlinePlus
Mentions: On visual inspection substantia nigra, rostral pallidum, caudal putamen and thalamus showed higher contrast against the surrounding tissue on the MT maps compared to the R1 maps (see supplementary material Fig. 1). The very same regions showed higher GM estimates after automated tissue classification (see supplementary material Fig. 2).
Affiliation: LREN, Dept. of Clinical Neurosciences, CHUV, University of Lausanne, Lausanne Switzerland.